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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 41 (1990), S. 401-415 
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic ingestion of bile-acid sequestrants has been shown to decrease the serum cholesterol concentration and coronary events in hypercholesterolaemic patients. To develop improved sequestrants, a rapid, convenient method for testing the bile-acid binding efficacy of sequestrants is needed. Serum bile-acid concentrations could be used to detect bile-acid binding by an administered sequestrant, since the serum bile-acid concentration is determined largely by the rate of intestinal absorption in healthy individuals. To test this, serum bile-acid concentrations were measured at frequent intervals over 24 h in five otherwise healthy hypercholesterolaemic subjects during the ingestion of three standard meals, with or without the addition of 5 g colestipol granules administered 30 min before each meal.Total serum bile-acid concentration was measured with a previously reported bioluminescent enzymic assay, that uses a 3α-hydroxysteroid dehydrogenase, an oxido-reductase, and a bacterial luciferase co-immobilized on to Sepharose beads. Bile acids in 1 ml of serum were isolated by solid-phase extraction chromatography with reversed-phase C18 cartridges.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A dose-response study was performed with three doses of colestipol, using postprandial serum bile acid levels to assess bile acid sequestering activity in 40 volunteers with asymptomatic hyperlipidaemia. Subjects who entered the study had total serum cholesterol concentrations greater than 220 mg/dl and triglyceride concentrations less than 200 mg/dl. They were randomly assigned to one of four parallel treatment groups: (a) placebo b.d., colestipol (as Colestid hydrochloride granules) 2.5 g b.d., (c) colestipol 5 g b.d., and (d) colestipol 7.5 g b.d. Subjects were maintained on a constant repeating solid diet throughout the 6-day study period, and colestipol was ingested 30 min before breakfast and dinner. No drug was administered on Days 1–3; baseline (pre-treatment) serum bile acid concentration profiles were determined on Day 3. The above treatments were given on Days 4–6, and total serum bile acid
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 71 (1993), S. 208-213 
    ISSN: 1432-1440
    Keywords: Allergy ; Whooping cough ; Pertussis toxin ; IgE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate whether pertussis induces the development of allergy, a prospective study was performed in 25 children aged 0.8–12.2 years. The patients underwent allergy diagnostics during pertussis infection and at a follow-up visit 8–14 months later. Diagnostic criteria included the medical history of the patients and their families, a modified skin prick test, measurement of serum IgE and radio-allergosorbent test screening for specific sensitizations. At the time of pertussis, serum IgE concentration in the study group was 62+ 30 kU/ml. At the follow-up visit, there was a significant increase in serum IgE to 137 ± 51 kU/ml, which was also significantly higher than IgE in an age-matched control group. Children at a significantly higher risk for developing IgE increase or new allergic sensitizations were those with a family history of allergy or potentially allergic disease in their personal history. Our results indicate that pertussis may induce IgE production in affected children.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 71 (1993), S. 423-434 
    ISSN: 1432-1440
    Keywords: Cholecystolithiasis ; Supersaturation ; Gallstones ; Cholesterol ; Cholecystitis ; Occlusion of the cystic duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development and growth pattern of solitary and multiple cholesterol gallbladder stones was defined using cholecystography in a prospective study of 48 patients whose initial cholecystograms indicated a stone-free gallbladder and who developed gallstones within the subsequent 5 years. Radiological observations performed over 365 patient-years were complemented by macroscopic examination, radiograms, scanning electron microscopy, and chemical analysis of gallstones from these