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  • 1995-1999  (3)
  • Five-year survival rate.  (1)
  • Homologous recombination  (1)
  • Lymph node dissection  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Die Operationsmethodik bestimmt die Rezidivhäufigkeit colorectaler Carcinome Ein Vergleich der Ergebnisse von 2 chirurgischen Kliniken (1999)
    Springer
    Der Chirurg 70 (1999), S. 1042-1049 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Colorectal carcinoma ; Operative technique ; Recurrence rate ; Five-year survival rate. ; Schlüsselwörter: Colorectale Carcinome ; Operationsmethodik ; Rezidivrate ; 5-Jahres-Überlebensrate.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Einleitung: Um zu prüfen, ob die Operationsmethodik die 5-Jahres-Rezidivrate und -Überlebensrate bestimmt, haben wir die Ergebnisse von 2 chirurgischen Kliniken mit unterschiedlicher Operationsmethodik (Klinik A: Entfernung des Tumors und der tumornahen Lymphknoten, Klinik B: En bloc-Resektion nach den Regeln der standardisierten Tumorchirurgie) analysiert. Patienten und Methoden: Analyse der Operationsergebnisse aller zwischen 1984–1988 operierten Patienten mit colorectalem Carcinom (Klinik A: 152 Colon- und 53 Rectumcarcinome; Klinik B: 124 Colon- bzw. 177 Rectumcarcinome). Ergebnisse: Die Lokalrezidivraten bei Klinik A signifikant höher (Coloncarcinome Klinik A 25 %, Klinik B 10 %; Rectumcarcinome Klinik A 54 %, Klinik B 16 %. Die 5-Jahres-Überlebensrate betrug bei den Coloncarcinomen in Klinik A 65 %, in Klinik B 66 %, bei den Rectumcarcinomen in Klinik A 49 %, in Klinik B 72 %. Schlußfolgerungen: Aus dieser Analyse läßt sich ableiten, daß ein colorectales Carcinom nur dort operiert werden sollte, wo die Standards der colorectalen Carcinomchirurgie eingehalten werden.
    Notes: Summary. Introduction: In order to investigate whether operative technique determines the 5-year recurrence and survival rates, we analysed the results obtained by two surgical departments using two different operative techniques. Department A: Removal of the tumour and a number of lymph nodes; department B: En-bloc resection in accordance with the requirements of standardised tumour surgery. Patients and methods: The surgical results obtained with all patients with colorectal carcinoma operated on between 1984 and 1988 (department A: 152 colon and 53 rectal carcinomas; department B: 124 colon and 177 rectal carcinomas). Results: The local recurrence rate achieved by department A was signicantly higher (colon carcinoma: department A 25 %; department B 10 %; rectal carcinoma: department A 54 %; department B 16 %). The 5-year survival rate for colon carcinoma was 65 % in department A, and 66 % in department B, the corresponding figures for rectal carcinoma being 49 % and 72 %, respectively. Conclusion: The results indicate that carcinoma of the colorectum should be operated on only at an institution that complies with the standards required for surgery of colorectal carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050765
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A specific member of the Cab multigene family can be efficiently targeted and disrupted in the moss Physcomitrella patens (1999)
    Springer
    Molecular genetics and genomics 261 (1999), S. 92-99 
    Details
    ISSN: 1617-4623
    Keywords: Key words Gene disruption ; Gene targeting ; Homologous recombination ; Plant transformation ; Physcomitrella patens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The analysis of phenotypic change resulting from gene disruption following homologous recombination provides a powerful technique for the study of gene function. This technique has so far been difficult to apply to plants because the frequency of gene disruption following transformation with constructs containing DNA homologous to genomic sequences is low (0.01 to 0.1%). It has recently been shown that high rates of gene disruption (up to 90%) can be achieved in the moss Physcomitrella patens using genomic sequences of unknown function. We have used this system to examine the specificity of gene disruption in Physcomitrella using a member of the Cab multigene family. We have employed the previously characterised Cab gene ZLAB1 and have isolated segments of 13 other closely related members of the Cab gene family. In the 199-bp