Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 1407-1421 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 222-224 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The angle between the benzo[a]phenazin-5-yl and naphthyl rings is 80.42 (7)° and the benzo[a]phenazin-5-yl rings exhibit π-π stacking.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 770 (1995), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 39 (1996), S. 23-29 
    ISSN: 1530-0358
    Keywords: Constipation ; Slow transit ; Colectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study assesses the outcome of a standardized operation performed by two surgeons for severe idiopathic slow transit constipation that was resistant to laxative treatment. METHODS: Fifty-nine consecutive patients, 4 men and 55 women, with a mean age of 42.3 years, underwent colectomy with ileorectal anastomosis. Slow colonic transit was demonstrated in each case. Fifty-two patients were available for follow-up, with median time to follow-up being 42 (range, 3–81) months. RESULTS: Median bowel frequency was 4 per 24 hours. Sixty-nine percent had four or less bowel movements daily. Ten percent used antidiarrheal medication regularly. One patient had a stoma for recurrent severe constipation. Mean continence score was 1.8 (on a scale of 0–20); six patients were incontinent, and four of these six had normal preoperative anal manometry. Fourteen patients (27 percent) had difficulty with rectal evacuation. Preoperative defecating proctography was a poor predictor of postoperative evacuation difficulties. Twenty-seven patients (52 percent) had persisting abdominal pain, but there was a significant improvement in the degree of pain (P 〈0.00001). Forty-seven patients (90 percent) were satisfied with the outcome of the operation (and would elect to have it done again). Dissatisfied patients had recurrent constipation or diarrhea and incontinence. CONCLUSION: Colectomy with ileorectal anastomosis produces a satisfactory functional outcome in the majority of patients undergoing surgery for severe constipation with proven slow colonic transit.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 42 (1999), S. 1000-1006 
    ISSN: 1530-0358
    Keywords: Glyceryl trinitrate ; Anal fissure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: A randomized, double-blind, placebo-controlled trial was performed to test the effect of intra-anal glyceryl trinitrate ointment in patients with chronic anal fissures that would normally have been treated by sphincterotomy. Long-term follow-up was then performed to assess fissure healing. METHODS: Patients with chronic anal fissures were randomly assigned to 0.2 percent topical glyceryl trinitrate ointment or placebo. Anal manometry was performed before treatment, one week later, and 48 hours after treatment ceased at four weeks. Fissure healing was assessed by an observer blinded to the treatment arm. Pain was recorded on a linear analog scale. At the completion of the trial, treatment was continued with glyceryl trinitrate until fissure healing was obtained or lateral sphincterotomy was performed if required for ongoing pain. A long-term follow-up assessment was made at a mean of 29 (range, 25–33) months. RESULTS: There was a significant reduction in anal resting pressure at Week 1 with glyceryl trinitrate (P=0.001) but not placebo, and at Week 4 there was a significant reduction in pain score with glyceryl trinitrate (P=0.001) and placebo (P=0.01) and a significant reduction in fissure grade with glyceryl trinitrate (P=0.0001) and placebo (P=0.02). Forty-six percent of fissures healed with glyceryl trinitrate and 16 percent healed with placebo (P=0.001). At long-term follow-up in 40 of 43 patients, 14 patients (35 percent) had undergone lateral sphincterotomy, and in the remainder who were treated with glyceryl trinitrate there was a significant reduction in pain score (P=0.0002). Seventeen patients attended for repeat manometry and fissures were healed with glyceryl trinitrate in ten (59 percent) cases. High internal sphincter pressures persisted at long-term follow-up in patients successfully treated with glyceryl trinitrate, indicating that the sphincter is the cause rather than effect of anal fissure. CONCLUSION: Topical glyceryl trinitrate produces a successful internal sphincterotomy, which resulted in long-term healing of 59 percent of chronic anal fissures and significant improvement in pain. Internal sphincter spasm is the cause of chronic anal fissure.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 456-475 
