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  • 1
    Electronic Resource
    Electronic Resource
    Predicting length-of-stay in preterm neonates (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 59-62 
    Details
    ISSN: 1432-1076
    Keywords: Key words Artificial neural network ; Neural networks computer ; Length-of-stay ; Preterm neonate ; Prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a training-and-test (75%), or validation patient set (25%). A total of 40 first-day-of-life items (input data) and the date of discharge (output data) were routinely available. Training-and-test set data were used to identify input items with impact on LOS (input variables) using MR analysis to establish a MR prediction model and to train and test an ANN on those selected variables. Fed with validation set data, predicted LOS obtained from MR and ANN was compared individually with actual LOS. Predicted and actual LOS were highly correlated (for MR, r = 0.85 to 0.90; for ANN, r = 0.87 to 0.92). Conclusion Even first-day-of-life data may contain substantial information with which to predict individual length-of-stay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051010
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  • 2
    Electronic Resource
    Electronic Resource
    The “Pre-Molten Globule,” a New Intermediate in Protein Folding (1997)
    Springer
    The protein journal 16 (1997), S. 433-439 
    Details
    ISSN: 1573-4943
    Keywords: Pre-Molten globule ; folding intermediate ; NMR, proton exchange ; circular dichroism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In vitro folding studies of several proteins revealed the formation, within 2–4 msec, of transient intermediates with a large far-UV ellipticity but no amide proton protection. To solve the contradiction between the secondary structure contents estimated by these two methods, we characterized the isolated C-terminal fragment F2 of the tryptophan synthase β2 subunit. In β2, F2 forms its tertiary interactions with the F1 N-terminal region. Hence, in the absence of F1, isolated F2 should remain at an early folding stage with no long-range interactions. We shall show that isolated F2 folds into, and remains in, a “state” called the pre-molten globule, that indeed corresponds to a 2- to 4-msec intermediate. This condensed, but not compact, “state” corresponds to an array of conformations in rapid equilibrium comprising native as well as nonnative secondary structures. It fits the “new view” on the folding process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026397008011
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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