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Preliminary X-ray analysis of a new crystal form of recombinant pig kidney DOPA decarboxylase (1999)

Malashkevich, V. N. ; Burkhard, P. ; Dominici, P. ; [et al.]

Copenhagen : International Union of Crystallography (IUCr)

Acta crystallographica 55 (1999), S. 568-570

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ISSN: 1399-0047

Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001

Topics: Chemistry and Pharmacology , Geosciences , Physics

Notes: DOPA decarboxylase is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. The crystals of recombinant DOPA decarboxylase differ from those previously reported for the enzyme purified from pig kidney. They belong to space group P622 with unit-cell dimensions a = b = 302.6, c = 178.1 Å. Both the self-rotation function and the good diffraction quality of these crystals (2.5 Å on a synchrotron source) suggest that there should be at least three protein dimers in the asymmetric unit. Diffraction data sets have been collected for the native enzyme and a heavy-atom derivative.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1107/S0907444998006283

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Plant-induced seizures: reappearance of an old problem (1999)

Burkhard, P. R. ; Burkhardt, Karim ; Haenggeli, Charles-Antoine ; [et al.]

Springer

Journal of neurology 246 (1999), S. 667-670

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ISSN: 1432-1459

Keywords: Key words Seizure ; Epilepsy ; Essential (plant ; vegetable ; volatile) ; oils ; Terpene

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Several plant-derived essential oils have been known for over a century to have epileptogenic properties. We report three healthy patients, two adults and one child, who suffered from an isolated generalized tonic-clonic seizure and a generalized tonic status, respectively, related to the absorption of several of these oils for therapeutic purposes. No other cause of epilepsy was found, and outcome was good in the two adult cases, but the course has been less favorable in the child. A survey of the literature shows essential oils of 11 plants to be powerful convulsants (eucalyptus, fennel, hyssop, pennyroyal, rosemary, sage, savin, tansy, thuja, turpentine, and wormwood) due to their content of highly reactive monoterpene ketones, such as camphor, pinocamphone, thujone, cineole, pulegone, sabinylacetate, and fenchone. Our three cases strongly support the concept of plant-related toxic seizure. Nowadays the wide use of these compounds in certain unconventional medicines makes this severe complication again possible.