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  • 1
    Electronic Resource
    Electronic Resource
    Effects of nitric oxide synthesis inhibition on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in the rat brain (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 671-680 
    Details
    ISSN: 1435-1463
    Keywords: Nitric oxide (NO·) ; methamphetamine ; neurotoxicity ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined effects of nitric oxide (NO·) synthesis inhibition on methamphetamine (MA)-induced dopaminergic and serotonergic neurotoxicity. The toxic dose of MA (5 mg/kg, sc, X4) significantly decreased contents of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum (ST), and significantly decreased contents of serotonin (5-HT) in the ST, nucleus accumbens (NA) and medial frontal contex (MFC). Coadministration with a NO· synthase inhibitor, Nω-nitro-L-arginine methyl ester (LNAME) (30 mg/kg, ip, X2), reduced the MA-induced decreases in contents of DA, DOPAC and HVA in the ST, but not reduced the MA-induced decreases in contents of 5-HT in the ST, NA and MFC. These findings suggest that the MA-induced dopaminergic, but not serotonergic neurotoxicity, may be related to the neural process such as NO· formation caused by the activation of postsynaptic DA receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271227
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Constitutive expression of the neutral PR-5 (OLP, PR-5d) gene in roots and cultured cells of tobacco is mediated by ethylene-responsive cis-element AGCCGCC sequences (1998)
    Springer
    Plant cell reports 18 (1998), S. 173-179 
    Details
    ISSN: 1432-203X
    Keywords: Key words Callus ; ERF (EREBP) ; Osmotin-like protein ; Root ; Tobacco
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The constitutive accumulation of tobacco neutral PR-5 (osmotin-like protein; OLP, PR-5d) in roots and cultured cells was studied in transgenic tobacco plants harboring the OLP promoter::GUS gene. This construct showed strong β-glucuronidase expression in vascular tissues and cortex of roots as well as in cultured cells. Analysis using a mutated promoter showed that ethylene-responsive elements (AGCCGCC) were necessary for constitutive expression in roots and cultured cells. An electrophoretic mobility shift assay indicated that ERF3 (EREBP3), an ethylene-responsive-element-binding factor that was reported to be expressed in roots and in cultured cells as well as in ethephon-treated leaves, could bind to the AGCCGCC sequences of the OLP gene. These findings suggest that AGCCGCC sequences and ERFs mediate the constitutive expression of the OLP gene in roots and cultured cells of tobacco.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050552
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats (1996)
    Springer
    Psychopharmacology 123 (1996), S. 182-186 
    Details
    ISSN: 1432-2072
    Keywords: Anxiety ; Conditioned fear stress ; Freezing behavior ; Serotonin reuptake inhibitors ; Citalopram ; Fluvoxamine ; Milnacipran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1–10 mg/kg) and fluvoxamine (3–30 mg/kg). Acute treatment with the serotonin (5-HT)/noradrenaline (NA) mixed reuptake inhibitor milnacipran (3–30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246175
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    Paper (German National Licenses)
    Fulltext
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