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  • 1
    Electronic Resource
    Electronic Resource
    Epithelial cell proliferation and gene mutation in the mucosa of gallbladder with pancreaticobiliary malunion and cancer (1999)
    Springer
    Journal of hepato-biliary-pancreatic surgery 6 (1999), S. 229-236 
    Details
    ISSN: 1436-0691
    Keywords: Key words: pancreaticobiliary malunion ; epithelial hyperplasia ; gallbladder cancer ; genetic alteration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The significant association between pancreaticobiliary malunion (PBM), especially undilated-type PBM, and a high risk of gallbladder cancer is known. Reflux and stasis of pancreatic juice induce various epithelial changes in the gallbladder. Recently, epithelial hyperplasia of the gallbladder was shown to be significantly and frequently associated with undilated-type PBM, and it is suggested that the majority of epithelial hyperplasia may exist at birth or be acquired in early childhood, and thereafter present throughout the lives of PBM patients. Cell kinetic studies demonstrated a significant stepwise increase in cellular proliferative activity from normal gallbladder mucosa, through epithelial hyperplasia to cancer. Epithelial hyperplasia with increased proliferative activity may predispose the mucosa to mutational events, thereby increasing cancer risk in PBM patients. K-ras mutations were frequently detected in gallbladder cancer in PBM patients and in epithelial hyperplasia as well. Epithelial hyperplasia is demonstrated to be an important premalignant lesion of gallbladder cancer. A multistep process of carcinogenesis as a consequence of multiple genetic alterations of oncogenes and tumor suppressor genes has been demonstrated in various organs; however, there is limited information on the molecular mechanism in gallbladder carcinogenesis with PBM. Recent findings support the idea that epithelial hyperplasia plays an important role in gallbladder carcinogenesis with PBM and also support the concept that neoplastic development in gallbladder with PBM also evolves through a multistep process associated with hyperproliferation and genetic alterations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050112
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  • 2
    Electronic Resource
    Electronic Resource
    Splenic hamartoma associated with thrombocytopenia (1997)
    Springer
    Journal of gastroenterology 32 (1997), S. 114-118 
    Details
    ISSN: 1435-5922
    Keywords: hamartoma ; spleen ; thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of splenic hamartoma associated with thrombocytopenia is reported. A 70-year-old man was referred to our hospital because of carcinoma of the body of the pancreas. Hematological examination disclosed thrombocytopenia and elevated serum CA19-9 and Span-1 levels. In addition to typical findings of pancreatic carcinoma, a solid mass was observed in the spleen by imaging procedures. On ultrasonography, the splenic mass was well demarcated and slightly hypoechoic. Computed tomography demonstrated a homogeneous low-density mass 5 cm in diameter. On T1- and T2-weighted magnetic resonance images, the splenic mass was demonstrated as low intensity and high intensity, respectively. On selective angiography, the tumor was hypervascular. Distal pancreatectomy plus splenectomy was performed. Microscopically, the splenic tumor consisted of red pulp tissue and was diagnosed as splenic hamartoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01213307
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  • 3
    Electronic Resource
    Electronic Resource
    Autoantibody against a 78 kDa membrane protein of HepG2 cell in the sera of patients with alcoholic liver diseases (1995)
    Springer
    Journal of gastroenterology 30 (1995), S. 751-757 
    Details
    ISSN: 1435-5922
    Keywords: alcoholic liver diseases ; autoantibody ; HepG2 cells ; 125I-protein A binding assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sera from 14 normal control subjects, 30 patients with alcoholic liver diseases (fatty liver,n=8; hepatitis,n=13; liver cirrhosis,n=9), 7 controls with chronic hepatitis B, and 8 controls with chronic hepatitis C were masured for their concentrations of antibodies against HepG2 membrane protein by a binding assay utilizing125I-labeled protein A. When the cut-off level was set as the mean value plus 2 SD of normal control subjects, the incidence of positivity was 75%, 69.2%, and 77.8% in patients with alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis, respectively. Both the mean serum antibody values and the positive incidence were significantly higher in patients with alcoholic liver diseases than in either the normal controls or in the control patients with chronic hepatitis. Sodium dodecylsulfate polyacrylamide gel electrophoresis of125I-labeled HepG2 membrane protein precipitated with IgG from patients with alcoholic liver diseases revealed an immunoreactive band at a molecular weight of 78 000 daltons (gp78). The antibody activity remained after immunoabsorption by human liver-specific lipoprotein (LSP) but decreased when HepG2 cells were pre-treated with trypsin or neuraminidase. Consequently, gp78 appears to be a glycoprotein distinct from LSP, and is specifically recognized by IgG from patients with alcoholic liver diseases. This assay may provide a new system to measure autoantibody to hepatocytes in alcoholic liver diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02349642
