Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Activity of paclitaxel by three-hour infusion in Asian patients with metastatic undifferentiated nasopharyngeal cancer (1998)
    Springer
    Annals of oncology 9 (1998), S. 327-329 
    Details
    ISSN: 1569-8041
    Keywords: nasopharyngeal cancer ; paclitaxel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Despite its moderate anti-tumour activity in head and neck cancers there have been no reports on the activity of paclitaxel in patients with nasopharyngeal cancer, a highly chemosensitive tumour. A phase II study was thus initiated to determine the objective response rate and toxicity of paclitaxel in patients with previously untreated metastatic nasopharyngeal cancer. Patients and methods: Twenty-four patients with previously untreated measurable metastatic nasopharyngeal carcinoma were accrued, one of them ineligible because of concomitant beta-blocker usage. Male : female ratio was 19 : 5, with a median age of 46 years. All had previously received radiotherapy but were chemotherapy-naïve. The great majority (20 of 24) had undifferentiated carcinoma. Paclitaxel (Anzatax, Faulding Pharmaceuticals) 175 mg/m2 was given intravenously over three hours every 21 days after premedication with oral dexamethasone and intravenous diphenhydramine and cimetidine. Results: There were five (21.7%) partial responses while eight patients remained stable. Median response duration was 7.5 months and median survival was 12 months. The main toxicity was haematological, with grade 1–2 neutropenia in 19% and grade 3–4 neutropenia in 4.5% of cycles. Three cycles were complicated by grade 3–4 anaemia and one patient required a blood transfusion. No thrombocytopenia was seen. Peripheral neuropathy was frequent (20 of 23 patients) but mild. Alopecia was complete in 14 patients. There were no cardiac toxicity or hypersensitivity reactions. Conclusions: Paclitaxel is well tolerated even in previously irradiated patients with metastatic nasopharyngeal cancer. Single-agent activity was 22% and its inclusion into combination chemotherapy regimens should be studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008255220284
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Assembly Tolerance Stack Analysis for Geometric Characteristics in Form Control – the "Catena" Method (1999)
    Springer
    The international journal of advanced manufacturing technology 15 (1999), S. 292-298 
    Details
    ISSN: 1433-3015
    Keywords: Key words.Adjacent; Assembly tolerance stack analysis; "Catena" model; Flatness; Form control; Offset
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Tolerance stack analysis involving geometric characteristics is usually difficult as it involves numerous rules and conditions. Users need to acquire an adequate knowledge of geometric dimensioning and tolerancing before making any attempt at the computation of tolerance stack analysis problem. Conventional stack form methods are very widely used in tolerance stack analysis, but the computation requires tedious work with numerous rules to remember that often complicate the problem and confuse the user. A need therefore arises to simplify the tolerance stack methodology. This paper presents a straight forward, easy-to-use graphical approach known as the "Catena" method for tolerance stack analysis, involving geometric characteristics in form control – flatness, straightness, circu-larity and cylindricity. Three examples are given to illustrate the effectiveness of the proposed method. No complicated mathematical formulae are required in deriving the solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001700050069
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...