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  • 1
    Electronic Resource
    Electronic Resource
    Serum level of major basic protein indicates disease activity in atopic dermatitis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 9 (1997), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the serum levels of major basic protein (MBP), assayed using an MBP radioimmunoassay kit. and the effect of an anti-allergic agent, ketotifen, which has strong anti-eosinophil activity, in 56 atopic dermatitis (AD) patients. The serum MBP level was significantly lower (660.11 ± 34.52 ng/ml, P 〈 0.05) after administration of ketotifen (1 mg twice a day) for 8 weeks than before treatment (774.98 ± 48.64 ng/ml). These findings suggest that serum MBP levels are a useful indicator of AD activity and that anti-allergic agents can have an effect on eosinophil involvement in AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1997.tb00228.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of parent genetic background on latency and antigenicity of UV-induced tumors originating in F1 hybrids (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Wide variations in susceptibility to skin tumor development by chronic ultraviolet light (UV) exposure and antigenicity of induced tumors which is estimated by tumor rejection in syngeneic recipients have been recognized among various murine strains. To examine the effect of parent genetic background on latency and antigenicity of UV-induced tumors originating in F1 hybrids, we induced skin tumors in three mouse strains: BALB/c, C57BL/6, (B6), and C3H/HeMs (C3H/He), and their F1, hybrids: (BALB/c×C3H/He)F1, (CC3F1), (BALB/c×B6)F1, (CB6F1) and (C3H/He×B6)F1, (C3B6F1) by exposing mice to UV radiation (0.44 mW/ cm2 for 1 h) three times a week, and analyzed whether the UV-induccd tumors originating in F1 hybrids possess the similar property in latency or antigenicity as seen in the UV-induced tumors derived from the parent strains. The latency of tumor induction by chronic UV exposure in C3H/He, BALB/c and their F1, hybrid CC3F1, was relatively short whereas that of B6 was relatively long, and that of F1, hybrids with B6 (CB6F, and C3B6F1) was intermediate. On the other hand, the low antigenicity as progressive growth behavior of UV-induced tumors in syngeneic recipients was observed not only in tumors derived from C3H/He but also in those from F, hybrids with C3H/He (C3B6F1, and CC3F1) whereas most tumors derived from B6, BALB/c and their F1 hybrid CC3F1 were highly antigenic as to be rejected in syngeneic recipients. These findings suggest that the parent genetic quality regulating the susceptibility to tumor induction by chronic UV exposure is co-dominantly inherited into F1 hybrids. On the other hand, that providing the progressive growth behavior of induced tumors appears to be a dominant effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1995.tb00220.x
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  • 3
    Electronic Resource
    Electronic Resource
    Leukotriene A4 hydrolase in peripheral leukocytes of patients with atopic dermatitis (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 168-172 
    Details
    ISSN: 1432-069X
    Keywords: Key words Leukotriene A4 hydrolase ; LTB4 ; Leukocyte ; Atopic dermatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the enzymatic activity of leukotriene (LT) A 4 hydrolase, which catalyzes the conversion of LTA 4 to LTB 4 , in peripheral leukocytes of patients with atopic dermatitis. The patients were divided into three categories (severe, moderate and mild) on the basis of clinical severity. The LTA 4 hydrolase activities in the supernatant fraction of peripheral blood polymorphonuclear leukocytes (PMN) were significantly higher in preparations of cells from severe atopic dermatitis patients (123.94 ± 16.61 pmol/10 6 cells per min) than in those from moderate (49.03 ± 9.43 pmol/ 10 6 cells per min; P 〈 0.01) and mild (28.75 ± 11.42 pmol/10 6 cells per min; P 〈 0.01) atopic dermatitis patients and normal controls (15.14 ± 1.74 pmol/10 6 cells per min; P 〈 0.01). LTA 4 hydrolase activities were also higher in peripheral blood mononuclear cells (PBMC) from severe atopic dermatitis patients (27.81 ± 8.28 pmol/10 6 cells per min) than in those from moderate (11.31 ± 2.11 pmol/10 6 cells per min; P 〈 0.05) and mild (6.16 ± 2.62 pmol/10 6 cells per min; P 〈 0.05) atopic dermatitis patients and normal controls (11.17 ± 0.83 pmol/10 6 cells per min; P 〈 0.05). LTA 4 hydrolase activities in PMN were reduced after improvement of the disease in eight patients with severe or moderate atopic dermatitis. These results suggest that LTA 4 hydrolase, which synthesizes LTB 4 , plays a significant role in the pathogenesis and development of atopic dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050041
