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  • 1
    Electronic Resource
    Electronic Resource
    Effects of recombinant interleukin-1β on decorin gene expression in human periodontal ligament fibroblast and its possible transcriptional regulation (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 32 (1997), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-1 β (IL-1β) is a potent regulator of osteoprogenitor cells and fibroblasts, and is believed to be responsible for the bone loss and connective tissue breakdown that occurs in periodontitis. Decorin, a major small proteoglycan in the periodontium, has been shown as an important mediator of the organization of the pericellular and extracellular matrix. Since the HPLF play a significant role in the regulation of extracellular matrix metabolism, it was important to clarify the causal relationship between cytokines, HPLF and proteoglycans. We investigated the effect of IL-1β on decorin gene expression and its functional regulation to elucidate the intracellular mechanism mediating the action of IL-1β. Quiescently confluent HPLF cultures were incubated for different treatment periods with various concentrations of IL-1β and/or 10-4 M cycloheximide (Cx) in culture medium supplemented with 1% charcoal-stripped serum for different treatment periods. Northern hybridization analyses, using decorin cDNA probe, showed that IL-1β increased the abundance of decorin mRNA in both a dose- and time-dependent manner. Most of the stimulation was blocked by Cx, indicating that the regulation of decorin gene expression by IL-1β may be via an indirect pathway, requiring new protein synthesis which regulates the promoter. Gel mobility shift analyses detected the specific DNA binding activity of a nuclear extract of AP-1, but not NF-κB, that could bind to the recognition site of decorin gene promoter fragments with the increased abundance in IL-1β treatment groups. These results suggest that the increased transcription of decorin gene by HPLF in the presence of IL-1β is mediated at least in part through the interaction of AP-1 with the decorin gene promoter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1997.tb00528.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of frequency on the fatigue behavior of [±45]4s laminate of carbon fiber reinforced polyetheretherketone (PEEK) composites under tension-tension loading (1995)
    Springer
    Journal of polymer research 2 (1995), S. 171-178 
    Details
    ISSN: 1572-8935
    Keywords: Fatigue behavior ; AS-4/PEEK ; Composites ; Weibull distribution function ; Tension-tension ; Surface temperature change
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Fatigue behavior of carbon fiber reinforced poly etheretherketone (PEEK) laminated composite was investigated. The [±45]4s AS-4/PEEK laminated composites under static tensile measurement at various test temperatures were conducted. Three tension-tension fatigue loading frequencies, 1 Hz, 5 Hz and 10 Hz, were selected to study the effect of frequency on the fatigue behavior of [±45]4s AS-4/PEEK laminate. The survival probability of experimental fatigue life data under different stress amplitude tests were estimated and analyzed by the median rank order-statistic cumulative-distribution function and the Weibull distribution function. The S-N curves at different fatigue loading frequencies exhibited a trend of two-segment straight line curves. The increase in surface temperature of specimens was found and the thermal stress history was also investigated by thermo-image techniques during fatigue life testing. The fatigue failure mechanism was investigated by X-ray radiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01494253
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  • 3
    Electronic Resource
    Electronic Resource
    Gaseous Aliphatic Aldehydes in Smoke from Burning Raw Materials of Chinese Joss Sticks (1996)
    Springer
    Bulletin of environmental contamination and toxicology 57 (1996), S. 361 -366 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900199
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  • 4
    Electronic Resource
    Electronic Resource
    Mutagenic Activity of Incense Smoke in Comparison to Formaldehyde and Acetaldehyde in Salmonella typhimurium TA102 (1997)
    Springer
    Bulletin of environmental contamination and toxicology 58 (1997), S. 394 -401 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900347
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  • 5
    Electronic Resource
    Electronic Resource
    Vapor Phase and Particulate Bound Polycyclic Aromatic Hydrocarbons in the Smoke of Mosquito Coils (1997)
    Springer
    Bulletin of environmental contamination and toxicology 59 (1997), S. 868-874 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900562
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  • 6
    Electronic Resource
    Electronic Resource
    Capillary electrochromatographic separation of amino acid enantiomers with molecularly imprinted polymers as chiral recognition agents (1997)
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 130-132 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The use of molecularly imprinted polymers polymerized in a capillary for the separation of amino acid enantiomers by electrochromatography is described. The substrate-selective polymers were prepared by using l-phenylalanine anilide as print molecule and methacrylic acid as the functional monomer. The treatment of the inside surface of the capillary, the composition of the polymer and the electrochromatographic running conditions were investigated. This preliminary report demonstrated a novel and simple method for capillary electrochromatographic separations of amino acid enantiomers using molecularly imprinted polymers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050126