and other patients obtained at cholecystectomy. Solitary gallstones were found to develop after a precursor phase of over 2 years during which free-floating crystal laminae of cholesterol formed. These laminae subsequently aggregated loosely and underwent external compaction and internal remodeling by movement of cholesterol molecules to form compact spheroids. A single lamina was observed to function as a nucleus for the development of a solitary stone shaped as an ellipsoid. About 10% of solitary stones were found to have a solitary pigment stone in their center. In contrast, multiple cholesterol gallstones formed without a precursor phase. Innumerable, very thin cholesterol crystals appeared which very abruptly aggregated to form spheres of up to 1 mm in diameter. Within 3 months a second aggregation took place in which these spheres coalesced to form mulberry stones. Mulberry stones in turn were transformed either to faceted stones (if many were present in the gallbladder) or to barrel stones (if few were present) over a period of 3 years. It is proposed that temporary occlusion of the cystic duct leads to supersaturation of bile with calcium bilirubinate and/or calcium carbonate which in turn promotes deposition of either or both of these calcium salts on the surface of single or multiple gallstones. For multiple gallstones, this process or the deposition of additional cholesterol crystals seals the gallstone surface and is followed by metamorphosis of the stone center.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 408-416 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ascutney Mountain complex of eastern Vermont, USA, is a composite epizonal pluton of genetically related gabbro to granite intrusives. Nd isotopic data are reported for mafic rocks, granites, and nearby country rock. The parental mafic magma producing the complex 122 m.y. ago had 87Sr/86Sr=0.7039, 143Nd/144Nd=0.512678 (ɛ Nd=+3.8) and δ 18O=6.1‰, indicating a mantle source with time-integrated lithophile element depletion. Uniform initial radiogenic isotope ratios for granites, which are undistinguishable from those for the most primitive gabbro, suggest that the granite magma evolved from the mafic magma without crustal contamination and that the increase in δ 18O, to about 7.8‰, is the result of fractional crystallization. Mafic rocks show a large range in initial 143Nd/144Nd ratio, from about 0.51267 to 0.51236 (ɛ Nd= +3.7 to −2.5), which is correlated with elevated 87Sr/86Sr ratios and δ 18O. These data substantiate the production of mafic lithologies by fractional crystallization of the parental magma accompanied by assimilation of up to about 50% crust. The local country rocks include gneiss and schist and assimilation involved representatives of both rock types. The isotopic and chemical relationships preclude derivation from a single batch of magma undergoing contamination and indicate that a large magma body at depth evolved largely by fractionation with batches of melt issued from this chamber being variably contaminated at higher levels or at the level of emplacement. The Precambrian gneisses of the Chester dome and overlying lower Paleozoic schists have essentially identical Nd isotope systematics which suggest a crustal formation age of about 1.6. b.y. The parental sediments for the schists were apparently derived from a protolith similar to the gneissic basement without appreciable Sm/Nd fractionation.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 97 (1987), S. 31-42 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ivrea zone represents a tilted cross section through deep continental crust. Sm-Nd isotopic data for peridotites from Baldissero and Balmuccia and for a suite of gabbros from the mafic formation adjacent to the Balmuccia peridotite provide evidence for an event of partial melting 607±19 Ma ago in an extended mantle source with ɛ 607 Nd =+0.4±0.3. The peridotites are interpreted as the corresponding melt residue, the lower part of the mafic formation as the complementary melts which underwent further differentiation immediately after extraction. The Finero body represents a complex with layers of phlogopite peridotite, hornblende peridotite, and amphibole-rich