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  • 1990-1994  (5)
  • 1985-1989  (1)
  • 1980-1984  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 669 (1992), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 498 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 629-632 
    ISSN: 1432-1335
    Keywords: Methotrexate ; diarrhea ; Small intestine ; Prostaglandin ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intraperitoneal administration of methotrexate in a single dose of 40 mg/kg induces fluid accumulation in the small intestine of rats, significantly increasing jejunal PGE2 formation and simultaneously the amounts of PGE2 in the intestinal contents in vivo. Concomitantly, jejunal PGD2 and 6-keto-PGF1α generation and the amounts of these prostaglandins in the intestinal contents were significantly lowered. However, PGD2 and 6-keto-PGFα jejunal release, and the amounts of these prostaglandins found in the intestinal contents, were already low after a subletal dose (4 mg/kg) of methotrexate, whereas the jejunal release as well as the amounts in the intestinal contents of PGE2 were not altered. Fluid accumulation, the amounts of prostaglandins in the intestinal contents and jejunal release of prostaglandins are siginificantly inhibited by indomethacin. The increased jejunal synthesis of PGE2, with its enteropooling effect, may play a significant role in methotrexate-induced diarrhea in rats.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 228 (1980), S. 351-363 
    ISSN: 1433-8491
    Keywords: Suicide ; Clinical psychiatry ; Hospitalism ; Open-door ; Rehabilitation ; Suicid ; Klinikpsychiatrie ; Hospitalismus ; Open-door ; Rehabilitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Suicidzahlen psychiatrischer Klinikpatienten steigen in mehreren Ländern steiler an als die Aufnahmezahlen der Kliniken und als die Suicidraten der Regionen. Dies trifft auch für die eigene Klinik zu. Der klinische Suicidanstieg läßt sich aber nicht durch eine zunehmende „Vorverlegung“ von Suiciden erklären, die früher infolge der geschlosseneren Behandlung erst nach der Hospitalisierung geschehen wären. Dies zeigt die Überprüfung aller Suicidfälle der engeren Region in den letzten 20 Jahren hinsichtlich ihrer allfälligen vorangegangenen Hospitalisierungen. Auch die Zusammensetzung sowohl der Suicidierten wie aller Ausgetretenen nach Geschlecht, Alter, Hospitalisierungszahl, Hospitalisierungsdauer und Diagnose ist praktisch gleich geblieben und erklärt den klinischen Suicidanstieg nicht. In beiden Dezennien ereigneten sich die Suicide während der Hospitalisierung nach überdurchschnittlich langen, diejenigen bald (innert 3 Monaten) nach Klinikentlassung nach überdurchschnittlich kurzen letzten Hospitalisierungszeiten. Suchtkranke sind gegenüber ihrem Anteil an allen Ausgetretenen unter diesen katamnestisch Suicidierten ebenso stark übervertreten wie Depressive; Schizophrene dagegen sind untervertreten. Dem klinischen Suicidanstieg gehen liberalisierende Tendenzen der Klinikführung voran (vermehrte Ausgänge, Urlaube, Auswärtsarbeit, Abteilungsöffnungen). Die erhebliche Vermehrung der Arztstellen vermochte den Suicidanstieg nicht zu verhindern. Eine gewisse Rolle scheint der zunehmende, Hospitalismus-präventiv intendierte Rehabilitationsdruck zu spielen. Die Möglichkeiten der Suicidprävention werden diskutiert.
    Notes: Summary In several countries the suicide rate for psychiatric inpatients has increased more than that for admissions and suicides in the general population. This was also the case in our clinic. This hypothesis was tested: today, because of more liberal management, suicides are committed during hospitalization that in an earlier and more restrictive age would have taken place after discharge. All suicides taking place 1960–1979 in the clinic's main catchment area were examined for previous hospitalization. The hypothesis was not supported. Over twenty years neither the suicide cases nor all discharged patients changed significantly in distribution of age, sex, number of previous admissions, duration of hospitalization, or diagnosis. Therefore, none of these variables explain the increase. In both decades, on the other hand, patients that committed suicide during their stay at the clinic had been hospitalized longer; those that committed suicide within three months after discharge had been hospitalized for a shorter time than the sum of discharged patients. Among the suicides that occurred after discharge, the percentage of depressives and addicts was higher and the percentage of schizophrenic patients was smaller than among all discharged patients. A Change in patient management (more time off, more working outside, more open wards) has preceded the increase in suicides; medical staff, however, has doubled over the decades considered here. Rising pressure for resocialization to avoid hospitalism may heighten suicidal behavior. Preventive measures are discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-2568
    Keywords: stomach ; human gastric mucosa ; muscarinic receptor subtype ; acid secretion ; glandular M3 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 ±6 fmollmg protein and the tritiated ligand N-methylscopolamine had an affinity of (KD)0.39±0.08 nM (n=11). The M1 receptor selective antagonist pirenzepine and the M2 receptor selective ligand AF-DX 116 had low affinities of 148±32 nM (n=13) and 4043±1011 nM (n=3) KD,respectively. The glandular M3 antagonists hexahydrosiladifenidol and silahexocyclium had high affinities of KD 78±23 nM (n=5) and 5.6±1.8 nM (n=3). The agonist carbachol interacted with a single low-affinity site and binding was insensitive to modulation by guanine nucleotides. Antagonist and agonist binding studies thus showed an affinity profile typical of M3 receptors of the glandular type.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The response of Superheated Superconducting Granule (SSG) devices to nuclear recoils has been explored by irradiating SSG detectors with a 70MeV neutron beam. In the past we have tested Al SSG and more recently, measurements have been performed with Sn and Zn detectors. The aim of the experiments was to test the sensitivity of SSG detectors to recoil energies down to a few keV. In this paper, the preliminary results of the neutron irradiation of a SSG detector made of Sn granules 15–20µm in diameter will be discussed. For the first time, recoil energy thresholds of ∼1keV have been measured.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The presented results are part of a feasibility study of a Superheated Superconducting Granule (SSG) device for weakly interacting massive particles (WIMPs) detection. The sensitivity of SSG to nuclear recoils has been explored irradiating SSG detectors with a 70MeV neutron beam proving that energy thresholds of ∼1keV can be reached in 30µm Zn and 17µm Sn granules. The successful irradiation experiments with neutrons encouraged us to plan a prototype SSG dark matter detector. The status of the project will be presented and the expected counting rate for spin-independent WIMP interactions in SSG detectors will be discussed.
    Type of Medium: Electronic Resource
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