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  • 1
    Electronic Resource
    Electronic Resource
    Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 224-226 
    Details
    ISSN: 1437-1596
    Keywords: Key words Population study ; HUMFES ; HUMVWA ; HUMF13A01 ; D1S80 ; Philippines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Allele frequency distributions at the short tandem repeat (STR) loci HUMVWA, HUMFES, HUMF13A01 and of the variable number of tandem repeat (VNTR) locus D1S80 were determined in a Filipino population from Metro Manila (103 individuals) by use of the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE). The exact test demonstrated that all four loci had no deviations from Hardy-Weinberg equilibrium (HWE) with the only reservation that the exact test p-value for F13A01 is weak. The discriminating power is 0.82 for D1S80, and the expected exclusion chance is 0.85 for F13A01, 0.83 for FES, and 0.93 for VWA. The observed heterozygosity rates are 0.63 for D1S80, 0.66 for F13A01, 0.67 for FES, and 0.80 for VWA. The exact test for independance between all loci gave a p-value of 0.0195. This is the first time that Filipino population data of DNA loci of forensic importance are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050157
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  • 2
    Electronic Resource
    Electronic Resource
    Novel variants in the promoter region of the CREB gene in schizophrenic patients (1999)
    Springer
    Journal of human genetics 44 (1999), S. 428-430 
    Details
    ISSN: 1435-232X
    Keywords: Key words cAMP-responsive element-binding protein ; Transcription factor ; Promoter ; Variant ; Schizophrenia ; Clinical characteristics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used by most dopamine and serotonin receptor subtypes. In addition, CREB stimulates the expression of a number of genes, alterations in the expression of which may be associated with schizophrenia. The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia. Eighty unrelated schizophrenics and 100 healthy controls were screened for genetic variants of the CREB gene by SSCP analysis, followed by direct sequencing of PCR products. Two novel variants (−933T?C and −413G?A) were found only in schizophrenics. A patient with the −933T?C variant had unusual clinical characteristics in addition to typical schizophrenic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050196
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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