ISSN:
1432-5233
Keywords:
Key words GLP-1(7-36)amide
;
Glucose transport
;
Skeletal muscle
;
Rat
;
Extrapancreatic effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Glucagon-like peptide-1 binding sites have been reported in peripheral tissues including muscle. However, the potential extra-pancreatic effects of glucagon-like peptide-1(7-36)amide are controversial. To evaluate whether glucagon-like peptide-1(7-36)amide has any effects on skeletal muscle glucose transport, isolated rat soleus muscles were incubated in increasing concentrations of insulin (0–150 nmol/l) in the presence or absence of 1 nmol/l glucagon-like peptide-1(7-36)amide for 3 h. Subsequently glucose transport was measured as uptake of [3H]-O-methylglucose. It was found that glucagon-like peptide-(7-36)amide has a small but significant stimulating effect on skeletal muscle glucose transport independent of the insulin concentration (P〈0.01). However, because of the magnitude of the observed effect, the physiological importance of glucagon-like peptide-1 (7-36)amide on skeletal muscle glucose metabolism is questionable.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s005920050112
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