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  • 1995-1999  (3)
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  • 1
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinical efficiency of mitigating contact dermatitis with a Ginkgo biloba extract and carboxyme-thyl-β-1,3-glucan formulation was investigated in a double-blind versus placebo study using 22 subjects (Caucasian women aged 22–55 years) with allergic contact dermatitis from various substances in the European standard series. The formulation was applied to intact skin 2× a day for 2 weeks (“in use” application) prior to a single application of a selected contact allergen under a Finn Chamber for 24 h. Readings were carried out in a blind study by a dermatologist 2 and 3 days after patch removal. Representative photographs were taken of treated, placebo and untreated test areas. 68.2% of the panelists showed significantly reduced skin reactivity (p= 0.037*) on the treated site 2 days after patch removal, versus untreated and/or placebo sites. This finding indicates that the Ginkgo biloba/carboxymethyl-β-1,3-glucan formulation can mitigate against allergic contact dermatitis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Facial aging is accompanied by modifications in the tensile properties and contours of skin. In the present study we instrumentally assessed and compared the effect of either 0.04% retinol (ROL), 1% melibiose and 4% lactose (ME-L) and their association (ROL-ME-L) to increase the firmness and smoothness of facial skin. A 1 % salicylic acid (SA) emulsion served as a cosmetic product reference.Methods: A total of 120 women were allocated to four randomized groups of 30 subjects, each group receiving one of the test products or a combination of test products. The tensile properties of facial skin were measured using the Cutometer® on seven occasions during the 12-week treatment and during a 4-week post-treatment phase. Fine lines and wrinkles were assessed on replicas by using image analysis after optical shadowing.Results: Significant differences in efficacy and lingering activity were observed between products. SA brought the weakest beneficial effects. ROL and ME-L provided better efficacy on both the tensile properties and contours of skin. They differed slightly according the nature of the biometrological variables. The combination ROL-ME-L achieved similar or even better results than the best of its components for each given physical property of skin.Conclusions: ROL, ME-L, and ROL-ME-L formulations improve physical properties of skin that are impaired by aging. Their activities are notably superior to those of a comparative SA formulation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 39 (1998), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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