ISSN:
0899-0042
Keywords:
β-lactams
;
carbapenem antibiotics
;
titanium enolates
;
imines
;
stereoselective synthesis
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active β-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate. Chirality 10:91-94, 1998. © 1997 Wiley-Liss, Inc.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.15
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