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  • 1995-1999  (2)
  • Histopathology  (1)
  • Man  (1)
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  • 1995-1999  (2)
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  • 1
    ISSN: 1432-2307
    Keywords: HCV ; Genotypes ; Histopathology ; Grading ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper describes the correlation of hepatitis C genotypes detected in liver tissue with histological grading (inflammatory activity) and staging (degree of fibrosis/cirrhosis). The viral genotype was analysed by type-specific polymerase chain reaction (PCR) and correlated with histology and age of patients. In 69 patients with chronic hepatitis C (HCV) infection, genotypes 1a and 1b were detected in 13 (18.8%) and 31 (44.9%) liver biopsies, respectively. Genotypes 2a and 2b were each detected once (1.5%) and 12 (17.4%) tissue samples showed a mixed infection with two genotypes. In 11 (15.9%) biopsies, no genotype could be established. The liver specimens were grouped according to the presence or absence of genotype 1b: group A consisted of specimens infected with genotypes 1a, 2a, and 2b (n=16), Group B contained biopsies infected with genotype 1b (n=42), and group C were biopsies with no detectable genotype (n=11). Activity (grade) of chronic hepatitis was not different in these three groups. However, advanced fibrosis/cirrhosis was observed in 16 (38.1%) biopsies in group B (containing genotype 1b), compared with none in group A (P=0.01). The mean age of patients in group B was significantly higher than that in group A (P=0.038), and the mean age of patients with advanced fibrosis was higher than that of patients with low fibrosis scores within these two groups (P=0.004). Stepwise logistic regression revealed an independent association of age and genotype 1b (group B) with advanced fibrosis/cirrhosis. These data indicate that patients infected with genotype 1b have an higher risk of developing cirrhosis than do patients with other genotypes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 436 (1998), S. 343-356 
    ISSN: 1432-2013
    Keywords: Key words Energetics ; Gait ; Kinematics ; Locomotion ; Man ; Mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Twenty-four subjects walked at different speeds (V) from 0.4 to 2.6 m s–1, while motion and ground reaction forces were recorded in 3-D space. The total mechanical energy of each body segment was computed as the sum of the gravitational potential, translation and rotation kinetic energies. Energy profiles reveal that there are inter-individual differences, particularly at moderate and fast V. In some subjects, the energy excursions are less pronounced, and tend to evolve out of phase at the lower limbs and trunk. As a consequence, there is a better transfer of energy between the trunk and the leg segments, resulting in smaller oscillations of the net energy of the whole body. There is a threefold variation of the rate of increment of lnP u (the mass-specific mean absolute power) with lnV across subjects. We show that this variability cannot be simply explained on the basis of the different biomechanical characteristics of the subjects, but that it depends on the different kinematic strategies. Subjects differ in their ability to minimize energy oscillations of their body segments and to transfer mechanical energy between the trunk and the limbs. Individual characteristics of the mechanical energy expenditure were correlated with the corresponding kinematic characteristics. The changes of the elevation angles of the lower limb segments covary along a plane in all subjects. Plane orientation (quantified by the direction cosine of the normal with the thigh axis, u 3t ) at any V is not the same in all subjects, but correlates with the net power output: smaller values of u 3t tend to be associated with smaller values of P u , and vice versa.
    Type of Medium: Electronic Resource
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