    ISSN: 1476-5535
    Keywords: Keywords: medium design; medium optimization; fermentation; gamma-linolenic acid; neural networks; fuzzy logic; genetic algorithms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Many techniques are available in the fermentation medium designer’s toolbox (borrowing, component swapping, biological mimicry, one-at-a-time, statistical and mathematical techniques—experimental design and optimization, artificial neural networks, fuzzy logic, genetic algorithms, continuous fermentation, pulsed batch and stoichiometric analysis). Each technique has advantages and disadvantages, and situations where they are best applied. No one ‘magic bullet’ technique exists for all situations. However, considerable advantage can be gained by logical application of the techniques, combined with good experimental design.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-0843
    Keywords: Key words Chemotherapy ; Doxorubicin ; Metastatic breast cancer ; Methotrexate ; Vinorelbine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: This study was performed to determine the maximum tolerated dose (MTD) and toxicity of vinorelbine when used in combination with doxorubicin and methotrexate with leucovorin rescue in women with metastatic breast cancer. Methods: Enrolled in the study were 23 women with metastatic breast cancer who had not received prior chemotherapy for metastatic disease. Patients treated at the first dose level received vinorelbine 20 mg/m2 on day 1, doxorubicin 40 mg/m2 on day 1, methotrexate 100 mg/m2 on day 1 and leucovorin 20 mg orally every 6 h for six doses beginning on day 2. Treatment was repeated every 21 days. The vinorelbine dose was escalated by 5 mg/m2 for patients treated at subsequent dose levels. The MTD was defined as the dose level at which fewer than one-third of patients enrolled experienced dose-limiting toxicity (DLT). When the MTD of vinorelbine had been determined, the doxorubicin dose was then escalated by 10 mg/m2 with the vinorelbine dose held at its MTD. Results: total of 98 courses of treatment (median of 4 per patient, range 2–8) were administered. The MTD of this regimen was found to be vinorelbine 25 mg/m2, doxorubicin 40 mg/m2, and methotrexate 100 mg/m2 with leucovorin rescue. At higher doses of vinorelbine, neutropenia, fatigue, arm pain, malaise, nausea and vomiting were dose-limiting. Higher doses of doxorubicin resulted in universal dose limiting neutropenia, and frequent nonhematologic DLT consisting of arm pain, malaise, stomatitis, nausea and vomiting. Amongst the 20 patients with measurable disease, there were 3 complete responses (15%, 95% confidence interval 3%–38%), 5 partial responses (25%, 95% confidence interval 9%–49%) and an overall response rate of 40% (95% confidence interval 19%–64%). The median survival was estimated to be 25 months from the start of chemotherapy. Conclusions: Vinorelbine at 25 mg/m2 can be safely administered with doxorubicin at 40 mg/m2 and methotrexate at 100 mg/m2 with leucovorin rescue. Response rates observed with this regimen suggest that this combination of chemotherapeutic agents may not be more effective than the combination of vinorelbine and doxorubicin.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 11 (1996), S. 29-33 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats de tests de l'électrosensibilité de la muqueuse rectale ont été utilisés pour soutenir des théories concernant l'étiologie à la fois de la constipation idiopathique et des dysfonctionnements coliques après rectopexie. Le but de cette étude était de déterminer la validité des tests de l'électro-sensibilité de la muqueuse rectale. Soixante huit patients comprenant 3 groupes (groupe 1: 50 patients soumis à une évaluation dans l'unité de physiologie ano-rectale, groupe 2: 10 patients porteurs d'anastomose colo-anale ou iléo-anale, groupe 3: 8 patients porteurs de stomie) ont été soumis à des tests d'électrosensibilité de la muqueuse rectale avec enregistrement du seuil de stimulation nécessaire pour entrainer une perception. Par ailleurs, l'électrosensibilité de la muqueuse rectale a été mesuréc dans les groupes 1 et 2 en plaçent l'électrode, montée sur un cathéter avec un guide central métallique, contre la paroi antérieure, postérieure, droite et gauche du rectum ou du néo-rectum. Pour déterminer les répercussions sur ce test d'une perte du contact muqueux résultant de la présence de matières fécales, un groupe de 8 patients avec un rectum normal