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  • 1
    Electronic Resource
    Electronic Resource
    Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas (1997)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 31 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Very recent multidisciplinary investigations have allowed for the definition among lipomas of a clinical and histological subtype called spindle cell and/or pleomorphic lipoma, possibly associated with partial monosomy 16 and anomalies of chromosome 13. In order to get nearer to the underlying critical molecular changes further multidisciplinary pathological and genetic research is indicated, to identify which chromosome(s) anomalies are crucial in the development of these tumours.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and results:In an ongoing multidisciplinary study of lipomatous tumours, including clinical findings, morphology, histochemistry and cytogenetics, two instances were found of spindle cell lipoma with clonal chromosome changes. In both cases chromosome 13 was involved, whereas only one showed a partial monosomy 16.〈section xml:id="abs1-3"〉〈title type="main"〉Conclusions:Partial monosomy 16 is a characteristic lesion in spindle cell lipoma, usually associated with anomalies of chromosome 13. The present report confirming a previous single observation indicates, however, that lesions of 13 may occur independently from lesions of 16, suggesting different underlying molecular lesions in these otherwise very similar lipomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.2450851.x
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  • 2
    Electronic Resource
    Electronic Resource
    Solitary fibrous tumour of the pleura with t(4;15)(q13;q26) (1999)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 35 (1999), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1999.0728h.x
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  • 3
    Electronic Resource
    Electronic Resource
    Proliferative myositis in a child (1999)
    Springer
    Skeletal radiology 28 (1999), S. 703-709 
    Details
    ISSN: 1432-2161
    Keywords: Key words Proliferative myositis ; Childhood ; Lumbar muscles ; Ossification ; X-ray ; CT ; MRI ; PET
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A case of proliferative myositis in the lumbar paraspinal muscles in a 14-year-old boy is presented. Imaging investigations including plain radiograph, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), bone scan and positron emission tomography (PET) were suggestive of an inflammatory process such as myositis ossificans. The diagnosis was made by incisional biopsy. More pronounced edema, more muscle fiber necrosis and a higher cellularity were found compared to adult cases. The karyotype of the lesion was normal. Clinically, the mass disappeared spontaneously. After 24 months, asymptomatic bridging ossification between the third and fourth lumbar vertebrae was noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050577
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  • 4
    Electronic Resource
    Electronic Resource
    Synovial chondromatosis: clonal chromosome changes provide further evidence for a neoplastic disorder (1998)
    Springer
    Virchows Archiv 433 (1998), S. 189-191 
    Details
    ISSN: 1432-2307
    Keywords: Key words Synovial chondromatosis ; Chromosomes ; Karyotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Synovial chondromatosis is a rare lesion, which is still believed by most authors to be reactive rather than neoplastic. We report on a case of synovial chondromatosis with clonal chromosomal changes [43,XX,der (1) t (1;13) (p21–22;q21),-6,-13,-14, add(21) (q21)]. The presence of clonal chromosomal changes in this and in three previously reported cases suggests that synovial chondromatosis is a true neoplastic lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050235
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  • 5
    Electronic Resource
    Electronic Resource
    Clonal chromosomal changes in juxta-articular myxoma (1999)
    Springer
    Virchows Archiv 434 (1999), S. 177-180 
    Details
    ISSN: 1432-2307
    Keywords: Key words Myxoma ; Juxta-articular ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cytogenetic analysis of a juxta-articular myxoma revealed two distinct cytogenetically abnormal cell populations: inv(2)(p15q36) and +7, t(8;22)(q11–12; q12–13). These clonal chromosomal changes, the first to be reported in this tumour type, suggest that at least some juxta-articular myxomas are neoplastic rather than reactive in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050323
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  • 6
    Electronic Resource
    Electronic Resource
    Intramuscular mixed tumour with clonal chromosomal changes (1999)
    Springer
    Virchows Archiv 434 (1999), S. 167-171 
    Details
    ISSN: 1432-2307
    Keywords: Key words Soft tissue ; Neoplasm ; Mixed tumour ; Pleomorphic adenoma ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A case of an entirely intramuscular mixed tumour occurred in an 82-year-old man, who presented with a large mass in the region of the right triceps muscle. A lobulated tumour was seen, with plump, round epithelioid cells embedded in a chondromyxoid stroma. Immunohistochemical examination showed strong S100 protein and pancytokeratin positivity in most of the tumour cells. Cytogenetic analysis revealed complex clonal chromosomal changes: 47, XY, +i (2) (q10), –15, der (17)t(15;17) (q11; p12), +r. Differential diagnosis against extraskeletal myxoid chondrosarcoma (EMC) may be problematic, particularly in an incisional biopsy. Chromosomal analysis can be very helpful in solving this problem, since EMC shows a specific reciprocal chromosome translocation characterised as t (9;22) (q22–31) (q11–12).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050321
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    Paper (German National Licenses)
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