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  • 1995-1999  (2)
  • Key words Acute myocardial infarction  (1)
  • Key words: Bone turnover — Glycemic control —Insulin-like growth factor I — Noninsulin-dependent diabetes mellitus — Osteocalcin — Pyridinium cross-links.  (1)
  • 1
    ISSN: 1432-0827
    Keywords: Key words: Bone turnover — Glycemic control —Insulin-like growth factor I — Noninsulin-dependent diabetes mellitus — Osteocalcin — Pyridinium cross-links.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. It is unclear whether both bone resorption and formation are affected by glycemic control, and contribute to diabetic osteopenia. In this study, 20 patients with noninsulin-dependent diabetes mellitus (12 men and 8 postmenopausal women) and 20 healthy control subjects (10 men and 10 postmenopausal women) were examined at baseline and 2 months. The diabetic patients showed an improvement of glycemic control (decreased HbA1c) at the second measurement. Analysis of variance showed that there was no effect of gender on the variables that increased with improved glycemic control, and therefore results are presented for both male and female subjects. Baseline values of serum osteocalcin, a marker of formation, were significantly lower in diabetic patients compared with healthy subjects (2.5 ± 1.3 versus 4.4 ± 1.4 ng/ml; P= 0.0006), but markers of bone resorption [urinary pyridinoline (PYD), deoxypyridinoline (DPD)] did not differ. Improved glycemic control in diabetic patients resulted in increased values of PYD (P= 0.012), DPD (P= 0.049), serum osteocalcin (P= 0.001), and serum insulin-like growth factor I (IGF-I, P= 0.003), but no change in serum parathyroid hormone or 25-hydroxyvitamin D. In diabetic patients there were inverse correlations for the percent change from baseline to improved glycemic control for osteocalcin and HbA1c (r =−0.53; P= 0.016) and glucose (r =−0.46; P= 0.050). These data suggest that improved glycemic control is accompanied by an increase in bone turnover for male and female diabetic patients, possibly mediated by increased levels of circulating IGF-I.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensivmedizin und Notfallmedizin 36 (1999), S. 722-726 
    ISSN: 1435-1420
    Keywords: Key words Acute myocardial infarction ; registry ; guidelines ; early therapy ; thrombolysis ; media campaign ; Schlüsselwörter Akuter Myokardinfarkt ; Register ; Richtlinien ; Akuttherapie ; Thrombolyse ; Bevölkerungsaufklärung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Ludwigshafener Herzinfarktprojekt hat gezeigt, daß durch eine intensive regionale Aufklärung der Bevölkerung die prähospitalen Zeitverluste beim Herzinfarkt verkürzt werden können. Mit einer zusätzlichen klinikinternen Optimierung können dadurch mehr Patienten eine rekanalisiernde Therapie (Lyse oder PTCA) erhalten, die Begleittherapie mit ASS, β-Blocker und ACE-Hemmer kann ebenfalls wesentlich häufiger eingesetzt werden. In mehreren großen multizentrischen Qualitätsregistern (60-Minuten-Herzinfarkt-Projekt, MIR und MITRA) bei insgesamt ca. 35000 konsekutiv erfaßten Patienten an mehreren Hundert Krankenhäusern in Deutschland konnte gezeigt werden, daß die klinikinterne Optimierung der Infarkttherapie sehr gut auf andere Kliniken übertragbar ist. Die freiwillige Teilnahme an einem Herzinfarktregister führt zur Qualitätskontrolle und zu einer erheblichen Verbesserung der Infarkttherapie. Zwei Maßnahmen tragen besonders hierzu bei: (1) die Dokumentation im Rahmen des Infarktregisters, und (2) die schriftliche Begründung, warum die jeweilige Therapie gegeben wurde oder nicht. Die Verbesserung der Akuttherapie geht mit einer Senkung der Infarktletalität um 20% einher (MITRA-1). Dagegen ließ sich die in Ludwigshafen durchgeführte intensive und aufwendige Bevölkerungsaufklärung bisher nicht genügend effektiv auf andere Regionen übertragen.
    Notes: Summary The Ludwigshafen myocardial infarction project demonstrated, that an intense public media campaign can reduce prehospital delay times in acute myocardial infarction. With the addition of an intrahospital improvement, this can lead to a better and more frequent use of recanalisation (thrombolysis or PTCA). Several large multicentric registries (60 minutes myocardial infarction project, MIR, MITRA) with a total of about 35,000 patients at over 300 hospitals in Germany showed, that the intrahospital improvement of infarction therapy can be achieved also in other hospitals. Voluntary participation in a infarction registry leads to quality control and improvement. Two factors are especially important. (1) documentation of every infarction patient and (2) documentation of the reasons why therapy was given or withheld in every single patient. The improvement in early therapy is associated with a 20% reduction of hospital mortality (MITRA-1). The media campaign in Ludwigshafen to reduce prehospital patient delay, however, could not be carried out in other areas effectively and intense enough so far.
    Type of Medium: Electronic Resource
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