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Inhibition of lipid peroxidation by diterpenoid fromPodocarpus nagi (1996)

Haraguchi, H. ; Ishikawa, H. ; Sakai, S. ; [et al.]

Springer

Cellular and molecular life sciences 52 (1996), S. 573-576

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ISSN: 1420-9071

Keywords: Podocarpus nagi ; totarol ; lipid peroxidation ; oxidative stress

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract A diterpenoid, totarol (1), fromPodocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone isolated from the same source, had no antioxidative activity. Furthermore, totarol protected red cells against oxidative hemolysis. This diterpene was shown to be effective in protecting biological systems against oxidative stresses.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01969731

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