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  • 1995-1999  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Catecholamine-synthesizing enzymes in the rat stomach (1995)
    Springer
    Histochemistry and cell biology 104 (1995), S. 63-67 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. A rich innervation of TH- and DBH-immunoreactive nerve fibers was seen in the muscular layers and the myenteric plexus, in the submucosa and in the walls of submucosal blood vessels and in the lamina propria at the base of the epithelial layer. In addition, TH-, but not DBH-immunoreactive nerve fiber networks surrounding ganglion cells in the myenteric plexus were frequently observed, indicating dopaminergic preganglionic innervation of the myenteric plexus. In the oxyntic epithelium, single TH- and DBH-immunoreactive fibers extended in the strands of lamina propria as far as the middle portion of the gastric glands. A small population of single angulate cells in the oxyntic epithelium showed TH-, but not DBH-immunoreactivity. No specific PNMT immunoreactivity was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01464787
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of monensin on secretory granules and basal β-endorphin secretion in the melanotroph of the rat pituitary (1996)
    Springer
    Journal of molecular histology 28 (1996), S. 591-597 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of monensin on the Golgi complex, formation of secretory granules and basal β-endorphin secretion in cultured melanotrophs from the rat pituitary was studied. Earlier studies on the effect of monensin on regulated secretion have generally showed only minor effects on secretory granules. The initial (within 5 min) effect of monensin on the melanotroph was the appearance of large vacuoles at the trans-side of the thiamine pyrophosphatase-positive trans-most Golgi cisternae. This was associated with a dose-dependent inhibition of the condensation of electron-dense secretory products. After 1 h of treatment with 1 μM monensin the Golgi stack was completely vacuolized. At the same time mature secretory granules were enlarged to severalfold their original size, and after 4h of treatment secretory granules were no longer observed. Despite the marked effects on granule formation and mature secretory granules monensin did not affect the basal release of β-endorphin-immunoreactive material during continued incubation for up to 4h, indicating that basal peptide secretion can bypass the monensin block.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02331379
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 2250-2258 
    Details
    ISSN: 1573-2568
    Keywords: inflammatory bowel disease ; neuropeptide ; immunohistochemistry ; morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The amount of colonic substance P and substance P-receptors is increased in ulcerative colitis, which may denote that substance-P is involved as a neurogenic mediator in the inflammatory process of ulcerative colitis. We studied the anatomical distribution of elevated colonic substance P in ulcerative colitis and assessed morphometrically wheter the changes in substance P correlate with alterations in colonic innervation. Full-thickness specimens of colonic wall were obtained from normal human colons (N=9) and the most and least affected regions of ulcerative colitis colons (N=10) and immunostained for substance P. Substance P immunoreactivity index was calculated by multiplying each intensity value by the number of pixels exhibiting this intensity value. The numbers of substance P-immunoreactive nerve fibers in the lamina propria were markedly increased, and their fluorescence intensity was enhanced in ulcerative colitis. The longitudinal muscle layer contained substance P-immunoreactive nerve fibers in ulcerative colitis, but not in the controls. The substance P-immunoreactive index (=number×intensity of nerve fibers) was 3.42±1.49 in controls, 21.19±7.79 in mild ulcerative colitis regions (P〈0.05), and 29.68±9.81 in severe ulcerative colitis regions (P〈0.01). Increase in the number of substance P nerve fibers is in accordance with the hypothesis that substance P contributes to neurogenic mediation of inflammation in ulcerative colitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02209015
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    Paper (German National Licenses)
    Fulltext
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