ISSN:
1432-2307
Keywords:
Cardiac muscle
;
Microvasculature
;
Septic shock
;
Porcine shock model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The morphology of cardiac muscle was investigated in a porcine model of septic shock, created by intermitted application of Escherichia coli-endotoxin. The earliest lesions, found after 18 h of septic shock, were endothelial cell swelling, marked leucostasis and slight ischaemic alterations of the muscle fibres. At the end point of the experiments, after 48 h, some fibrin thrombi were found associated with more pronounced ischaemic alterations of cardiac muscle cells and some necrotic fibres. Comparing these findings with the severe endothelial and muscle fibre lesions found in skeletal muscle, the endothelial cells of the heart microvasculature, are clearly more resistant to the attack of the endotoxins and mediators liberated in septic shock.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00193172
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