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  • 1
    Electronic Resource
    Electronic Resource
    In vivo formation of prostaglandin E1 and prostaglandin E2in atopic dermatitis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunological and biochemical alterations in atopic dermatitis have been attributed to a deficient conversion of omega-6 fatty acids (i.e. linoleic acid, gamma-linolenic acid, and dihomo-gamma-linolenic acid) to prostaglandin (PG)E1. In patients with atopic dermatitis, however, the formation of PGE1 has not been evaluated so far. We therefore measured plasma concentrations of 15-keto-13.14-dihydro-PGE1 which reflects endogenous PGE1 release, by gas chromatography-mass spectrometry in 31 patients with atopic dermatitis (aged 18-41 years, median 26 years) and in 31 healthy, age and sex-matched control subjects. In order to exclude a metabolic shift from PGE1 to PGE2, we also measured the plasma levels of 15-keto-13, 14-dihydro-PGE2. There was no difference between patients and control subjects with respect to plasma concentrations of 15-keto-13, 14-dihydro.PGE1 (3.9-49.6, median 10.3pg/ml vs. 3.2-80.4, median 8.3pg/ml, P = 0.22), 15-keto-13,14-dihydro-PGE2 (11.6-201.0 median 24.8pg/ml vs. 8.6-201.0.median 19.6 pg/ml, P = 0.10), and the ratio of 15-keto-13,14-dihydro-PGE1 to 15-keto-13.14-dihydro-PGE2 (0.17-1.39, median 0.41 vs.0.2-0.17, median 0.45, P = 0.29). These results indicate that the endogenous formation of both PGE1 and PGE2 is normal in our patients. The results do not confirm the pivotal role that other authors have attributed to a deficient PGE1 formation in the pathogenesis of atopic dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1195.x
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  • 2
    Electronic Resource
    Electronic Resource
    An unusual case of porokeratosis involving the natal cleft: porokeratosis ptychotropica? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb08643.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical evidence for differential distribution of 5α-reductase isoenzymes in human skin (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Antibodies raised against fragments of synthetic peptides of human 5α-reductase isoenzymes 1 (h5αrl) and 2 (h5αr2) were applied to paraffin sections of human skin (scalp, eyelid, lip, breast, scrotum).Immunoreactive sites were differentially distributed, in that h5αrl immunoreactivity was present in the nuclei of cells in the stratum germinativum (basal and lower portion of the spinous layer) of the epidermis, subepithelial tibroblasts, adipocytes, smooth muscle cells of the scrotal tunica dartos, basal cells of sebaceous glands, excretory duct cells of sweat glands, cells of the dermal papilla and fibrous and outer epithelial sheath of hair roots, as well as endothelial cells of small vessels and Schwann cells of cutaneous myelinated nerves. In contrast, immunoreactivity for h5αr2 was found in the cytoplasm of the cells of the spinous layer (and far less intensely in the basal layer) of the epidermis, subepidermal fibrocytes, and especially in subcutaneous adipocytes. Immunoreactivity was strongest in the non-keratinized portion of the inner epithelial sheath and the cuticle of hair follicles, whereas other portions of the hair root were negative. Sweat glands were stained, whereas sebaceous glands showed only weak diffuse immunoreactivily. In mucoculaneous zones, salivary glands and conjunctival epithelium showed immunoreactive cells. Vascular endothelium displayed immunoreactivity only in the genital region. We present experimental evidence for a differential distribution of 5α-reductase isoenzymes in human skin. This might reflect a diversity in the response of different areas of the skin to androgenic challenge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02663.x
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  • 4
    Electronic Resource
    Electronic Resource
    Alopecia areata Teil 2: Therapie (1999)
    Springer
    Der Hautarzt 50 (1999), S. 310-315 
    Details
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Im ersten Teil dieser Arbeit, der in der Märzausgabe des Hautarzt erschienen ist, wurden Klinik, Ätiologie und Pathogenese der Alopecia areata dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050912
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  • 5
    Electronic Resource
    Electronic Resource
    Neonataler Lupus erythematosus und mütterliches HELLP-Syndrom: Gibt es einen pathogenetischen Zusammenhang? (1998)
    Springer
    Der Hautarzt 49 (1998), S. 662-665 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Neonataler Lupus erythematosus ; HELLP-Syndrom ; Antikörper ; Key words Neonatal lupus erythematosus ; HELLP syndrome ; Antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A newborn boy developed annular erythematous lesions on his entire body. Histopathological examination showed typical features of lupus erythematosus. His mother was positive for anti-Ro/SSa and anti-La/SSb antibodies. Neonatal lupus erythematosus was diagnosed. During pregnancy the mother had suffered from HELLP syndrome. The reported case points out the necessity to differentiate HELLP syndrome from first manifestation of lupus erythematosus during pregnancy. A direct causal relationship between neonatal lupus erythematosus and HELLP syndrome of the mother seems to be unlikely.
