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Errors in Clearance Estimation After Bolus Injection and Arterial Sampling: Nonexistence of a Central Compartment (1997)

Weiss, Michael

Springer

Journal of pharmacokinetics and pharmacodynamics 25 (1997), S. 255-260

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ISSN: 1573-8744

Keywords: clearance estimation ; bolus injection ; arterial sampling ; initial mixing

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract In conventional pharmacokinetics monotonic decreasing drug disposition curves are usually assumed after bolus injection. For arterial sampling starting about 1 min after dosing the resulting neglect of the initial concentration peak leads to a relative overestimation of clearance which may be approximated by the percentage of systemic drug extraction. This error can be avoided by administering the drug as a short-term infusion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1025788214777

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