ISSN:
1435-1463
Keywords:
Dementia of the Alzheimer type (DAT)
;
postmortem human brain
;
adenylyl cyclase
;
Western blot
;
calcium
;
calmodulin
;
cAMP
;
signal transduction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Immunoreactivities of four subtypes of adenylyl cyclase (AC) (types I, II, IV and V/VI), and basal, forskolin- and Mn2+-stimulated AC activities with or without calcium and calmodulin (Ca2+/CaM) were estimated in parietal cortex membranes from cases with dementia of the Alzheimer type (DAT) and age-matched controls. Immunoreactivities of AC-I and AC-II were significantly decreased, but those of AC-IV and AC-V/VI did not change in DAT brains. There was a significant correlation of AC-I immunoreactivity with Ca2+/CaM-sensitive AC activity, but not with the Ca2+/CaM-insensitive activity. Ca2+/CaM-sensitive AC activity was significantly lower in DAT than in the control, indicating that impairment of Ca2+/CaM-sensitive AC-I is clearly involved in the pathophysiology of DAT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01291889
Permalink
