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  • 1
    Electronic Resource
    Electronic Resource
    Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection (1996)
    Springer
    Inflammation research 45 (1996), S. 109-112 
    Details
    ISSN: 1420-908X
    Keywords: NG-nitro-L-arginine-methyl-ester (L-NAME) ; NG-monomethyl-L-arginine (L-NMMA) ; N-iminoethyl-L-ornithine (L-NIO) ; Septic shock ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model.Design: Prospective randomized experimental trials.Setting: Laboratory.Subjects: Female Balb/c mice.Interventions:Escherichia coli (108 colony-formingunits/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge.Measurements: One hundred and fifteen animals were observed for survival.Results: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time afterE. coli challenge.Conclusions: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265161
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Suppression of natural killer cell activity in mouse spleen lymphocytes by several dopamine receptor antagonists (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 343-348 
    Details
    ISSN: 1420-9071
    Keywords: Dopamine ; neuroleptics ; natural killer cell ; spleen lymphocytes ; interferon ; interleukin-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of dopaminergic receptor inhibitors such as thiothixine (D1/D2), fluphenazine (D1/D2), trifluoperazine (D1/D2), pimozide (D2), flupenthixol (D1/D2), (+/−)-SKF 83566 (D1), and spiperone (D2) on splenic natural killer (NK) cell cytotoxic activities were assessed in vitro using mouse spleen lymphocytes or enriched NK cells. Both the activities of the splenic NK cell cytotoxicity and the effector-target cell conjugation were suppressed by thiothixine, fluphenazine, and trifluoperazine at concentrations from 2.64 to 14.78 μM. In addition, the augmentation of the cytolytic activity of NK cells induced by interferon-α or interleukin-2 was antagonized by pretreatment with these neuroleptic compounds. However, neither the splenic NK cell cytotoxicity nor the effector-target cell conjugation were affected by treatment with other neuroleptic compounds such as pimozide, flupenthixol, (+/−)-SKF 83566, and spiperone. Thus, it appears that neuroleptic compounds such as thiothixine, fluphenazine, and trifluoperazine may act through the mechanisms other than a dopaminergic pathway to affect the NK cell-target cell interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928892
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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