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  • 1995-1999  (3)
  • Epilepsy  (1)
  • Ergonovine  (1)
  • Fractal analysis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Prolonged but not acute fluoxetine administration produces its inhibitory effect on hippocampal seizures in rats (1995)
    Springer
    Psychopharmacology 118 (1995), S. 305-309 
    Details
    ISSN: 1432-2072
    Keywords: Epilepsy ; Serotonin ; Fluoxetine ; Gepirone ; Long-term treatment ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study assessed the effects of acute as well as long-term administration of fluoxetine, a selective serotonin (5-HT) reuptake inhibitor with anti-depressant properties, on hippocampal (HIP) seizures elicited by electrical stimulation in rats. The fluoxetine effect on HIP seizures was also assessed following long-term treatment with gepirone, a 5-HT1A receptor agonist. Acute single administration of fluoxetine (1, 10 mg/kg; IP) was found to produce no significant effect on HIP seizure activity. Following daily IP administration of fluoxetine (10 mg/kg per day) or gepirone (10 mg/kg per day) for 21 days, animals were given a 7-day drug-free period and then challenged with an acute dose of 10 mg/kg fluoxetine. These treatment regimens resulted in a significantly increased afterdischarge threshold of HIP seizures in response to acute fluoxetine administration. The inhibitory effect of fluoxetine, however, was not present 4 weeks after long-term treatment with either fluoxetine or gepirone. The present results indicate that long-term treatment with these compounds enhances the antiepileptic effect of subsequent fluoxetine administration on the generation of HIP seizures. This effect is possibly related to the well-demonstrated evidence that fluoxetine and gepirone, on long-term treatment, facilitate net 5-HT neurotransmission through desensitization of presynaptic 5-HT autoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245959
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multiresolutional image analysis of wood and other materials (1999)
    Springer
    Journal of wood science 45 (1999), S. 10-18 
    Details
    ISSN: 1611-4663
    Keywords: Multiresolutional contrast ; Fractal analysis ; Gloss of wood ; Texture analysis ; Digital image analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The gloss of wood is a unique texture compared to that of other materials. To express it quantitatively, two digital-image analyses were performed. One method was multiresolutional contrast analysis, which was the new method developed in this study. The other method was fractal image analysis. Twenty-four specimens, including solid woods, wood-plastic composites (WPCs), printed grains, and granites, were prepared. Digital images of specimens were obtained in five sizes and in two illuminant directions (perpendicular and parallel to the grain). The multiresolutional contrast values of perpendicular illuminated images were calculated and compared among specimens. The result of this quantitative analysis was that the gloss of wood was characterized by bright spots in a relatively small area. Using fractal analysis, the fractal dimension of a digital image was used as an index of brightness changes, not for expressing the self-similarity. These indices showed results similar to those of the multiresolutional contrast analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579518
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mechanisms of ergonovine-induced hyperconstriction of coronary artery after x-ray irradiation in pigs (1995)
    Springer
    Basic research in cardiology 90 (1995), S. 167-175 
    Details
    ISSN: 1435-1803
    Keywords: Ergonovine ; coronary hyperconstriction ; serotonin2 receptor ; endothelium-dependent relaxation ; x-ray irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mechanisms of ergonovine-induced coronary hyperconstriction were examined in vivo and in vitro in miniature pigs. To provoke coronary hyperconstriction, the endothelium of a segment of a major branch of the left coronary artery was denuded in 19 Göttingen miniature pigs (4 to 6 months of age). In Group I (n=12), the denuded site of the coronary artery was selectively irradiated with 15 Gy of x-ray twice, 3 and 4 months after endothelial denudation. The remaining 7 pigs were not irradiated (Group II). The vasoconstrictive effect of intracoronary administration of ergonivine (1 to 1000 μg) was examined angiographically 3 months (just before irradiation in group I) and 5 months after denudation in the two groups. After the angiographical study, the vessels were isolated and isometric tensions were measured in an organ chamber. In the in vivo studies, ergonovineinduced vasoconstriction at the denuded and x-ray irradiated site in Group I was significantly greater than that at the control site or that at the denuded site in Group II. Pretreatments with serotonin receptor blockers (ketanserin or methysergide) significantly attenuated ergonovine-induced hyperconstriction, while an alpha-adrenergic receptor blocker (prazosin) did not (% inhibition; ketanserin 74±9%, p〈0.01, methysergide 60±10%, p〈0.01, prazosin 9±5%, NS). In the in vitro studies, ergonivine produced significantly greater tension at the denuded and x-ray irradiated site (Group I) than at the control site or at the denuded site (Group II). Ergonovine-induced endotheliumdependent relaxation was impaired at the denuded site in both groups to a similar extent. These results suggest that ergonovine-induced hyperconstriction at the denuded and x-ray irradiated coronary artery resulted mainly from the hyperreactivity of medial smooth muscle mediated by serotonin2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789446
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    Paper (German National Licenses)
    Fulltext
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