ISSN:
1435-1803
Schlagwort(e):
Myocyte
;
human
;
relaxation
;
β-adrenoceptors
;
cyclic AMP
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Myocytes from failing human ventricle contract and relax more slowly than those from non-failing. This has been suggested to result from the lowering of basal cyclic AMP level in failing myocardium, and the consequent withdrawal of a tonic lusitropic effect. We present data to support this hupothesis by demonstrating that the acceleration of contraction and relaxation by β-adrenoceptor stimulation is greater in myocytes from failing than nonfailing heart. This is despite the desensitisation of the inotropic effect of isorenaline in the same failing cells. Following β-adrenoceptor stimulation, speeds of contraction and relaxation are normalised in myocytes from failing heart, with final values not significantly different from non-failing.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00795363
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