ISSN:
1432-0878
Keywords:
Key words LTBP
;
Isoforms
;
Splice variants
;
Extracellular matrix
;
TGFβ
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Latent transforming growth factor-β (TGFβ) binding protein (LTBP), a component of the high-molecular-weight latent TGFβ complex, is found in various cell and tissue types. Originally described as a TGFβ-masking protein, recent detections of four isoforms and numerous splice variants provide new aspects of its putative functional role. Regulation and sequestration of TGFβ activity and structural remodeling of the extracellular matrix (ECM) seem to be the main tasks, but other possible functions might exist. The mechanism by which LTBP interacts with cell surface molecules or cellular receptors and ECM components remains unclear. Cellular, molecular and functional aspects will be discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004410051364
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