ISSN:
1573-501X
Schlagwort(e):
Solid-phase organic synthesis
;
Resin impurities
;
Prewashing
;
Pretreatment
;
Parallel purification
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Summary A major objective of the DIVERSOMER® technology is to provide pure and characterized compounds for biological testing in order to prevent ‘false negatives’ in our libraries. On several occasions, analysis of the final products by1H-NMR and MS, has revealed by-products from the polystyrene solid support. Subsequently, three alternative methods were studied to remove polystyrene by-products; (i) prewashing of the resin prior to execution of the synthesis; (ii) pretreatment of the resin with the cleavage conditions consistent with the solid-phase synthesis reaction scheme; and (iii) parallel purification.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01544956
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