gabbro. The isotopic signatures fall into two groups: (1) highly radiogenic Nd and low-radiogenic Sr characterize the phlogopite-free, amphibole-rich rocks, whereas (2) low-radiogenic Nd and highly radiogenic Sr is found in ultramafics affected by “phlogopite metasomatism”. Phlogopite metasomatism in the Ivrea zone is dated by a Rb-Sr whole rock isochron yielding 293±13 Ma. It was fed by K-rich fluids which were probably derived from metasediments. The high initial ɛ 293 Nd value of about +7.5 for phlogopite-free samples indicates a high time-integrated Sm/Nd ratio in the Finero protolith 293 Ma ago. Sm-Nd analyses of metapelites from the paragneiss series yield Proterozoic “crustal residence ages” of 1.2 to 1.8 Ga. Internal Sm-Nd isochrons for three garnetiferous rocks show that closure of garnet at temperatures around 600° C or even lower occurred about 250 Ma ago.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Apparent crustal residence ages indicated by Nd model age data for metamorphic rocks, sediments and granitoids of the Hercynian Fold Belt of Europe vary from 1.3 Ga to 3.0 Ga, but are mainly in the range 1.4–1.7 Ga. 2 Ga basement inliers have been documented previously in northern Spain and islands off northwestern France but, in addition to these, old (∼2–3 Ga) model ages are found along the southern margin of the fold belt. These do not identify old inliers but are interpreted to represent Archeanearly Proterozoic crustal components recycled from a southern source. The Nd data, when considered together with the surface geology and recent single-grain zircon ion microprobe data, argue against a binary mixing of Archean components with new Palaeozoic crustal additions to generate the main 1.4–1.7 Ga model age population. Hercynian Europe comprise mainly recycled Proterozoic components although significant new Palaeozoic additions as well as Archean contributions are indicated. Nd and Sr isotopic data together with previous chemical and petrographic observations allow the recognition of a northern belt of continent margin I-type granitoids grading southwards to inner continent S-type plutons in the eastern half of the fold belt. This felsic plutonic association is used to infer a Hercynian plate configuration involving the attachment of the fold belt to a southern parent cratonic block that the model age data suggest may be of early Proterozoic-Archean age.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 175-178 (Nov. 1994), p. 1009-1014 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Crust formation ages inferred on the basis of Nd model age, U-Pb zircon and Pb-Pb data for granulites from central Sri Lanka, and the late Archean Lewisian (Scotland) and Nuk (south-western Greenland) high-grade gneisses are comparable, and in the range 2.2–3.0 Ga and 2.8–3.0 Ga respectively. The time interval between crust formation and high-grade metamorphism (with its attendant depletions of incompatible and heat-producing elements) is in the order of ∼ 2 Ga for the ∼ 0.6 Ga Highland granulites of Sri Lanka, but are less than ∼ 0.1–0.2 Ga for the Lewisian and Nuk gneisses. Severe depletions of U and Th produced the distinctive unradiogenic present-day Pb ratios of the Lewisian and Nuk gneisses. The Sri Lanka granulites, in contrast, preserve a record of an extended residence in a high U/Pb, high Th/Pb environment and display radiogenic »upper crustal« — like present-day isotope ratios. Relative to primitive mantle compositions, the Pb isotopes identify the Lewisian and Nuk terrains as crustal reservoirs depleted in Th and U (relative to Pb), whereas the Highland granulites are enriched. The global Pb isotope mass balance requires the existence of low U/Pb, low Th/Pb and high Th/U reservoir(s) for successful solutions, and the lower crust is a likely candidate for this reservoir. High-grade terrains like Sri Lanka show depletions of measured U and Th abundances relative to Pb, but do not show Pb isotope signatures of »model bulk lower crust«. Archean high-grade gneisses display the appropriate combination of retarded Th/Pb and U/Pb although their absolute compositions are much less radiogenic than those of »model bulk lower crust« predicted from simple mass balance calculations.
