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  • 1
    Electronic Resource
    Electronic Resource
    Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats (1998)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1998), S. 620-624 
    Details
    ISSN: 1432-1912
    Keywords: Key words Antiandrogen ; Tyrosine hydroxylase ; Catecholamine ; SHR; inbred ; Adrenal medulla ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effects of the antiandrogen flutamide on the activity of tyrosine hydroxylase, the levels of its encoding mRNA, and catecholamine levels in the adrenal medulla of male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flutamide (30 mg/kg) was administered subcutaneously daily (between 9 and 15 weeks of age). The systolic blood pressure of flutamide-treated SHR rats was lower than that of control SHR. Epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and the levels of encoding mRNA in the adrenal medulla were significantly lower in flutamide-treated SHR rats than in paired controls. Systolic blood pressure, epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and encoding mRNA in the adrenal medulla of WKY rats showed no significant differences between flutamide-treated and control groups. These findings suggested that flutamide may have cardiovascular effects through alteration of the catecholamine synthetic pathway caused by removal of androgen receptor stimulation on the expression of tyrosine hydroxylase in the adrenal medulla of male SHR rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005216
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  • 2
    Electronic Resource
    Electronic Resource
    Polymerizable tautomers, 11Part 10: cf. ref. 1. Tautomerism and polymerization of p-vinylbenzoylacetone (1995)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 196 (1995), S. 621-628 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Solvent effects on tautomerism and polymerization of p-vinylbenzoylacetone (1) were studied. 1 exhibits the coexistence of the ketonic and enolic forms (the latter is pedominant), and the tautomeric equilibria shift with the solvents. Multiparametric regression analysis of the tautomeric constants reveals that the equilibria depend on polarity and hydrogen bond donor acidity of the solvents. On the other hand, the polymerization of 1 is not affected by the solvents. The polymerization of 1 conforms to the conventional model (rule of square root). Monomer reactivity ratios r1 = 2,56 and r2 = 0,32 were obtained in the copolymerization of 1 (M1) and styrene (M2) in benzene.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1995.021960217
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction between drugs and water-soluble polymers: VIII. Binding position of naproxen to bovine serum albumin (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Biospectroscopy 1 (1995), S. 105-111 
    Details
    ISSN: 1075-4261
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The interaction between naproxen (NP) and bovine serum albumin (BSA) was investigated by equilibrium dialysis. Since the binding constant of NP to BSA was independent of ionic strength and decreased with increase of alkyl chain length of fatty acid added, the interaction between NP and BSA was considered to be due to hydrophobic mechanism. Chemical shifts in 1H-NMR spectra of NP were independent of the concentration of NP and addition of BSA. Spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) of respective protons of NP were independent of the concentration, but depended on the concentration of BSA added. The binding position of NP to BSA was considered to involve the hydrophobic aromatic moiety of NP from the ratio of spin-spin relaxation rates (1/T2) of NP bound to BSA and free NP. © 1995 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bspy.350010204
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    Paper (German National Licenses)
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