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  • 1
    Electronic Resource
    Electronic Resource
    Skeletal changes after long-term therapy with synthetic retiiioids (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1997.tb14973.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ferrochelatase activities in patients with erythropoietic protoporphyria and their families (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Ferrochelatase, estimated as zinc chelatase, was measured in the lymphocytes of 30 patients with erythropoietic protoporphyria (EPP), in 35 first- or second-degree relatives of patients with EPP, and in 50 healthy controls. In 30 EPP patients the zinc chelatase level (mean ± standard deviation, SD) was 0–45 ± 0·10 nmol of zinc protoporphyrin per hour per milligram of protein, in 14 EPP carriers the zinc chelatase level (mean ± SD) was 0·42 ± 0·09 and in 50 healthy controls the zinc chelatase level (mean ± SD) was 0–84 ± 0·27. All patients with EPP were also demonstrated to have an elevated protoporphyrin level in their red blood cells: the erythrocyte protoporphyrin levels were as follows EPP patients (mean ± SD) 1300 ± 758 nmol protoporphyrin/dl, EPP carriers (mean ± SD) 60 ± 24, and healthy controls (mean ± SD) 50 ± 25 (P 〈 0·001 for EPP patients compared to controls and EPP carriers).The families of 12 out of 15 EPP patients were examined with respect to the mode of inheritance of the disorder. Of 35 relatives, 14 were carriers of EPP, as characterized by reduced zinc chelatase activity in lymphocytes and by a normal protoporphyrin level in red blood cells. None of the 14 EPP carriers had presented with clinical symptoms of EPP. The mode of inheritance was autosomal dominant in seven of the 12 examined families, and autosomal recessive in two. In two families only one parent could be investigated, but we nevertheless concluded that the inheritance was autosomal dominant. Inheritance in one EPP family could not be elucidated as both parents showed normal zinc chelatase levels and did not demonstrate abnormal erythrocyte protoporphyrin levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.121856.x
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  • 3
    Electronic Resource
    Electronic Resource
    Toxic epidermal necrolysis (Lyell syndrome) following famotidine administration (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02765.x
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  • 4
    Electronic Resource
    Electronic Resource
    PUVA therapy in disabling pansclerotic morphoea of children (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb00738.x
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  • 5
    Electronic Resource
    Electronic Resource
    Palmoplantar keratoderma with an unusual composition of stratum corneum and serum sterol derivatives: a new entity? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Little is known about the aetiology and pathogenesis of the different types of inherited and acquired palmoplantar keratodermas. We describe a condition of painful palmoplantar keratoderma with an altered stratum corneum lipid pattern which may be responsible for the excessive cornilication. Plantar stratum corneum lipids were analysed by quantitative thin-layer chromatography. Serum lipids, and the activities and gene loci of the enzymes serum steroid sulphatase and arylsulphatase C were also determined. Examination revealed that both the stratum corneum and the serum cholesterol sulphate (CS) content were significantly elevated in comparison with the stratum corneum cholesterol ester content. The cholesterol content was unchanged compared with controls. Serum activities of steroid sulphatase and arylsulphatase C were decreased, but not to the extent found in recessive X-linked ichthyosis. Their gene loci did not show any deletions.This unique distribution of stratum corneum sterol derivatives, reflected by the elevated serum CS concentration, may contribute to the altered structural and functional properlies of intercellular lipid lamellae within the stratum corneum of this type of keratoderma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02721.x
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of UVA and UVB irradiation on hepatic and cutaneous P450 isoenzymes (1996)
    Springer
    Archives of dermatological research 289 (1996), S. 46-51 
    Details
    ISSN: 1432-069X
