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  • 1
    Electronic Resource
    Electronic Resource
    Membrane-Bound c-Type Cytochromes in Heliobacillus mobilis. In Vivo Study of the Hemes Involved in Electron Donation to the Photosynthetic Reaction Center (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 11831-11839 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00037a022
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  • 2
    Electronic Resource
    Electronic Resource
    Contrasting patterns of brain activity in anxious apprehension and anxious arousal (1999)
    Oxford, UK : Blackwell Publishing
    Psychophysiology 36 (1999), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Evidence suggests that a distinction between anxious apprehension (worry) and anxious arousal (somatic anxiety) might account for some discrepancies in the literature examining brain activity in anxiety. In the current study, we compared the regional brain activity of groups of anxious apprehension and anxious arousal participants, selected on the basis of self-report measures previously shown to be psychometrically distinct from each other and from a specific measure of depression. Patterns of hemispheric asymmetry in electroencephalogram alpha distinguished the two types of anxiety, with the anxious arousal group showing more right than left activity. No significant asymmetry was found for the anxious apprehension group. The results provide further support for contrasting patterns of brain activity in distinct types of anxiety. Research is needed to specify further the topography and functional significance of this distinction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1469-8986.3650628
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  • 3
    Electronic Resource
    Electronic Resource
    On Bénard–Marangoni instability in the presence of a magnetic field (1995)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 7 (1995), S. 1176-1178 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Explicit asymptotic expressions are derived for the first unstable mode of surface tension driven instability in an electrically conducting fluid subjected to a strong magnetic field. The spatial structure of the velocity, temperature, and electric current density is characterized in terms of Hartmann boundary layers—a concept that permits a physical explanation of the role of the magnetic field and an understanding of scaling laws derived in previous work. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.868562
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  • 4
    Electronic Resource
    Electronic Resource
    Somatotopy in the Human Motor Cortex Hand Area. A High-Resolution Functional MRI Study (1997)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 9 (1997), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fine-scale somatotopic encoding in brain areas devoted to sensorimotor processing has recently been questioned by functional neuroimaging studies which suggested its absence within the hand area of the human primary motor cortex. We re-examined this issue by addressing somatotopy both in terms of functional segregation and of cortical response preference using oxygenation-sensitive magnetic resonance imaging at high spatial resolution. In a first step, spatial representations of self-paced isolated finger movements were mapped by using motor rest as a control state. A subsequent experimental design studied the predominance of individual finger movements by using contrasting finger movements as the control task. While the first approach confirmed previous reports of extensive overlap in spatial representations, the second approach revealed foci of differential activation which displayed an orderly mediolateral progression in accordance with the classical cortical motor homunculus. We conclude that somatotopy within the hand area of the primary motor cortex does not present as qualitative functional segregation but as quantitative predominance of certain movement or digit representation embedded in an overall joint hand area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1997.tb01384.x
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  • 5
    Electronic Resource
    Electronic Resource
    Managing the linkage with primary producers: experiences in the Australian grain industry (1997)
    Bingley : Emerald
    Supply chain management 2 (1997), S. 4-6 
    Details
    ISSN: 1359-8546
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Considers the challenge facing an agricultural co-operative operating in a commodity market but seeking ways of adding value both to the output of its members and to the services it offers to its members and its customers. Highlights the importance of trust and the value of developing close working relationships over time, in order to communicate the need for radical change in strategic focus and implement an effective change management programme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/13598549710156295
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  • 6
    Electronic Resource
    Electronic Resource
    MECHANISMS FOR PRESERVED CEREBROVASCULAR AUTOREGULATION DURING HYPERTENSION IN RATS AFTER SINOAORTIC DENERVATION (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Cerebral blood flow (CBF) and cerebrovascular resistance (CVR) autoregulate to higher levels of arterial pressure (AP) in rats after sinoaortic denervation (SAD) than in intact rats.2. Potential mechanisms for this phenomenon were studied by monitoring CBF by laser flowmetry while increasing AP in rats after: (i) SAD; (ii) SAD plus bilateral removal of the superior cervical ganglia; (iii) SAD plus interruption of all renal vessels and nerves (renal isolation); (iv) SAD plus sympathectomy and renal isolation; and (v) intravenous treatment with the nitric oxide synthase inhibitor L-nitroarginine (LNA).3. Compared to intact control rats autoregulation persisted to higher absolute levels of AP in SAD rats with isolation of the kidneys and resistance did not fall significantly below that in rats with SAD alone.4. Effects of SAD on autoregulation were not altered by combining renal isolation with an interruption of sympathetics.5. LNA did not affect the baroreflex but blocked a breakthrough of autoregulation even at a maximal mean AP (MAP) of 189 ± 2mmHg.6. Breakthrough occurred in animals pretreated with LNA plus L-arginine but not in animals given LNA plus D-arginine.7. These data are consistent with a role of the baroreflex in the expression of breakthrough and suggest that breakthrough may result from release of nitric oxide or a nitric oxide donor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02978.x
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  • 7
