ISSN:
1432-0428
Keywords:
Key words Exocytosis
;
syntaxin
;
pancreatic beta cell
;
secretion
;
SNAP receptor.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit Ca2+-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules. [Diabetologia (1995) 38: 860–863]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001250050364
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