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  • 7
    Electronic Resource
    Electronic Resource
    Combined chiral crown ether and β-cyclodextrin for the separation ofo-, m-, andp-fluoro-D,L-phenylalanine by capillary gel electrophoresis (1996)
    Springer
    Chromatographia 42 (1996), S. 559-565 
    Details
    ISSN: 1612-1112
    Keywords: Capillary gel electrophoresis (CGE) ; Chiral separation ; Fluorophenylalanine ; 18-Crown-6-tetracarboxylic acid ; β-Cyclodextrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A combination of (β-CD) with a chiral crown ether, 18-crown-6-tetracarboxylic acid (18C6TA), has been used for the chiral capillary gel electrophoretic (CGE) separation of the six enantiomers and positional isomers in a mixture ofo-, m-, andp-fluoro-D,L-phenylalanine; the isomers were successfully resolved in 0.3% agarose −2×10−2 mol L−1 18C6TA −2×10−2 mol L−1 β-CD. The method has also been successfully extended to the separation of the enantiomers of 13 other amino acid or primary amine substrates. The role of the chiral crown ether was studied. The effects of the concentrations of 18C6TA, β-CD and agarose, and of pH and applied field strength on the migration time and separation factors of the analytes are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290292
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  • 8
    Electronic Resource
    Electronic Resource
    Molecularly imprinted polymer as chiral selector for enantioseparation of amino acids by capillary gel electrophoresis (1996)
    Springer
    Chromatographia 43 (1996), S. 585-591 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Molecularly imprinted polymer ; Enantioseparation ; Amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A capillary electrophoresis method for the enantioseparation of D,L-aromatic amino acids using molecularly imprinted polymer as chiral selector has been developed. Methacrylic acid was used as functional monomer and ethylene glycol dimethacrylate (EDMA) as crosslinking monomer. The molecularly imprinted polymer was packed in capillaries by incorporating with acrylamide gel. The composition of the polymerization mixtures affects the separation factor to some extent. The molar ratio of cross-linker to functional monomer to print molecule was 20∶4∶1, which gives the best separation for aromatic amino acid enantiomers by using L-phenylalanine anilide (L-pheAN) as print molecule. Under the same conditions, however, separation of D,L-phenylalanine using L-phenylalanine as print molecule is poorer than that using L-pheAN. Polymer particles (≤5 μm) were supported by 6% acrylamide and 5% bisacrylamide gel in the capillary. The effects of organic solvents, electrophoretic buffer and pH on separation were also investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02292972
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  • 9
    Electronic Resource
    Electronic Resource
    Enantiomeric resolution of dansyl amino acids by capillary electrochromatography based on molecular imprinting method (1998)
    Springer
    Chromatographia 47 (1998), S. 625-629 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrochromatography ; Enantioseparation ; Molecular imprinting ; Dansyl amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Recognition sites incorporating both pyridinyl and carboxy functionalities prepared by molecular imprinting were used for the enantioseparation of dansylated amino acids by capillary electrochromatography (CEC). Simultaneous non-covalent molecular imprinting of two chemically distinct functional monomers, vinylpyridine and methacrylic acid, was demonstrated in ethylene glycol dimethacrylate-based copolymers. Polymers obtained were ground and sieved to particles 〈10 μm for filling into capillaries for CEC. Such imprinted polymers demonstrated improved recognition capabilities compared to polymers incorporating only one of the functional monomers. Several aspects of polymer preparation were investigated including the polymerization temperature, effect of solvent, composition of polymer together with the running conditions of the CEC. Separation was highly-specific and depended on the presence of both print molecule and functional monomers in the polymerization mixture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467444
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  • 10
    Electronic Resource
    Electronic Resource
    Simultaneous separation of sixteen positional and optical isomers of the tryptophan family by ligand-exchange micellar electrokinetic chromatography (1999)
    Springer
    Chromatographia 49 (1999), S. 436-443 
    Details
    ISSN: 1612-1112
    Keywords: Micellar electrokinetic chromatography ; Chiral separation ; Positional and optical isomers ; Ligand exchange ; Tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Ligand-exchange micellar electrokinetic chromatography has been used for the simultaneous separation of 16 positional and optical isomers of the tryptophan family. The Cu(II) complex with L-hydroxyproline was used as the chiral selector. Two groups of anionic surfactant, linear alkylbenzenesulfonates (LAS) and straight-chain alkyl sulfates such as sodiumn-decyl sulfate (SDeS), sodium dodecyl sulfate (SDS) and sodiumn-tetradecyl sulfate (STS), were used for simultaneous separation. The best result was obtained by use of SDS. The influence of SDS concentration and of pH on the separation was investigated. The separation behavior in the absence of the Cu(II) complex with L-hydroxyproline was also examined. Use of organic modifiers causes the resolution to decrease. Relationships between the logarithm of the octanol-water partition coefficient (logP OW) and resolution, and between logP OW and migration time are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467620
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