ISSN:
1435-1463
Keywords:
[3H]clozapine
;
dopamine D4 receptor
;
frontal cortex
;
haloperidol
;
clozapine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We examined the effects of long-term treatment with haloperidol and clozapine on dopamine D4 receptors in rat frontal cortex. Dopamine D4 receptor binding sites were indirectly determined from the displacement experiments of [3H]clozapine binding using nemonapride. Three-weeks administration of haloperidol (0.5mg/kg) or clozapine (10mg/kg) did not significantly affect the D4 receptors in the frontal cortex. The density of D2 receptors, determined by [3H]spiperone binding to striatum, was increased by long-term treatment with haloperidol, but it was not significantly changed by that with clozapine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01271560
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