    Electronic Resource
    Electronic Resource
    Indigo: a World-Wide-Web review of genomes and gene functions (1998)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology reviews 22 (1998), S. 0 
    Details
    ISSN: 1574-6976
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The present article describes a genome database reviewing gene-related knowledge of two model bacteria, Bacillus subtilis and Escherichia coli. The database, Indigo, is open through the World-Wide Web (). The concept used for organising the data, the concept of neighbourhood, allows one to explore the database content in an efficient although somewhat unusual way. Here, genes are related to each other by a variety of neighbourhoods, including proximity in the chromosome, phylogenetic kinship, participation in a common metabolic pathway, common presence in an article of the literature, or similar use of the genetic code. Several examples illustrate how this concept of neighbourhood permits one to review the available knowledge about a given gene or gene family, and elaborate unexpected, but revealing, analyses about gene functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6976.1998.tb00368.x
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  • 8
    Electronic Resource
    Electronic Resource
    Comrie, B., Stone, G., Polinsky, M.: The Russian Language in the Twentieth Century, Oxford 1996 (1999)
    Springer
    Russian linguistics 23 (1999), S. 257-263 
    Details
    ISSN: 1572-8714
    Source: Springer Online Journal Archives 1860-2000
    Topics: Slavonic Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006893305650
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  • 9
    Electronic Resource
    Electronic Resource
    8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) acts as a muscarinic receptor antagonist in the epithelial cell line HT29 (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 295-301 
    Details
    ISSN: 1432-1912
    Keywords: Key words TMB-8 ; Fura-2 ; HT29 ; M3-receptor ; ATP ; Carbachol ; Neurotensin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  8-(N, N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) is a widely used pharmacological tool to investigate the involvement of intracellular Ca2+ stores in cellular responses. In this study we investigate the effect of TMB-8 as a putative inhibitor of “Ca2+ signalling” in single fura-2 loaded HT29 colonic epithelial cells stimulated by ATP, carbachol (CCH) and neurotensin (NT). TMB-8 effectively inhibited the CCH-induced (100 μmol/l intracellular Ca2+ ([Ca2+]i) transient with an IC50 of 20 μmol/l. However, [Ca2+]i transients induced by other phospholipase C coupled agonists ATP (10 μmol/l, n=4) and NT (10 nmol/l, n=4) remained unaffected by TMB-8 (50 μmol/l). The agonist-induced [Ca2+]i transients remained equally unaffected by 100 μmol/l TMB-8 when the stimulatory concentration was reduced to 0.5 μmol/l for ATP (n=4) or 1 nmol/l for NT (n=4). The competitive nature of the TMB-8-induced inhibition of the CCH-induced [Ca2+]i transient was demonstrated by examining the agonist at various concentrations in absence and presence of the antagonist. High TMB-8 concentrations (100 μmol/l) alone induced a small [Ca2+]i increase (Δ[Ca2+]i: 40±5 nmol/l, n=7). We assume that this increase is a consequence of a TMB-8 induced intracellular alkalinization (ΔpH: 0.1±0.02, n=7) occurring simultaneously with the increase in [Ca2+]i. From these results we draw the following conclusions: (1) In sharp contrast to a large number of other studies, but in agreement with studies in other types of cells, these results substantially challenge the value of the “tool” TMB-8 as an “intracellular Ca2+ antagonist”; (2) TMB-8 acts a muscarinic receptor antagonist at the M3 receptor; (3) TMB-8 does not influence the release of Ca2+ from intracellular stores when IP3 signal transduction is activated by ATP or NT; (4) TMB-8 as a weak organic base alkalinizes the cytosol at high concentrations; and (5) TMB-8 induces small [Ca2+]i transients at higher concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168631
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  • 10
    Electronic Resource
    Electronic Resource
    8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) acts as a muscarinic receptor antagonist in the epithelial cell line HT29 (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 295-301 
    Details
    ISSN: 1432-1912
    Keywords: TMB-8 ; Fura-2 ; HT29 ; M3-receptor ; ATP ; Carbachol ; Neurotensin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 8-(N, N-diethyl amino) octyl-3,4,5-trimethoxybenzoate (TMB-8) is a widely used pharmacological tool to investigate the involvement of intracellular Ca2+ stores in cellular responses. In this study we investigate the effect of TMB-8 as a putative inhibitor of “Ca2+ signalling” in single fura-2 loaded HT29 coIonic epithelial cells stimulated by ATP, carbachol (CCH) and neurotensin (NT). TMB-8 effectively inhibited the CCH-induced (100 μmol/l intracellular Ca2+ ([Ca2+]i) transient with an IC50 of 20 μmol/l. However, [Ca2+]i transients induced by other phospholipase C coupled agonists ATP (10 μmol/l, n = 4) and NT (10 nmol/l, n = 4) remained unaffected by TMB-8 (50 μmol/l). The agonist-induced [Ca2+]i transients remained equally unaffected by 100 μmol/l TMB-8 when the stimulatory concentration was reduced to 0.5 μmol/I for ATP (n = 4) or 1 nmol/l for NT (n = 4). The competitive nature of the TMB-8-induced inhibition of the CCH-induced [Ca2+]i transient was demonstrated by examining the agonist at various concentrations in absence and presence of the antagonist. High TMB-8 concentrations (100 μmol/l) alone induced a small [Ca2+]i increase (Δ[Ca2+]i: 40 ± 5 nmol/l, n = 7). We assume that this increase is a consequence of a TMB-8 induced intracellular alkalinization (Δ pH: 0.1 ± 0.02, n = 7) occurring simultaneously with the increase in [Ca +]i. From these results we draw the following conclusions: (1) In sharp contrast to a large number of other studies, but in agreement with studies in other types of cells, these results substantially challenge the value of the “tool” TMB-8 as an “intracellular Ca2+ antagonist”; (2) TMB-8 acts a muscarinic receptor antagonist at the M3 receptor; (3) TMB-8 does not influence the release of Ca2+ from intracellular stores when IP3 signal transduction is activated by ATP or NT; (4) TMB-8 as a weak organic base alkalinizes the cytosol at high concentrations; and (5) TMB-8 induces small [Ca2+]i transients at higher concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168631
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    Paper (German National Licenses)
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