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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 65 (1961), S. 417-419 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Polyclonal antibodies were raised to the C-terminal part of the γ-aminobutyric acidA (GABAA) receptor α4-subunit. These anti-peptide α4 (517–523) antibodies specifically identified a protein with apparent molecular mass 67 kDa in rat brain membranes. This protein was enriched by immunoaffinity chromatography of brain membrane extracts on Affigel 10 coupled to the anti-peptide α4 (517–523) antibodies and could then be identified by the anti-α4-antibodies as well as by the GABAA receptor subunit-specific monoclonal antibody bd-28. This appears to indicate that the 67-kDa protein is the α4-subunit of GABAA receptors. Intact GABAA receptors appeared to be retained by the immunoaffinity column because other GABAA receptor subunit proteins like the β2/β3-subunits and the γ2-subunit were detected in the immunoaffinity column eluate. Furthermore, in addition to the 67-kDa protein, a 51-kDa protein could be detected by the antibody bd-28 and the anti-peptide α4 (517–523) antibody in the immunoaffinity column eluate. A protein with similar apparent molecular mass was identified by the α1-subunit-specific anti-peptide α1 (1–9) antibody. In contrast to the α1-subunit, the 51-kDa protein identified by the anti-α4 antibody could not be deglycosylated by N-Glycanase. The identity of the 51-kDa protein identified by the anti-α4-antibodies thus must be further investigated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 225 (1987), S. 346-350 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight “chinchilla bastard” pigmented rabbits were treated intravenously with sonicated phospholipid liposomes (SUV) consisting predominantly of egg yolk phosphatidylcholine (PC). Four rabbits were treated with canthaxanthin incorporated into PC liposomes in a single injection and fractionated over a period of 19 days. The total amount of PC used was a single dose of 260 mg administered as a 50-ml suspension and 13.7 mg/fraction given as a 5-ml suspension. The total amount of canthaxanthin used was a single 40 mg as a 50-ml suspension and 2.1 mg/fraction as 5-ml suspension. Electroretinography showed that canthaxanthin produced a depression of thea-waves and prolongation of the scotopica- andb-wave peak latencies. A single high-dose injection of PC and PC plus canthaxanthin resulted in a transitory reduction in ERG amplitudes. A single injection of PC and canthaxanthin also produced hypernormala-waves within the recovery time. Electron microscopy demonstrated that in contrast to the controls (PC), the canthaxanthin-treated rabbits showed alterations in the RPE/photoreceptor complex, indicating that these layers are the primary site of canthaxanthin effects on the retina.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Parasitological serodiagnosis ; Specificity ; Autoimmune disorders ; Neoplasms ; HIV infection ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from 120 patients with rheumatological disorders, neoplastic disease, infectious mononucleosis, and HIV infection, and from 30 healthy blood donors were tested for nonspecific reactivity in 13 routinely used parasite serological tests. Responses were detected in 3/30 healthy blood donors (10%) vs 25/120 patients (21%). Of 40 responses in these 28 responders most were weakly reactive, and 25 out of 40 responses were only at borderline level. Response rates were highest in patients with mononucleosis presumably due to heterophile antibodies. Only four patients had responses in at least two different serodiagnostic tests for the same parasitic infection. Response patterns indicative of a possible underlying, concurring, or superimposed parasitic infection, thus, were rare. Especially susceptible to nonspecific reactivity seemed to be immunofluorescent antibody tests for filariasis, schistosomiasis, and amebiasis. In conclusion, compared to healthy controls, false-positive serological responses seem to be more frequent in certain disease groups dependent on the test methods used. Second, the use of more than one serodiagnostic test for the same parasitic disease will substantially facilitate the identification of nonspecific reactivity. Third, for better defining the specificity of parasitological serodiagnosis, more studies should include control sera from patients with nonparasitic diseases that frequently show immunological abnormalities.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 773-780 
    ISSN: 1432-1440
    Keywords: Streptococci ; Septicemia ; Acute leukemia ; High dose cytosine arabinoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine adult patients with acute myelogenous leukemia AML who received 40 treatment courses with high dose cytosine arabinoside (HD-A), alone or combined with other cytotoxic drugs, for remission induction (RI) or postremission intensive consolidation (IC) were retrospectively analysed for types and severity of infectious complications. In this paper, we report the unusually high rate of streptococcal septicemia in our patients. Of 13 bacteremic infections in a total of 45 infectious episodes, 10 were caused by streptococci (9 viridans streptococci, 1 group B hemolytic streptococcus). Three of them were lethal. After reviewing all documented cases of streptococcal septicemia in the same study period, four additional cases among adult patients with AML were identified. Three of them have had antileukemic chemotherapy without HD-A, while one have had HD-A as a conditioning regimen for bone marrow transplantation. Only three cases were documented to occur in adult patients with AML. Patients treated with HD-A for RI or IC had a significantly lower risk of streptococcal septicemia during previous chemotherapy-associated febrile neutropenic episodes (1/55 vs 10/45;P=0.01). Neither prophylactic regimens including trimethoprim-sulfamethoxazole nor those without it were effective in preventing streptococcal septicemia. Further studies are needed to confirm these data before the value of additional or alternative prophylactic antibiotics is proven necessary.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Computing 37 (1986), S. 219-226 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Wir betrachten Lineare Programme der Form {maxcx|1≤Ax≤b,L≤x≤U} mit nichtnegativen Vektorenl,b,L,U und einer 0–1 MatrixA, die von “Manhattan Skyline” Form ist, d. h. der Träger jeder Zeile vonA ist im Träger jeder folgenden Zeile enthalten. Wir stellen einenO(nm+nlogn)-Algorithmus zur Lösung solcher Probleme vor und untersuchen seinen Anwendungsbereich.
