ISSN:
1573-8744
Keywords:
clearance estimation
;
bolus injection
;
arterial sampling
;
initial mixing
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In conventional pharmacokinetics monotonic decreasing drug disposition curves are usually assumed after bolus injection. For arterial sampling starting about 1 min after dosing the resulting neglect of the initial concentration peak leads to a relative overestimation of clearance which may be approximated by the percentage of systemic drug extraction. This error can be avoided by administering the drug as a short-term infusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1025788214777
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