ISSN:
1432-1335
Keywords:
Key words P-Glycoprotein
;
Immunocytochemistry
;
Bleomycin
;
Drug resistance
;
Malignant effusions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase method. Samples were taken before and 3 and 7 days after intracavitary bleomycin therapy and reaccumulation of effusion was assessed at 30 days. Smears that were P-gp-negative by the 7th day were associated with a good 30-day response to bleomycin in the majority of cases, while P-gp-positive smears were associated with a significant reaccumulation of fluid at 30 days. P-gp status is a valuable prognostic indicator of response to intracavitary bleomycin treatment in effusions from breast or ovarian cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01372551
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