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  • 1
    Electronic Resource
    Electronic Resource
    Fatty Acids from Degenerating Myelin Lipids Are Conserved and Reutilized for Myelin Synthesis During Regeneration in Peripheral Nerve (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Following nerve crush, cholesterol from degenerating myelin is conserved and reutilized for new myelin synthesis during nerve regeneration. The possibility that other myelin lipids are salvaged and reutilized has not been investigated previously. We examined the fate of myelin phospholipids and their fatty acyl moieties following nerve crush by electron microscopic autoradiography of myelin lipids prelabeled with [3H]oleate or [2-3H]-glycerol. Both precursors were incorporated predominantly (〉90%) into phospholipids; 〉85% of the [3H]oleate was incorporated as oleate, with the remainder in longer-chain fatty acids. Before nerve crush, both labels were restricted to myelin sheaths. Following nerve crush and subsequent regeneration, over half the label from [3H]oleate, but little from [2-3H]glycerol, remained in nerve. The oleate label was present as fatty acyl moieties in phospholipids and was localized to newly formed myelin sheaths. Among the extracellular soluble lipids within the degenerating nerve, the bulk of the labeled phospholipids floated at the same density as lipoprotein particles. These data indicate that myelin phospholipids are completely hydrolyzed during nerve degeneration, that at least half the resultant free fatty acids are salvaged and reutilized for new myelin synthesis, and that these salvaged fatty acids are transported by a lipoprotein-mediated mechanism similar to that functioning in cholesterol reutilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65041752.x
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  • 2
    Electronic Resource
    Electronic Resource
    Nerve Regeneration and Cholesterol Reutilization Occur in the Absence of Apolipoproteins E and A-I in Mice (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Apolipoproteins have been implicated in the salvage and reutilization of myelin cholesterol during Wallerian degeneration and the subsequent nerve regeneration. Current evidence suggests that myelin cholesterol complexes with apolipoproteins E and A-I to form lipoproteins that are taken up via low-density lipoprotein receptors on myelinating Schwann cells. We recently reported, however, that apolipoprotein E is not required for nerve regeneration or reutilization of myelin cholesterol. We have now investigated nerve regeneration and the reutilization of cholesterol in mutant mice deficient in both apolipoproteins E and A-I. Morphologic examination of nerves 4 and 12 weeks after crush injury revealed that regeneration proceeded at a normal rate in the absence of these apolipoproteins. Autoradiography of regenerating nerves indicated that prelabeled myelin lipid was reutilized in the regenerating myelin. 3-Hydroxy-3-methylglutaryl-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, was down-regulated in the regenerating nerves, indicative of cholesterol uptake via lipoproteins. Prelabeled myelin cholesterol was present in lipoprotein fractions isolated from crushed nerves of mutant mice. These data suggest that there is considerable redundancy in the process of cholesterol reutilization within nerve, and that apolipoproteins other than apolipoproteins E and A-I may be involved in the recycling of myelin cholesterol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64010408.x
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  • 3
    Electronic Resource
    Electronic Resource
    1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 2596-2605 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00014a012
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  • 4
    Electronic Resource
    Electronic Resource
    Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 9-12 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00001a003
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  • 5
    Electronic Resource
    Electronic Resource
    1.alpha.,25-Dihydroxyvitamin D3 Analogs Featuring Aromatic and Heteroaromatic Rings: Design, Synthesis, and Preliminary Biological Testing (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 4529-4537 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00022a019
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  • 6
    Electronic Resource
    Electronic Resource
    Adhesion assessment of silicon carbide, carbon, and carbon nitride ultrathin overcoats by nanoscratch techniques : The 41st annual conference on magnetism and magnetic materials (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 81 (1997), S. 5396-5398 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This paper presents experimental results for adhesion assessment of 20 nm ultrathin SiC, amorphous carbon and carbon nitride films deposited on silicon (111) substrates by sputtering. In the experiment, the ultrathin overcoats were scratched by a face-forward Berkovich diamond indenter with a continuous depth sensing nanoscratch system. Experimental results indicate that the nanoscratch system has very good sensitivity for detecting ultrathin overcoat cracking, delamination, and brittle fracture caused by scratching. A well-defined critical load for each film was determined by the nanoscratch techniques. The highest critical load (800 μN) is found for the CN film and the lowest (500 μN) is for SiC. Scanning electron microscopy (SEM) investigations to the surface damage of the samples reveal that the SiC overcoat was damaged more severely than other films due to its brittle fracture. The adhesion properties of the three films tested in this work are best in carbon nitride, followed by amorphous carbon and then silicon carbide. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.364551
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  • 7
    Electronic Resource
    Electronic Resource
