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  • 1995-1999  (5)
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  • 1
    Digitale Medien
    Digitale Medien
    Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The distribution of mast cells (MCs) containing tryptase (T) and chymase (C) was studied in the non-lesional and lesional skin of 26 patients with atopic dertnatitis (AD) and 23 patients with non-atopic nummular eczema (NE). and in the skin of eight healthy controls. T and C activities were demonstrated enzymehistochemically using 2-Gly-Pro-Arg-MNA and Suc-Val-Pro-Phe-MNA as substrates, respectively. The T- and C-containing MCs were counted separately in the epidermis, in contact with the basement membrane. In the papillary dermis and in different dermal levels (0·2 mm each). Also, the C protein was determined immunohistochemically. T-positive MCs were similarly distributed in non-lesional and lesional skin of both AD and NE. The MC number was relatively high in the upper dermis (papillary dermis and levels I and I!) of non-lesional and lesional skin of AD. In the upper dermis of non-lesional AD and NE skin and in normal skin, about 50% of T-positive MCs displayed C activity, whereas the percentage in lesional AD and NE skin was only about 30%. hi this respect, the non-lesional and lesional samples differed significantly froLu each other in both dennatoses (in AD p = 0%005, in NEP = 0·002. Students' t-test). In all samples the MC number decreased in the deeper dermal levels, although numerous T-containing MCs were still counted in the deeper dermis (dermal levels IV-VII) of lesional AD and NE skiti. differing significantly from the MC number in normal skin (In ADp = 0·005. in NE p=0·041). In the deeper dermis. the percentage of MCs containing active C was about 70% in non-lesional and lesional AD and NE. and about 90% in normal healthy skin. However, in the upper dermis of non-lesional and lesional skin of both AD and NE. about H()% of all MCs contained the C protein, which differed significantly from the value of 100% in normal skin (p〈0·5). In conclusion, the increased number of T-positive MCs in the upper dermis of non-lesional and lesional AD contributes to promoting inflammation. C apparently loses its activity in the upper dermis of lesional AD and especially in NE. Thus. Ihe enzyme partially lacks its capability to suppress inflammation, such as degradation of neuropeptides and proteins. The dysregulation of these proteinases exists already in non-lesional skin of AD and NE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.01831.x
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  • 2
    Digitale Medien
    Digitale Medien
    Histamine release in skin monitored with the microdialysis technique does not correlate with the weal size induced by cow allergen (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary The purpose of this study was to monitor histamine release in immediate-type hypersensitivity reactions in the skin of 10 atopic patients, sensitive to cow, by using the microdialysis technique. Three healthy subjects, without any atopic features or background, served as the control group. The probe inserted into the forearm dermal skin was perfused with isotonic saline solution. Samples were collected at 15-min intervals. After the first allergen challenge of four prick tests close to the probe with cow allergen extract, the skin was similarly repricked again in five patients and three healthy subjects, and in five other patients, 25μl of 10μmol/l substance P (SP) was injected intracutaneously. The samples were analysed for histamine by radioenzyme assay. The patients were clinically evaluated for allergic symptoms, prick- and scratch-patch test reactivity and for serum cow-specific, and total, IgE levels.The baseline histamine concentration was 7·5±4·0 nmol/l (mean±standard deviation: SD; n=10). After the allergen challenge, the histamine concentration in the consecutive samples was 11·9±11·0 nmol/l, 91·1±127·3 nmol/l, 61·0±94·2 nmol/l and 33·7±53·7 nmol/l. The peak concentration was detected in the 15–30 min fraction, and it varied between 0 and 406 nmol/l regardless of the weal size. The second allergen challenge was unable to induce marked additional histamine release, but SP induced extensive histamine liberation in those patients who did not exhibit histamine release during the preceding prick tests. In three healthy subjects, the baseline histamine concentration was 6·2±3·9 nmol/l. After the allergen challenge, no additional histamine liberation could be measured.Surprisingly, the histamine release was not related to the size of the cow-induced weal nor was it related to any specific allergic symptoms or IgE levels. The results suggest that, in some patients, mast cell mediators other than histamine play a significant part in immediate-type allergic reactions of skin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-744.x
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  • 3
    Digitale Medien