    Keywords: Key words UVA irradiation ; UVB irradiation ; Cutaneous P450 isoenzymes ; Hepatic P450 isoenzymes ; Porphyrin metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of UVA and UVB irradiation of the skin for 1, 2 and 4 weeks on the activities of the hepatic and cutaneous P450 isoenzymes was investigated in female Wistar rats before and after systemic administration of hexachlorobenzene (HCB), a well-known porphyrogenic agent, which additionally induces P450 1A1 and P450 1A2 isoenzymes. UVA and UVB irradiation of the skin of the controls and HCB-treated animals did not influence porphyrin metabolism. In the nonporphyric rats hepatic EROD (P450 1A1) activity was induced by UVB, but the activity of ADM (P450 2B) and EMDM (P450 3A) was either minimally or not affected. In the HCB-treated (porphyric) rats UVA and UVB irradiation resulted in a significant depression of HCB-induced EROD in the liver and in the skin. In both the nonporphyric and the porphyric rats UVA and UVB irradiation had no effect on hepatic ADM activity. In the liver of the nonporphyric animals EMDM activity remained unchanged after UVA and UVB irradiation, whereas in the HCB-treated animals the activity of this enzyme was increased. Finally, after UVA and UVB irradiation cutaneous EMDM activity was increased in the controls, whereas the HCB-induced increase of this enzyme in porphyric animals was decreased. In addition long-term (28 days) UVB irradiation decreased hepatic GSH content significantly in normal and porphyric rats. These experimental findings cannot be directly extrapolated to humans; however, they suggest that exposure of human skin to UV radiation may result in alterations in the activity of cutaneous, hepatic and other extracutaneous P450 isoenzymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050151
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  • 7
    Electronic Resource
    Electronic Resource
    Successful Surgery of Multiple Recurrent Basal Cell Carcinomas Guided by Photodynamic Diagnosis (1997)
    Springer
    Aesthetic plastic surgery 21 (1997), S. 437-439 
    Details
    ISSN: 1432-5241
    Keywords: Key words: Basal cell carcinomas—Photodynamic diagnosis—Aminolevulinic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe a 56-year-old Caucasian man with history of multiple regressed basal cell carcinomas. During the last 20 years approximately 200 histologically proven basal cell carcinomas preferentially localized on the face were surgically treated. Several large skin grafts were necessary to cover the extensive tissue defects on the face and scalp. Although all excised tissues were histologically proven to be basal cell carcinomas with tumor-free margins, new tumors developed in proximity to the skin graft margins. The dissemination of the new tumors made it difficult to perform additional invasive operation procedures without influencing the cosmetic result. Thus, we used photodynamic diagnosis to improve detection and demarcation of the neoplastic tissues. This procedure facilitated surgical planning and enabled primary in toto excisions. Surgical trauma and a number of interventions were thus minimized with the consequence of improved cosmetic and functional results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002669900153
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  • 8
    Electronic Resource
    Electronic Resource
    Hautveränderungen und Hauterkrankungen bei Frauen im Alter (1996)
    Springer
    Der Gynäkologe 29 (1996), S. 761-769 
    Details
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei älteren Menschen gehören behandlungsbedürftige Dermatosen und Neoplasien der Haut neben den sichtbaren Zeichen der Hautalterung zu den häufigsten Erkrankungen. Die Zeitalterung der Haut führt meist lediglich zu kosmetischen Beeinträchtigungen. Die sogenannte Licht- oder Umweltalterung kann jedoch durch lebenslange Akkumulation von UV-Bestrahlung und Umweltfaktoren eine Reihe von weit verbreiteten Hauterkrankungen auslösen. Neben benignen Neubildungen sind maligne Veränderungen der Haut wie z. B. das maligne Melanom, das Basaliom oder das spinozelluläre Karzinom und ihre Vorstufen nicht selten. Hinzu kommen eine Reihe von entzündlichen oder chronischen Dermatosen, die sich gehäuft auf altersveränderter Haut einstellen. Um die rechtzeitige Erkennung und Behandlung dieser Hauterkrankungen zu verbessern aber auch um eine Vorbeugung schon bei jungen Patienten zu ermöglichen, werden die charakteristischen Veränderungen der alten Haut dargestellt und therapeutische und präventive Maßnahmen erläutert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001290050077
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