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  • 1995-1999  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Regulation of G Protein-Coupled Receptor Kinase 2 in Brains of Opiate-Treated Rats and Human Opiate Addicts (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 70 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of opiate drugs (heroin, morphine, and methadone) on the levels of G protein-coupled receptor kinase 2 (GRK2) were studied in rat and human brain frontal cortices. The density of brain GRK2 was measured by immunoblot assays in acute and chronic opiate-treated rats as well as in opiate-dependent rats after spontaneous or naloxone-precipitated withdrawal and in human opiate addicts who had died of an opiate overdose. In postmortem brains from human addicts, total GRK2 immunoreactivity was not changed significantly, but the level of the membrane-associated kinase was modestly but significantly increased (12%) compared with matched controls. In rats treated chronically with morphine or methadone modest increases of the enzyme levels (only significant after methadone) were observed. Acute treatments with morphine and methadone induced dose- and time-dependent increases (8–22%) in total GRK2 concentrations [higher increases were observed for the membrane-associated enzyme (46%)]. Spontaneous and naloxone-precipitated withdrawal after chronic morphine or methadone induced a marked up-regulation in the levels of total GRK2 in the rat frontal cortex (18–25%). These results suggest that GRK2 is involved in the short-term regulation of μ-opioid receptors in vivo and that the activity of this regulatory kinase in brain could have a relevant role in opiate tolerance, dependence, and withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.70031249.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The 21st Century: a better world or a brave new world (1999)
    Cambridge : Emerald
    Foresight 1 (1999), S. 389-391 
    Details
    ISSN: 1465-9832
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Political Science
    Notes: Based on the world report, The World Ahead: our Future in the Making, this article identifies four major challenges which we face at the dawn of the 21st century: peace, social inequality, sustainable development and long-term global planning. It argues that society needs to be rebuilt and envisages it as an international democracy founded on four pillars or contracts - social, natural, cultural and ethical - and looks at some of the preconditions and costs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/14636689910802287
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Obituary Eladio Viñuela (1937-99) (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 400 (1999), S. 822-822 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ... Eladio Viñuela, who died earlier this year in Madrid at the age of 62, was one of Spain's leading scientists. Beyond his own substantial research contributions, he was an inspiration to the Spanish scientific community, which has lost a key player in developing the country's strength in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/23599
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    Paper (German National Licenses)
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