a été testé avec une électrode entourée ou non d'une gaze imprégnée d'eau afin de simuler la présence de matières fécales et de prévenir un contact direct de l'électrode avec la muqueuse rectale. Une grande disparité dans la sensibilité des différentes régions du rectum a été mise en évidence (P〈0.0001). Dans le groupe 1, les seuils moyens étaient de 36,6 mA, sur la paroi antérieure 27,4 mA, la paroi postérieure 37,9 mA, du côté droit 22,3 mA et du côté gauche 25,6 mA. Ces variàtions dans la circonférence suggèrent que c'est davantage le plancher pelvien que la muqueuse rectale qui a été stimulé. Chez tous les patients du groupe 2, les seuils de sensibilité ont été enregistrés et la valeur moyenne était significativement plus élevée que dans les patients du groupe 1 en position centrale (P=0.003), du côté droit (P=0.003) et du côté gauche (P=0.007). Dans le groupe 3, la sensibilité était plus élevée à l'intérieur du stoma, autant au niveau de la musculature de la paroi abdominale qu'au niveau intra-colique ou sous-cutané, suggérant ainsi une origine extra-colique à la perception. Le seuil de sensibilité était significativement plus élevé lorsque l'électrode était enveloppéee de gaze (P〈0.001) et la perte du contact avec la muqueuse n'a pas été détectée par l'appareil d'EMG. En conclusion, la mesure de l'électrosensibilité de la muqueuse rectale ne semble done pas correspondre à une mesure au niveau de la muqueuse et est probablement influencée par le présence de matières fécales.
    Notes: Abstract The results of rectal mucosal electrosensitivity (RME) testing have been used to support theories regarding the aetiology of both idiopathic constipation and bowel dysfunction following rectopexy. The aim of this study was to assess the validity of tests of RME. Sixty-eight patients, comprising three groups (group 1: 50 patients undergoing assessment in the Anorectal Physiology Unit, group 2: 10 patients with coloanal or ileoanal anastomosis, group 3: 8 patients with a stoma) underwent mucosal electrosensitivity testing, with the threshold stimulus required to elicit sensation being recorded. In addition the RME was measured in groups 1 and 2 when placing the electrode, mounted on a catheter with a central wire, against the anterior, posterior, right and left rectal or neorectal walls. To assess the influence on this test of loss of mucosal contact due to faeces, a further 8 cases with a normal rectum had RME performed with and without a layer of water soaked gauze around the electrode to stimulate faeces and prevent the electrode from making contact with the rectal mucosa. There was marked variance in the sensitivity of the different regions of rectal wall tested (P〈0.0001). In group 1 patients the mean sensitivities were: central 36.6 mA, anterior 27.4 mA, posterior 37.9 mA, right 22.3 mA and left 25.6 mA. This circumferential variation suggests that the pelvic floor rather than rectal mucosa was being stimulated. All patients in group 2 had recordable sensitivities, and the mean sensitivity threshold was significantly higher than group 1 patients in the central (P=0.03), right (P=0.03) and left (P=0.007) positions. In group 3 the sensitivity was greater within the stoma at the level of the abdominal wall muscle than intraabdominally or subcutaneously, again suggesting an extra-colonic origin of the sensation. The sensitivity thresh-old was significantly greater with the electrode wrapped in gauze (P〈0.01), and loss of mucosal contact was not detected by the EMG machine. Therefore RME testing would seem not to measure mucosal sensitivity, and is probably influenced by the presence of faeces.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 11 (1996), S. 29-33 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Les résultats de tests de l'électrosensibilité de la muqueuse rectale ont été utilisés pour soutenir des théories concernant l'étiologie à la fois de la constipation idiopathique et des dysfonctionnements coliques après rectopexie. Le but de cette étude était de déterminer la validité des tests de l'électro-sensibilité de la muqueuse rectale. Soixante huit patients comprenant 3 groupes (groupe 1: 50 patients soumis à une évaluation dans l'unité de physiologie ano-rectale, groupe 2: 10 patients porteurs d'anastomose colo-anale ou iléo-anale, groupe 3: 8 patients porteurs de stomie) ont été soumis à des tests d'électrosensibilité de la muqueuse rectale avec enregistrement du seuil de stimulation nécessaire pour entrainer une perception. Par ailleurs, l'électrosensibilité