    Notes: Abstract We consider LP's of the form max {cx|l≤Ax≤b, L≤x≤U} where,l,b,L,U are nonnegative andA is a 0–1 matrix which looks like “Manhattan Skyline”, i.e. the support of each row is contained in the support of every subsequent row. AnO(nm+nlogn) algorithm is presented for solving the problem.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Fungal infection ; Bone marrow transplantation ; Amphotericin B inhalations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of invasive fungal infections after bone marrow transplantation (BMT) was analyzed in 303 consecutive marrow graft recipients (allogeneicn=271, autologousn=27, syngeneicn=5). All patients received inhalations with amphotericin B (10 mg twice daily) during neutropenia. The overall incidence of invasive fungal infections within the first 120 days after transplant was 3.6% (11/303; aspergillosis: 6; yeast infection: 5). Four of the 11 cases occurred early, and seven cases were observed after neutrophil recovery and discontinuation of amphotericin B inhalation treatment. Late infection was significantly associated with the development of acute graft-versus-host disease. Four of the 11 infections (early 2/4; late: 2/7) were observed in patients with a history of previous fungal infection. Other patient and treatment characteristics were not helpful in defining potential risk factors. In particular, the incidence of invasive fungal infections did not differ between patients with more or less strict reverse isolation measures. Occasional side effects such as initial mild cough and bad taste were rare, usually disappeared during continued administration, and were in no case the reason for discontinuation of treatment. These data suggest that aerosolized amphotericin B may be a useful, convenient, and efficient prophylactic antifungal regimen in BMT.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of game theory 21 (1992), S. 249-266 
    ISSN: 1432-1270
    Keywords: Cooperative Game ; Shapley Value ; Precedence Constraint ; Marginal Contribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract Cooperative games are considered where only those coalitions of players are feasible that respect a given precedence structure on the set of players. Strengthening the classical symmetry axiom, we obtain three axioms that give rise to a unique Shapley value in this model. The Shapley value is seen to reflect the expected marginal contribution of a player to a feasible random coalition, which allows us to evaluate the Shapley value nondeterministically. We show that every exact algorithm for the Shapley value requires an exponential number of operations already in the classical case and that even restriction to simple games is #P-hard in general. Furthermore, we outline how the multi-choice cooperative games of Hsiao and Raghavan can be treated in our context, which leads to a Shapley value that does not depend on pre-assigned weights. Finally, the relationship between the Shapley value and the permission value of Gilles, Owen and van den Brink is discussed. Both refer to formally similar models of cooperative games but reflect complementary interpretations of the precedence constraints and thus give rise to fundamentally different solution concepts.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1160 Stuhlproben von 160 abwehrgeschwächten Patienten, von 70 Erwachsenen und 180 Kindern mit akuter Diarrhoe und von 60 erwachsenen Kontrollpersonen ohne Diarrhoe und Immundefekt wurden auf Kryptosporidien untersucht. Nur zwei aus der Gruppe symptomatischer Kinder ohne Immundefekt (1,1%) hatten einen positiven Befund (ein Kind mit Kontakt zu einer streunenden Katze und zu Lämmern, das andere ohne bekannte Exposition), dagegen keiner der Erwachsenen mit und ohne Diarrhoe und keiner der abwehrgeschwächten Patienten. Andere, potentiell pathogene Protozoen bei Immundefizienten wurden lediglich bei sieben von 25 HIV-Infizierten nachgewiesen. Wir schließen daraus, daß die Kryptosporidiose im süddeutschen Raum auch bei Kindern eine sehr seltene sporadische Erkrankung ist. Sie sollte jedoch in der Differentialdiagnose der akuten Diarrhoe berücksichtigt werden.
    Notes: Summary 1160 stool specimens, from 160 severely immunocompromised patients, from 70 adults and 180 children with acute diarrhoea and from 60 controls without diarrhoea and without evidence of immunocompromising underlying disorders, were examined for Cryptosporidium excretion. Only two children (1.1%) (one with previous contact to a straying cat and to lambs, the other without known risk) had documented intestinal cryptosporidiosis, whereas none of the symptomatic adults, immunocompromised patients or controls were found to be positive for Cryptosporidium fecal excretion. Other potential protozoal enteric pathogens among immunocompromised patients were only found in seven of 25 patients with HIV infection. We conclude that sporadic intestinal cryptosporidiosis in Southern Germany is a rare disease in humans even of younger age, but should be included in the differential diagnosis of diarrhoea in immunocompetent and immunocompromised patients.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Infection 15 (1987), S. 433-433 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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