    Correlation of magnetic Barkhausen noise with core loss in oriented 3% Si–Fe steel laminates (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 3156-3167 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The angular dependence of surface magnetic Barkhausen noise (MBN) with flux densities up to 1.7 T on eight different samples of oriented 3% Si–Fe steel laminate was investigated. On two of the samples encircle MBN measurements were performed. MBN energy values were obtained by integrating the square of the MBN voltage signal with respect to time. The angular variation of the MBN energy signal was modeled by considering anisotropic internal fields that moderate 180° domain wall motion and the local eddy current field interactions between spatially correlated Barkhausen events. The eddy current field interactions arising between 180° domain walls that lie along the sample's primary easy axis direction were represented by a parameter, α′. α′ had a cos θ angular dependence where θ is the angle of the applied sweep field with respect to the sample rolling direction. The angular averaged MBN energy signal, 〈Energy〉, was evaluated and compared with core losses measured using the standard Epstein technique at 1.5 T. Surface MBN measurements on samples with higher 〈Energy〉 demonstrated lower core loss. This was associated with a larger proportion of microscopic eddy currents generated parallel to the sample plane which were, therefore, uncoupled from macroscopic eddy currents generated by the bulk magnetization of the sample. Larger surface 〈Energy〉 signals were identified with a finer domain wall structure. For samples with a nonzero α′, the core loss was observed to decrease with increasing α′ magnitude. This was interpreted as a result of a reduction of microscopic eddy currents arising from an increase in interactions between simultaneously moving 180° domain walls. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361258
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  • 8
    Electronic Resource
    Electronic Resource
    Flux penetration of an aluminum liner during working fluid compression (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 78 (1995), S. 2260-2264 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Phillips Laboratory working fluid experiment is a research effort to study the compression of a hot hydrogen gas using an electromagnetically imploded solid liner. In our experiments, the solid liner is driven by a 5 MJ discharge which Joule heats the aluminum, melting and eventually vaporizing it. This numerical study explores the vaporization and flux penetration of a solid aluminum liner during its implosion. In particular, it considers the effect that flux which has penetrated the liner has on the hot hydrogen working fluid. A study of the dynamics of the solid liner was performed with one-dimensional radiation magnetohydrodynamic simulations, which included a careful treatment of the electrical resistivity near the phase transitions. An analytic snowplow model is developed in order to estimate the minimum working fluid density required to ignore flux penetration through the liner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.360142
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  • 9
    Electronic Resource
    Electronic Resource
    Investigation of the stress-dependent magnetic easy axis in steel using magnetic Barkhausen noise (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 4242-4252 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Angular-dependent magnetic Barkhausen noise (MBN) measurements were performed on a pipeline steel sample for various values of applied uniaxial stress at three angles with respect to the sample's zero stress magnetic easy axis direction. It was observed that the response of the MBN signal to stress was dependent upon the direction of the stress with respect to the zero stress easy axis. The stress response of the MBN signal was greatest for (i) tensile stresses oriented perpendicular to the zero stress easy axis direction and (ii) compressive stresses applied parallel to the easy axis direction. The modification of the MBN signal under an applied stress was attributed primarily to a change in the 180° domain wall population in the material investigated. Results were described by a model that considered regions of locally correlated domain behavior, termed "interaction regions,'' that were typically the size of grains within the steel material. A basic result of the model was the stress required to modify the number of 180° domain walls within an interaction region. Theoretical calculations of these threshold stresses for a typical grain size were found to be in agreement with the range of applied stresses that was observed to modify the angular-dependent MBN signal obtained from the sample. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361878
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  • 10
    Electronic Resource
    Electronic Resource
    Near ultraviolet photolysis of HFCO: The H+FCO channel (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 6198-6201 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The technique of H (Rydberg) atom photofragment translational spectroscopy has been used to study the process HFCO(S1)→H+FCO(X˜), near its appearance threshold, at excitation wavelengths ca. 247 nm. Analyses of the resulting total kinetic energy release spectra lead to an accurate determination of the C–H bond strength: D0(H–FCO)=34950±20 cm−1. The resulting FCO fragments are observed to be formed with little internal energy, distributed mainly in the form of a-axis rotation. Fragmentation is shown to involve S1–T1 intersystem crossing, followed by rapid passage along the minimum energy path to the eventual H+FCO products. This minimum energy path involves passage over (or H atom tunnelling through) a saddle point, the height of which is ≥4740 cm−1 above the dissociation asymptote. The observed propensity for a-axis rotation in the FCO product reflects changes in the parent geometry as it evolves along the C–H dissociation coordinate on the T1 surface; past the saddle point, the barrier energy is released largely in the form of product recoil.© 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473243
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