    Digitale Medien
    Changing trends in the incidence of non-Hodgkin's lymphoma in Europe (1997)
    Springer
    Annals of oncology 8 (1997), S. 49-54 
    Details
    ISSN: 1569-8041
    Schlagwort(e): changing incidence ; epidemiology ; NHL ; population-based registries ; REAL
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Non-Hodgkin's lymphoma (NHL) is not a uniform disease entity, and inorder to investigate the reported changes in incidence we have set up astudy in seven population-based cancer registries in Europe. The study isdesigned to look at changes in the incidence of total NHL and diseasesubgroups using standard definitions and methodology. The registries arebased in Leeds, Dijon, Kuopio, Odense, Florence, Eindhoven, and Ragussa. Theclassification system we have used is based on the REAL classification andhas utility for epidemiological studies. We have used it to convert datasets which have utilized both local cases and the ICD-O classification. Inorder to improve data reproducibility, CLL/LL, myeloma/MGUS, lymphoblasticdisease, and Hodgkin's disease have been excluded because of the difficultyin defining incident cases accurately. The preliminary results of this studyshow that there is still an upward trend in incidence rate and that inYorkshire this is 3% per annum in total NHL. The subgroups which areincreasing are extranodal and nodal peripheral T-cell lymphoma. Similarincreases in incidence have been reported for the other registries. Weconclude that there is a continued upward trend in incidence of NHL, thecauses of which are uncertain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008269930158
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  • 4
    Digitale Medien
    Digitale Medien
    Changing trends in the incidence of non-Hodgkin's lymphoma in Europe (1997)
    Springer
    Annals of oncology 8 (1997), S. 49-54 
    Details
    ISSN: 1569-8041
    Schlagwort(e): changing incidence ; epidemiology ; NHL ; population-based registries ; REAL
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Non-Hodgkin's lymphoma (NHL) is not a uniform disease entity, and in order to investigate the reported changes in incidence we have set up a study in seven population-based cancer registries in Europe. The study is designed to look at changes in the incidence of total NHL and disease subgroups using standard definitions and methodology. The registries are based in Leeds, Dijon, Kuopio, Odense, Florence, Eindhoven, and Ragussa. The classification system we have used is based on the REAL classification and has utility for epidemiological studies. We have used it to convert datasets which have utilized both local cases and the ICD-O classification. In order to improve data reproducibility, CLL/LL, myeloma/MGUS, lymphoblastic disease, and Hodgkin's disease have been excluded because of the difficulty in defining incident cases accurately. The preliminary results of this study show that there is still an upward trend in incidence rate and that in Yorkshire this is 3% per annum in total NHL. The subgroups which are increasing are extranodal and nodal peripheral T-cell lymphoma. Similar increases in incidence have been reported for the other registries. We conclude that there is a continued upward trend in incidence of NHL, the causes of which are uncertain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008269930158
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  • 5
    Digitale Medien
    Digitale Medien
    Characteristics of poly(L-)lactic acid suture applied to fascial closure in rats (1996)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 30 (1996), S. 187-192 
    Details
    ISSN: 0021-9304
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin , Technik allgemein
    Notizen: A new poly(L-)lactic acid (PLLA) thread was tested by applying it in fascial closures of male Wistar rats. The tissue reactions around the thread and in the fascial union, and the changes on the surface and the mechanical properties of the thread were evaluated at 1, 3, 6, 12, 28, and 52 weeks following surgery. Histologically, the extension of the general inflammatory reaction and the number of the different cell types did not markedly change during the 52-week follow-up period. The surface of the thread was intact up to 28 weeks when examined with the scanning electron microscope. At 52 weeks no thread was found. The breaking force and the stretching of the incubated PLLA thread was reduced about 20% during the first 2 weeks and it remained constant up to 6 weeks. The in vivo testing of the fascial strips closed with the PLLA thread retained their resistance against the breaking force, nearly comparable to that of the intact control fascial strips. It can be concluded that the PLLA thread is a suitable suture for wounds that require healing time of up to 28 weeks and thus need good support from the suture. © 1996 John Wiley & Sons, Inc.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
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