Electronic Resource
Springer
Child's nervous system
7 (1991), S. 327-331
ISSN:
1433-0350
Keywords:
CO2 reactivity
;
Autoregulation
;
Fetal brain
;
Intraventricular hemorrhage
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Intraventricular hemorrhage (IVH) in preterm infants is well known to be associated with the high morbidity and mortality of this group. Previous studies have suggested altered cerebral blood flow (CBF) as an important pathologic factor. We measured the CBF in nearterm rabbit fetuses using the hydrogen clearance technique. The local CBF of the rabbit fetuses was significantly low compared with that of the maternal rabbits. The response of CBF to changes in PaCO2 was observed in rabbit fetuses. The CO2 reactivity index of the fetal rabbit was lower than that of the maternal rabbit. This low CO2 reactivity might reflect the immaturity of the fetal brain and its low CBF. We were unable to monitor the fetal blood pressure, but the fetal CBF remained stable when the maternal blood pressure was altered. It is well known that IVH in preterm infants originates from the subependymal germinal matrix and that this has many fragile vessels. Our observation suggests that even a small increase of CBF during hypercapnia might have a large effect towards producing hemorrhage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00304831
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