    Abstract: Résumé Les âges modèles de formation de la croûte, estimés à partir des méthodes Nd, U-Pb (zircon) et Pb-Pb, pour les granulites du Sri Lanka central d'une part et les gneiss de degré élevé lewisiens (Archéen sup.) d'Ecosse et de Nuk (sud-ouest du Groenland) d'autre part, sont comparables et se situent respectivement dans les intervalles de 2,2–3,0 Ga et 2,8–3,0 Ga. L'intervalle de temps qui sépare la formation de la croûte et le pic du métamorphisme (accompagné de pertes d'éléments incompatibles et producteurs de chaleur) est de l'ordre de ± 2 Ga pour les granulites du Sri Lanka, âgées de ± 0,6 Ga, mais n'excède pas 0,1 à 0,2 Ga pour le Lewisien et les gneiss de Nuk. Des pertes sévères en U et en Th sont responsables des rapports Pb actuels peu radiogéniques dans le Lewisien et les gneiss de Nuk. Par contre, les granulites du Sri Lanka se sont maintenues dans des conditions de rapports U/Pb et Th/Pb élevés et fournissent des rapports isotopiques analogues à ceux de la croûte supérieure actuelle. Par rapport aux compositions mantéliques primitives, les isotopes du Pb identifient le Lewisien et les formations de Nuk comme des réservoirs crustaux appauvris en Th et en U (par rapport au Pb), tandis que les granulites du Sri Lanka ont été enrichies. Le bilan de masse des isotopes du Pb à l'échelle globale requiert l'existence d'un ou de plusieurs réservoirs à faible U/Pb, faible Th/Pb et haut Th/U; la croûte inférieure pourrait constituer ce réservoir. Des formations très métamorphiques comme celles du Sri Lanka présentent un appauvrissement des teneurs en U et en Th par rapport au Pb, mais ne montrent pas les signatures isotopiques du Pb correspondant à un modèle de croûte inférieure globale. Les gneiss archéens de degré élevé possèdent la combinaison adéquate des rapports Th/Pb et U/Pb déprimés, bien que leurs compositions absolues soient moins radiogéniques que celle de la »croûte inférieure type« prévue par les bilans de masse.
    Notes: Zusammenfassung Nd-Modellalter, U-Pb-Zirkondaten sowie Pb-Pb-Alter weisen auf vergleichbare Krustenbildungsalter von 2.2–3.0 Ga für den zentralen Granulitgürtel Sri Lankas bzw. 2.8–3.0 Ga für die spätarchaischen Granulitgebiete der Lewisian-(Schottland) und Nuk-Komplexe (südwestliches Grönland) hin. Die extrem lange Zeitspanne von ca. 2 Ga zwischen Krustenbildung und hochgradiger Metamorphose und die daraus resultierende Verarmung an hochinkompatiblen Elementen unterscheidet jedoch die ca. 0.6 Ga alten Granulite der Highland- und Südwest-Gruppe Sri Lankas von den Lewisian- und Nuk-Gneisen. Hier erfolgte die Granulitmetamorphose verhältnismäßig bald nach der Krustenbildung (≤ 0.1–0.2 Ga), und die frühe signifikante Verarmung an U und Th ist verantwortlich für die heutige, wenig radiogene Pb-Isotopie in diesen Gesteinen. Im Gegensatz dazu zeigen Konzentrationsmessungen an den Granuliten Sri Lankas zwar eine Verarmung von U und Th relativ zu Pb, was aber aus der hochradiogenen Pb-Isotopie nicht ersichtlich ist. Der Grund hierfür ist, daß dieser Krustenkomplex eine sehr lange Zeit zur kontinentalen Oberkruste gehörte, mit entsprechend hohen U/Pb- und Th/Pb-Verhältnissen und dem daraus entstandenen Zuwachs an radiogenem Blei. Die terrestrische Massenbilanz des Bleis erfordert, daß die zeitintegrierten erhöhten U/Pb-, Th/Pb- und erniedrigten Th/U-Werte sowohl der Oberkruste als auch fast aller Mantel-derivate durch ein Reservoir, wie z.B. die Unter-kruste, mit langfristig erniedrigtem U/Pb und Th/ Pb und erhöhtem Th/U kompensiert werden muß. Krustenkomplexe wie Sri Lanka, die erst in jüngster Zeit in die Unterkruste versenkt wurden, kommen dafür nicht in Frage. Archaische Granulitgebiete, jedoch, zeigen das entsprechende Th/Pb und U/Pb, wenn auch ihre absolute Zusammensetzung deutlich weniger radiogen ist als es die Modellunterkruste verlangt.
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