ISSN:
1476-5535
Keywords:
Antifungal
;
Sch 40873
;
Candida albicans
;
Mycelial
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Sch 40873, a novel antifungal compound isolated from the fermentation broth of anActinomadura spp. was discovered in an assay designed to detect compounds with preferential activity against the invasive mycelial form ofCandida albicans. The geometric mean MIC of Sch 40873 against sevenCandida spp. in Sabouraud dextrose broth (yeast phase) was ≥58 μg/ml and in Eagles minimum essential medium (mycelial phase) was 〈0.03 μg/ml. Sch 40873 demonstrated slight in vivo topical activity in a hamster vaginal model.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01575593
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