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  • 1
    Electronic Resource
    Electronic Resource
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Keywords: Key words Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aβ). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated "stress-induced deposits" (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294806
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aß). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated “stress-induced deposits” (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294806
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of dotarizine on CO2-dependent cerebrovascular reactivity (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 186-188 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral blood flow ; hyperventilation ; calcium channel blocker ; dotarizine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dotarizine is chemically related to calcium antagonist cinnarizine and flunarizine. The study presented investigates the influence of the drug on the diameter of cortical arteries and cerebral blood velocity measured in the MCA in two groups of anaesthetized cats. Changes of vessel diameter were measured indirectly using photographs of the cerebral cortex during experiments, and flow velocity was measured using transcranial Doppler sonography. Dotarizine was administrated by 20 minute intravenous infusion in a dose of 0.05 mg/kg/min. In the first group of animals the infusion was started during normoventilation, in the next group the infusion started during 30th minute of hyperventilation. The most conspicuous data were obtained in experiments conducted in hyperventilated animals where dotarizine abolished the vasoconstrictive effect of hyperventilation. The results suggest that dotarizine has a pronounced effect on basal as well as cortical arteries of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410624
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effect of Oral Administration of Dotarizine on Cerebrovasculature Subjected to Constriction Followed by Dilatation in Rabbits (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1209-1212 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Ca+2-channel blocker; cerebrovascular reactivity; hyperventilation; anoxia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ In the study presented the effect of Dotarizine on blood flow velocity in cerebral arteries – in middle cerebral artery (MCA), and basilar artery (BA)- was investigated and compared utilising transcranial Doppler sonography during normoventilation, 15 min hyperventilation with subsequent 3 min anoxia in anaesthetized rabbits. In the Dotarizine treated group (12 rabbits) 25 mg/kg of Dotarizine dissolved in 0,25% agar was admistered orally for five days twice daily. In the control group (9 rabbits) animals were fed with agar of the same concentration. The results revealed that decrease of flow velocity caused by hyperventilation and increase during anoxia were less pronounced in the Dotarizine treated group than in control group of animals. A difference between changes of flow velocity in MCA and BA during anoxia was found and the different reactivity of both vessels was established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050420
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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