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  • 4
    Electronic Resource
    Electronic Resource
    Primary biliary cirrhosis associated with idiopathic thrombocytopenic purpura (1996)
    Springer
    Journal of gastroenterology 31 (1996), S. 284-288 
    Details
    ISSN: 1435-5922
    Keywords: primary biliary cirrhosis ; idiopathic thrombocytopenic purpura ; platelet-associated IgG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of primary biliary cirrhosis (PBC) associated with idiopathic thrombocytopenic purpura (ITP) is reported. The patient is a 59-year-old man. When he was 49 years old, he was diagnosed with ITP and received steroid therapy that successfully increased platelet numbers. However, the steroid therapy failed to normalize the elevated gamma-glutamyl transpeptidase. Ten years after this episode, he suffered from general itching and malaise and exhibited a gradual increase of serum biliary enzyme levels. Immunologically, IgM was increased and anti-mitochondrial antibody was positive. Histological findings of liver needle biopsy showed chronic non-suppurative destructive cholangitis, confirming the diagnosis of PBC. To date, very few PBC cases associated with ITP have been reported. Our case is the second one in Japan. PBC and ITP in our patient seemed to develop simultaneously, but the effect of steroid therapy on the two conditions was different. This result suggests that the autoimmune process may have been different in PBC and ITP in the present patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389532
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  • 5
    Electronic Resource
    Electronic Resource
    Segmental groove pancreatitis accompanied by protein plugs in Santorini's duct (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 289-294 
    Details
    ISSN: 1435-5922
    Keywords: Key words: groove pancreatitis ; Brunner's gland ; protein plug ; Santorini's duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: "Groove pancreatitis", a form of segmental pancreatitis affecting the head of the pancreas, is local-ized within the "groove" between pancreas head, duo-denum, and common bile duct. Differentiation between groove pancreatitis and pancreatic head carcinoma is often difficult. We report a case of groove pancreatitis in which a hypoechoic mass between the duodenal wall and pancreas was clearly imaged, and narrowing of the second portion of the duodenum and bile duct stenosis were also found. The diagnosis was confirmed by surgery (pylorus-preserving pancreato duodenectomy). The patient was relieved from abdominal pain post operation. Up to the present, the patient has been good condition. We review the clinicopathologic and radiologic features of groove pancreatitis in the Japanese literature and discuss the possible role of Santorini's duct in its pathogenesis. We consider that impacted protein plugs in Santorini's duct are a pathogenic factor in the development of groove pancreatitis. Therefore, the findings of Santorini's duct on endoscopic retrograde pancreatography are very important in the diagnosis of groove pancreatitis. Groove pancreatitis presents various clinical features, such as biliary stenosis, duodenal stenosis, and pancreatic mass, and often masquerades as pancreatic head carcinoma. This condition should be kept in mind in the differential diagnosis of pancreatic head carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050086
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production (1995)
    Springer
    Cancer immunology immunotherapy 40 (1995), S. 95-102 
    Details
    ISSN: 1432-0851
    Keywords: Key words Tumor necrosis factor gene ; Tumor-infiltrating lymphocytes ; Gene transduction ; Mechanisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We characterized tumor-infiltrating lymphocytes (TIL) from ascites of patients with ovarian or pancreatic cancer in which the human tumor necrosis factor (TNF) gene was successfully transduced with retrovirus vector. The TNF-gene-transduced TIL (TNF-TIL) from these patients showed a higher level of TNF production and higher cytotoxic activity against K562 and Daudi cells than did neomycin-phosphotransferase-gene-transduced TIL (neo-TIL). Of these TIL preparations, only that from pancreatic cancer was further characterized since it was collected in a relatively large amount. In spite of the fact that the autologous tumor cells showed resistance to soluble TNF, the TNF-TIL clearly demonstrated enhanced cytotoxicity against them as compared with neo-TIL. The enhanced cytotoxicity was ascribed to autocrine effects of secreted TNF on TIL, which included augmentation of adhesion molecule (CD2 and CD11a) and interleukin-2 receptor expression, and elevation of production of interferon γ, lymphotoxin and granulocyte/macrophage-colony-stimulating factor and its paracrine effect on target cells to facilitate them to be more susceptible to TIL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01520290
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production (1995)
    Springer
    Cancer immunology immunotherapy 40 (1995), S. 95-102 
    Details
    ISSN: 1432-0851
