ISSN:
1432-1459
Keywords:
Key words Bicycle ergometry
;
Coenzyme Q10
;
Lactate
;
Lactate/
;
pyruvate ratio
;
Mitochondrial
;
encephalomyopathies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We used a standardized bicycle ergometry protocol with a stepwise increasing workload (30–100 W) to evaluate various metabolic factors for the diagnosis and metabolic monitoring of mitochondrial encephalomyopathies. All patients (n = 9) showed pathological venous lactate/pyruvate (L/P) ratios, which normalized in three patients after 6 months of coenzyme Q10 (CoQ) therapy. Thus, the L/P ratio proved to be the clinically most useful parameter in the evaluation and monitoring of mitochondrial diseases, showing higher sensitivity than lactate measurements only. CoQ may exert a favourable effect in some patients with mitochondrial diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004150050267
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