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  • 4
    Electronic Resource
    Electronic Resource
    Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 175-180 
    Details
    ISSN: 1432-069X
    Keywords: Key words Malignant melanoma ; pl6 ; p15 ; Replication error
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutations of p16 and p15 suppressor oncogenes and the replication errors in six microsatellite loci in sporadic malignant melanomas were analyzed. Four (9.1%) homozygous deletions of both p16 and p15 genes and one point mutation (2.3%) in the p15 gene were detected among 44 primary melanoma samples. One mutation in each of the p16 and p15 genes was observed in ten metastatic lesions. Eight (18.2%) replication errors were detected in three microsatellite loci in the primary melanoma samples, but no replication error was detected in the metastatic samples. None of the samples showed the alteration of p16/p15 genes and the replication errors concomitantly. These results suggest that (1) the homozygous deletions of p16/p15 genes and the replication errors may occur in rather early stages of melanoma tumorigenesis, while the p16/p15 gene mutation may occur in later stages, and (2) the p16 and p15 gene mutations in sporadic malignant melanomas might not be induced by the defect in mismatch repair, implying that p16 as well as p15 gene alterations may play an important role in the pathogenesis of sporadic malignant melanomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050286
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  • 5
    Electronic Resource
    Electronic Resource
    N-cadherin expression in human adult T-cell leukemia cell line (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 223-225 
    Details
    ISSN: 1432-069X
    Keywords: Key words N-cadherin ; Adult T-cell leukemia cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050294
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  • 6
    Electronic Resource
    Electronic Resource
    Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4 (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 347-351 
    Details
    ISSN: 1432-069X
    Keywords: Key words Leukotriene A4 hydrolase ; Leukotriene C4 synthase ; LTB4 ; LTC4 ; LTD4 ; Human melanoma cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the synthesis of leukotrienes (LTs) in human melanoma cells in order to assess the function of LTs in human melanocytes. LTA4 hydrolase, which catalyzes the conversion of LTA4 to LTB4, was detected in the supernatant of cultured human melanoma (MeWo) cells and melanoma cells obtained from patients. Immunoblotting analysis using an antihuman LTA4 hydrolase antibody showed LTA4 hydrolase to be a 70-kDa protein in both MeWo and melanoma cells. Considerable activity of LTC4 synthase, which catalyzes the conversion of LTA4 to LTC4, was detected in the microsomal fraction of both MeWo and melanoma cells. The HPLC profile of the LTC4 synthase reaction products revealed that LTC4 was the main product. LTD4 was not detected under these conditions, indicating that the microsomal fraction of human melanoma cells lacks the membrane-bound γ-glutamyl transferase that converts LTC4 to LTD4. LTC4 synthase activity was inhibited by the additon of MK-886, and was not altered by treatment with N-ethylmaleimide or 1-chloro-2,4-dinitrobenzene. These results indicate that the enzyme responsible for the conversion of LTA4 to LTC4 in human melanoma cells is LTC4 synthase rather than a nonspecific or microsomal glutathione-S-transferase. These results also suggest that human melanoma cells can generate LTB4 and LTC4 from LTA4, and that this process is catalyzed by two enzymes: LTA4 hydrolase and LTC4 synthase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050203
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