    Keywords: Tumor necrosis factor gene ; Tumor-infiltrating lymphocytes ; Gene transduction ; Mechanisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We characterized tumor-infiltrating lymphocytes (TIL) from ascites of patients with ovarian or pancreatic cancer in which the human tumor necrosis factor (TNF) gene was successfully transduced with retrovirus vector. The TNF-gene-transduced TIL (TNF-TIL) from these patients showed a higher level of TNF production and higher cytotoxic activity against K562 and Daudi cells than did neomycin-phosphotransferase-gene-transduced TIL (neo-TIL). Of these TIL preparations, only that from pancreatic cancer was further characterized since it was collected in a relatively large amount. In spite of the fact that the autologous tumor cells showed resistance to soluble TNF, the TNF-TIL clearly demonstrated enhanced cytotoxicity against them as compared with neo-TIL. The enhanced cytotoxicity was ascribed to autocrine effects of secreted TNF on TIL, which included augmentation of adhesion molecule (CD2 and CD11a) and interleukin-2 receptor expression, and elevation of production of interferon γ, lymphotoxin and granulocyte/macrophage-colonystimulating factor and its paracrine effect on target cells to facilitate them to be more susceptible to TIL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01520290
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  • 8
    Electronic Resource
    Electronic Resource
    Gastric Emptying in OLETF Rats Not Expressing CCK-A Receptor Gene (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 915-919 
    Details
    ISSN: 1573-2568
    Keywords: GASTRIC EMPTYING ; CCK-A RECEPTOR ; OLETF RAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have very recently demonstrated the lowacidity of gastric juice and the high susceptibility tothe development of gastric ulceration in OtsukaLong-Evans Tokushima Fatty (OLETF) rats not expressing CCK-A receptors. In the present study, gastricemptying in this strain was examined and compared withcontrol Long-Evans Tokushima Otsuka (LETO) rats. Gastricemptying was evaluated by the phenol red method. Gastric emptying 30 and 60 min after a liquidmeal in OLETF rats was significantly delayed compared tothat in control LETO rats. Intraperitoneal injection ofCCK-8 at a dose of 5 μg/kg significantly inhibited gastric emptying in control LETO rats, whereasthe same dose of CCK-8 failed to inhibit gastricemptying in OLETF rats. These results suggest for thefirst time that gastric emptying was suppressed in OLETF rats. We also confirmed with this mutant thatCCK delays gastric emptying through the CCK-Areceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018860313674
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  • 9
    Electronic Resource
    Electronic Resource
    Delayed Gastric Emptying by Helicobacter pylori Lipopolysaccharide in Conscious Rats (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 90-94 
    Details
    ISSN: 1573-2568
    Keywords: HELICOBACTER PYLORI ; LIPOPOLYSACCHARIDE ; GASTRIC EMPTYING
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was carried out to investigatethe possibility that lipopolysaccharide deprived fromHelicobacter pylori may alter gastric motility. Toaddress the question, we examined the effect of H. pylori lipopolysaccharide on gastricemptying in conscious rats. Gastric emptying wasevaluated by the phenol red method. Time-course anddose-related effects of intraperitoneal administrationof H. pylori lipopolysaccharide were investigated.Intraperitoneal injection of H. pylorilipopolysaccharide significantly suppressed gastricemptying of a liquid meal in a dose-dependent manner.The inhibitory action of H. pylori lipopolysaccharide wasobserved 2, 4, 8, or 12 hr after the injection. Theseresults suggest for the first time that H. pylorilipopolysaccharide may suppress gastric emptying in along-lasting fashion. It is also suggested that H. pylorimay influence gastric function through its cell wallstructure named lipopolysaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018828105226
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  • 10
    Electronic Resource
    Electronic Resource
    Intraduodenal lipid does not inhibit acid secretion in OLETF rats not expressing CCK-A receptor gene (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 2174-2179 
    Details
    ISSN: 1573-2568
    Keywords: gastric acid secretion ; CCK-A receptor ; OLETF rat ; lipid ; pylorus ligation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastric acid secretion in response to pylorus-ligation and duodenal fat feeding in Otsuka Long-Evans Tokushima Fatty (OLETF) rats without cholecystokinin-A receptor was examined. Acidity of gastric juice obtained from pylorus-ligated OLETF rats was significantly lower than that of control LETO rats. Gastric acid secretion in response to bethanechol, pentagastrin, or atropine was maintained in both OLETF and LETO rats. Intraduodenal lipid injection strongly inhibited gastric acid secretion in control LETO rats. In contrast, administration of lipid into the duodenum failed to inhibit acid secretion in OLETF rats. These results suggest that basal gastric acid secretion may be impaired in OLETF rats and that the cholecystokinin-A receptor is involved in lipid-induced acid inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02071397
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