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  • 1995-1999  (2)
  • Emissions  (1)
  • Fasciocutaneous flap
  • Tribulin
Materialart
Erscheinungszeitraum
Jahr
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Psychopharmacology 135 (1998), S. 361-367 
    ISSN: 1432-2072
    Schlagwort(e): Key words Streptozotocin ; Experimental diabetes mellitus ; Anxiety ; Diazepam ; Brain monoamines ; Tribulin ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The anxiolytic activity of diazepam (DZP) (0.25–1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various anxiety paradigms, including the open-field exploratory behaviour, elevated plus maze and elevated zero maze behaviours and the social interaction tests. In addition, rat brain tribulin activity was also assessed as a biochemical marker of anxiety. The results indicate that diabetic rats showed significantly more anxiogenic activity in comparison to non-diabetic rats on open-field, elevated plus maze, zero maze and social interaction tests. In diabetic rats, brain tribulin activity (MAO-A inhibitory component) was significantly increased. DZP dose dependently produced anxiolytic activity on the various behavioural parameters in non-diabetic rats. DZP (0.5 and 1 mg/kg) partially reversed the anxiogenic behaviour of STZ diabetic rats in elevated plus maze and zero maze tests. However, in open field behaviour and social interaction tests significant anxiolytic activity was observed only at a higher dose of DZP (1 mg/kg). The findings indicate that STZ-induced diabetic rats exhibited augmented anxiety on various experimental paradigms and that the anxiolytic effect of diazepam was less marked in diabetic rats as compared to their euglycaemic counterparts.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1573-2932
    Schlagwort(e): Asia ; Acid Rain ; Energy ; Emissions ; Sulfur Deposition ; Critical Loads ; Sulfur Dioxide ; Conservation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Notizen: Abstract In contrast to Europe and North America, air pollution in Asia is increasing rapidly, resulting in both local air quality problems and higher acidic depositions. In 1989, an east-west group of scientists initiated a multi-institutional research project on Acid Rain and Emissions Reduction in Asia, funded for the past two years by the World Bank and the Asian Development Bank. Phase I, covering 23 countries of Asia, focussed on the development of PC-based software called the Regional Air Pollution INformation and Simulation Model (RAINS-ASIA). A 94-region Regional Energy Scenario Generator was developed to create alternative energy/emission scenarios through the year 2020. A long-range atmospheric transport model was developed to calculate dispersion and deposition of sulfur, based upon emissions from area and large point sources, on a one-degree grid of Asia. The resulting impacts of acidic deposition on a variety of vegetation types were analyzed using the critical loads approach to test different emissions management strategies, including both energy conservation measures and sulfur abatement technologies.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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