de la muqueuse rectale a été mesurée dans les groupes 1 et 2 en plaçent l'électrode, montée sur un cathéter avec un guide central métallique, contre la paroi antérieure, postérieure, droite et gauche du rectum ou du néo-rectum. Pour déterminer les répercussions sur ce test d'une perte du contact muqueux résultant de la présence de matières fécales, un groupe de 8 patients avec un rectum normal a été testé avec une électrode entourée ou non d'une gaze imprégnée d'eau afin de simuler la présence de matières fécales et de prévenir un contact direct de l'électrode avec la muqueuse rectale. Une grande disparité dans la sensibilité des différentes régions du rectum a été mise en évidence (P 〈 0.0001). Dans le groupe 1, les seuils moyens étaient de 36,6 mA, sur la paroi antérieure 27,4 mA, la paroi postérieure 37,9 mA, du côté droit 22,3 mA et du côté gauche 25,6 mA. Ces variàtions dans la circonférence suggèrent que c'est davantage le plancher pelvien que la muqueuse rectale qui a été stimulé. Chez tous les patients du groupe 2, les seuils de sensibilité ont été enregistrés et la valeur moyenne était significativement plus élevée que dans les patients du groupe 1 en position centrale (P = 0.003), du côté droit (P = 0.003) et du côté gauche (P = 0.007). Dans le groupe 3, la sensibilitéétait plus élevée à l'intérieur du stoma, autant au niveau de la musculature de la paroi abdominale qu'au niveau intra-colique ou sous-cutané, suggérant ainsi une origine extra-colique à la perception. Le seuil de sensibilitéétait significativement plus élevé lorsque l'électrode était enveloppéee de gaze (P 〈 0.001) et la perte du contact avec la muqueuse n'a pas été détectée par l'appareil d'EMG. En conclusion, la mesure de l'électrosensibilité de la muqueuse rectale ne semble donc pas correspondre à une mesure au niveau de la muqueuse et est probablement influencée par le présence de matières fécales.
    Notes: Abstract. The results of rectal mucosal electrosensitivity (RME) testing have been used to support theories regarding the aetiology of both idiopathic constipation and bowel dysfunction following rectopexy. The aim of this study was to assess the validity of tests of RME. Sixty-eight patients, comprising three groups (group 1: 50 patients undergoing assessment in the Anorectal Physiology Unit, group 2: 10 patients with coloanal or ileoanal anastomosis, group 3: 8 patients with a stoma) underwent mucosal electrosensitivity testing, with the threshold stimulus required to elicit sensation being recorded. In addition the RME was measured in groups 1 and 2 when placing the electrode, mounted on a catheter with a central wire, against the anterior, posterior, right and left rectal or neorectal walls. To assess the influence on this test of loss of mucosal contact due to faeces, a further 8 cases with a normal rectum had RME performed with and without a layer of water soaked gauze around the electrode to stimulate faeces and prevent the electrode from making contact with the rectal mucosa. There was marked variance in the sensitivity of the different regions of rectal wall tested (P 〈 0.0001). In group 1 patients the mean sensitivities were: central 36.6 mA, anterior 27.4 mA, posterior 37.9 mA, right 22.3 mA and left 25.6 mA. This circumferential variation suggests that the pelvic floor rather than rectal mucosa was being stimulated. All patients in group 2 had recordable sensitivities, and the mean sensitivity threshold was significantly higher than group 1 patients in the central (P = 0.03), right (P = 0.03) and left (P = 0.007) positions. In group 3 the sensitivity was greater within the stoma at the level of the abdominal wall muscle than intra-abdominally or subcutaneously, again suggesting an extra-colonic origin of the sensation. The sensitivity threshold was significantly greater with the electrode wrapped in gauze (P 〈 0.01), and loss of mucosal contact was not detected by the EMG machine. Therefore RME testing would seem not to measure mucosal sensitivity, and is probably influenced by the presence of faeces.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 4 (1997), S. 292-297 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Residual dipolar couplings observed in NMR spectra at very high magnetic fields have been measured to a high degree of accuracy for the paramagnetic protein cyanometmyoglobin. Deviations of these measurements from predictions based on available crystallographic and solution structures are largely ...
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...