    Notes: Zusammenfassung Wir berichten über einen Säugling, der im Alter von 8 Wochen anuläre Erytheme am gesamten Integument entwickelte. Histologisch fand sich das typische Bild eines Lupus erythematosus. Im Serum der Mutter ließen sich Anti-Ro/SSA- und Anti-La/SSB-Antikörper nachweisen. Es wurde ein neonataler Lupus erythematosus diagnostiziert. Die Schwangerschaft war durch das Auftreten eines HELLP-Syndroms kompliziert worden. Der dargestellte Fall weist auf die Notwendigkeit hin, ein HELLP-Syndrom differentialdiagnostisch von einer Erstmanifestation eines Lupus erythematosus in der Schwangerschaft abzugrenzen. Ein direkter pathoge-netischer Zusammenhang zwischen neonatalem Lupus erythematosus und HELLP-Syndrom wird für unwahrscheinlich gehalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050806
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  • 6
    Electronic Resource
    Electronic Resource
    Fereydoun Vakilzadeh 60 Jahre (1998)
    Springer
    Der Hautarzt 49 (1998), S. 329-330 
    Details
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050753
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  • 7
    Electronic Resource
    Electronic Resource
    Alopecia areata (1999)
    Springer
    Der Hautarzt 50 (1999), S. 222-239 
    Details
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die Alopecia areata ist nach der androgenetischen Alopezie, die beim Mann eher ein vererbtes Merkmal als eine Krankheit darstellt, die häufigste Form des Haarausfalls. In der Regel verläuft der Haarverlust ohne subjektive Beschwerden, es kommt aber zu gravierenden kosmetischen Folgen, die mitunter zu psychosozialen Problemen führen. Die Ursache der Alopecia areata ist einstweilen unbekannt, eine kausale Behandlung deshalb noch nicht möglich. Neue Forschungsergebnisse erlauben jedoch, Teilaspekte der Pathogenese dieser Erkrankungen zu erkennen. Da die Behandlung mitunter über mehrere Jahre erfolgen muß, sollten mögliche Risiken und therapeutischer Nutzen abgewogen werden. Wegen des unvorhersehbaren Verlaufs der Erkrankung sollten Behandlungserfolge nicht einfach behauptet, sondern vielmehr durch kontrollierte Studien bewiesen werden. Trotz der mitunter lästigen Begleiterscheinungen ist derzeit die topische Immuntherapie als wirkungsvollste Therapie anzusehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050895
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  • 8
    Electronic Resource
    Electronic Resource
    Die pathogenetische Bedeutung der 5α-Reduktase-Isoenzyme für die androgenetische Alopezie (1999)
    Springer
    Der Hautarzt 50 (1999), S. 165-173 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Haare ; Effluvium ; Androgene ; 5α-Reduktase ; Dihydrotestosteron ; Key words Hair ; Hair loss ; Androgens ; 5α-reductase ; Dihydrotestosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Androgenetic alopecia is the most common form of hair loss in men and women. Although clinically different, the pathogenetic pathways leading to this type of hair loss are similar in both sexes. Recent experimental data enable us to explain some pathogenetic steps suggesting a pivotal role of type 2 5α-reductase in the pathogenesis of androgenetic hair loss. In this review our current knowledge about the pathophysiology and treatment options of androgenetic alopecia is summarized.
    Notes: Zusammenfassung Die androgenetische Alopezie ist bei Frauen und Männern die häufigste Form des Haarausfalls. Wenngleich sich der Haarausfall bei Frau und Mann klinisch unterschiedlich manifestiert, so sind dennoch die zugrundeliegenden, zur Alopezie führenden Pathomechanismen dieselben. Es kann davon ausgegangen werden, daß aufgrund genetischer Prägung bestimmte Haarfollikel am Capillitium eine verstärke Sensitivität gegenüber Androgenen aufweisen. Die Forschungsergebnisse der letzten Jahre haben eine Vielzahl pathophysiologisch bedeutsamer Erkenntnisse über die Ausstattung humaner Haarfollikel mit Androgenrezeptoren und androgenmetabolisierender Enzyme hervorgebracht. Insbesondere scheint der Isotyp II der 5α-Reduktase in der Pathogenese der androgenetischen Alopezie eine zentrale Bedeutung zu haben. In dieser Übersicht werden daher die unterschiedlichen Aspekte der 5α-Reduktase-Isoenzyme dargestellt, deren pathogenetische Bedeutung im Rahmen der androgenetischen Alopezie beschrieben und mögliche therapeutische Konsequenzen aufgezeigt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050884
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