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Digitale Medien

Role of syntaxin in mouse pancreatic beta cells (1995)

Martín, F. ; Moya, F. ; Gutierrez, L. M. ; [weitere]

Springer

Diabetologia 38 (1995), S. 860-863

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Details

ISSN: 1432-0428

Schlagwort(e): Key words Exocytosis ; syntaxin ; pancreatic beta cell ; secretion ; SNAP receptor.

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit Ca2+-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules. [Diabetologia (1995) 38: 860–863]

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s001250050364

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