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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Child & family social work 2 (1997), S. 0 
    ISSN: 1365-2206
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology
    Notes: The link between child care and mental health problems in social work clients has begun to attract some attention. Despite some review articles, research is, as yet, at a very early stage of development. Maternal depression and child care problems in particular appear likely to be closely associated. This paper focuses on the link between maternal depression and the most severe of child care problems: child abuse. The paper shows a significant relationship between maternal depression and child abuse. It explores this relationship by distinguishing three groups: families where no abuse had occurred (non abuse families), families where abuse had occurred but where the mother was not depressed (non depressed-abuse group) and families where both child abuse and maternal depression were present (depressed-abuse group). The depressed-abuse group are shown to be considerably worse off than both the other groups for a range of measures, including indices of deprivation and range and severity of social problems. The depressed-abuse group were also more chronic users of services and consumed far more resources than the other two groups. Remarkably, there were few differences between the non abuse group and the non depressed abuse group in nature and severity of problems and intervention. Depression in mothers, then, provides the major distinction between families where abuse was an issue compared with families where abuse was not present. Such families are characterized not simply by maternal depression and child abuse, but frequently by abuse of the mother herself, who is often socially isolated. These findings are of major importance for child care practice, indicating that working with the mother’s depression and the social conditions that provide its backdrop, are a major aspect of social work practice.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 26 (1997), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The primary health care setting has been established as a key venue for identifying and working with depression. Despite this, and the high risk of depression experienced by women in the postnatal period, maternal depression has been little examined in the work of health visitors. Furthermore, although research has been undertaken on social factors related to depression in the general population, there is nothing specifically on the population of health visitor clients. This study focuses on social and demographic factors related to maternal depression amongst users of health visitor services. In a study of 701 women in rural and urban areas, maternal depression was found to be significantly associated with the absence of receipt of further or higher education, housing status, employment status, reliance on state benefit, family size, family breakdown (reconstituted families and single divorced or separated women), perceptions of support and difficulty in getting children off to sleep, particularly after the first year of the child's life. Loglinear analysis was used to identify the most parsimonious model of these relationships, and three key areas emerged: social and economic disadvantage, family size and history of family disruption. The model suggested that ‘behind’ these data may have been poor life chances, as evidenced by data on further and higher education. These data identify elements of objective life circumstances important for depression in this group. They have considerable significance for the organization of health service resources and these are discussed.
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    London : Periodicals Archive Online (PAO)
    The British journal of social work. 25:3 (1995:June) 265 
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  • 4
    ISSN: 1573-7403
    Keywords: estrogen receptor ; pituitary adenoma ; RT-PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Estrogen (E2), acting via its nuclear receptors, has been implicated in tumor development and growth, particularly in the pathogenesis of breast cancer. E2 also modulates anterior pituitary hormone production and is a potent cell mitogen. Until recently, the actions of E2 were thought to be mediated by a single estrogen receptor (ER) isoform (ERα), and currently little is known of the pathophysiological relevance of the ERβ isoform. The presence of ERβ mRNA has been demonstrated by RT-PCR in the normal human pituitary, although expression of ERβ mRNA in human pituitary tumors has not been described. We have used semiquantitative RT-PCR to determine the relative levels of expression of ERβ mRNA in normal human pituitaries, non-functioning pituitary adenomas and GH-secreting tumors. ERβ mRNA was detected in normal pituitaries and all pituitary tumors examined. The ratio of ERβ mRNA to β-actin mRNA expression was significantly reduced in non-functioning pituitary tumors (NFTs; 0.92 ± 0.09; mean ± SE; n=23) compared with findings in normal pituitaries (1.56 ± 0.21; mean ± SE; n=5; p〈0.05 Student's t-test). Studies of ERβ protein expression are required to determine the functional significance of reduced ERβ mRNA expression in NFTs.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Virus genes 14 (1997), S. 245-249 
    ISSN: 1572-994X
    Keywords: pre-terminal protein ; avian adenovirus ; amino acid sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nucleotide sequence of the genomic region between map units 25 and 31 of the fowl adenovirus serotype 10 (FAV10) was determined and analyzed. An open reading frame (ORF) running from right to left (that is on l-strand) of 1806 nucleotides in length was found. This ORF encoded a polypeptide of 602 amino acids with a molecular weight (Mr) of approximately 70.4 kilo-Daltons. The genomic location of the ORF was determined to be between map units 25.5 and 29.5, similar to the genomic position of the human adenovirus (HAV) terminal protein precursor (pTP). From its size, approximate genomic location and direction of transcription, this ORF was suspected to be the FAV10 homologue of the pTP. Amino acid sequence comparison with the HAV2 pTP revealed an amino acid sequence similarity of 32.4% but was 51 amino acids shorter in length. A potential proteolytic cleavage site was identified which would create a post-cleavage terminal protein of 316 amino acids, again comparable to the 322 amino acids of the post-cleavage TP of HAV.
    Type of Medium: Electronic Resource
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