stretch sequenced, the 13 new members of the Cab family show an average of 8.5% divergence from the DNA sequence of ZLAB1. We observed 304 silent substitutions and 16 substitutions that lead to a change in the amino acid sequence of the protein. We cloned 1029 bp of the coding region of ZLAB1 (including 177 of the 199 bp with high homology to the 13 new Cab genes) into a vector containing a selectable hygromycin resistance marker, and used this construct to transform P. patens. In three of nine stable transformants tested, the construct had inserted in, and disrupted, the ZLAB1 gene. There was no discernible phenotype associated with the disruption. We have therefore shown that gene disruption is reproducible in P. patens and that the requirement for sequence homology appears to be stringent, therefore allowing the role of individual members of a gene family to be analysed in land plants for the first time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050945
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphknotendissektionen beim malignen Melanom (1996)
    Springer
    Der Chirurg 67 (1996), S. 779-787 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Malignant melanoma ; Lymph node metastases ; Lymph node dissection ; Prognosis. ; Schlüsselwörter: Malignes Melanom ; Lymphknotenmetastasierung ; Lymphknotendissektion ; Prognose.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die Indikation zur elektiven Lymphknotendissektion, ihre evtl. zukünftige Bedeutung als Stagingmaßnahme vor adjuvanten Therapieverfahren, die Prognose der therapeutischen Dissektion sowie die Identifizierung des Pförtner-Lymphknotens und die daraus sich ergebenden therapeutischen Konsequenzen sind die wichtigsten Aspekte der Lymphknotendissektion beim malignen Melanom. Die Indikation zur elektiven Dissektion orientiert sich nicht nur an der pT-Kategorie, sondern auch an der Tumorlokalisation, dem Tumortyp und dem Geschlecht des Patienten. Ein allgemein akzeptierter Konsens zur Auswahl der in Frage kommenden Patienten besteht noch nicht. Da die ersten Studien mit Chemo-/Immuntherapie bei nodal positiven Patienten eine Prognoseverbesserung zeigen, muß zukünftig auch die Lymphknotendissektion als Stagingmaßnahme diskutiert werden. Neue Anregungen wurden in den letzten Jahren durch die Identifikation des Pförtner(„sentinel“)-Lymphknotens eingebracht. Diese Methodik bedarf noch der weiteren Evaluierung, dürfte aber zukünftig einen wesentlichen Einfluß auf die Indikation zur elektiven Lymphknotendissektion nehmen. Mit eingetretener Lymphknotenmetastasierung verschlechtert sich die Prognose des malignen Melanoms global um 20–50 %, abhängig vom Ausmaß der Metastasierung. Die Thematik wird anhand der eigenen Ergebnisse diskutiert.
    Notes: Summary. Elective lymph node dissection and its potential as a staging procedure, the prognosis of established lymph node metastases and the sentinel lymph node identification procedure are the most important aspects of lymph node dissection in malignant melanoma. It is widely accepted that subgroups of patients benefit from elective lymph node dissection. The question of which parameters identify the relevant patients properly is still under discussion. pT-categories are the most important prognostic factor; however, localisation and type of tumour and the sex of the patients are additional parameters influencing patient selection. Recently, the first studies have identified subgroups of nodal positive patients who would profit from adjuvant chemo-/immunotherapy. Therefore, lymph node dissection as a staging procedure has to be discussed in the future. Identification of the sentinel lymph node is receiving increasing attention because of its potential influence on the reassessment of elective lymph node dissection. However, this method needs further evaluation. If lymph node metastases have occurred, the prognosis of malignant melanoma decreases by 20 %–50 %, depending on the extent of metastasis in the individual case. The relevant topics and results are discussed on the basis of data of the Surgical Department of the University Hospital of Erlangen-Nuremberg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00002518
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    Paper (German National Licenses)
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