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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 5 (1993), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two new oligonucleotide anti-sense probes and their corresponding sense probes specific for mouse GAP-43 mRNA were synthesized and end-labelled with digoxygenin. They were used to localize GAP-43 mRNA in the spinal cords of normal mice and in mice 3 and 7 days following unilateral sciatic nerve cut. GAP-43 mRNA was found to be expressed at low levels in motor and other neurons of the normal spinal cords. As expected from other studies, up-regulation occurred in the cell bodies of axotomized motor neurons but, in addition, up-regulation was also observed in the cell bodies of intact motor neurons contralateral to the lesion. Densitometer measurements showed that the up-regulation of GAP-43 mRNA was less in the intact, contralateral motor neuron cell bodies than in the axotomized motor neuron cell bodies and furthermore was transient, being higher at 3 days than at 7 days following axotomy. Both anti-sense probes gave the same result, although differences in cellular localization were observed, and the two sense probes were negative. Probe binding was abolished by pretreatment of the sections with ribonuclease and hybridization was carried out under different conditions of stringency in order to ascertain whether the contralateral expression of GAP-43 mRNA was a true reflection of its distribution in vivo. There is conflicting evidence on the presence or absence of contralateral effects following unilateral peripheral nerve injury in the literature, and it is suggested that these differences can be accounted for by the methodology and type of probe used.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 22 (1992), S. 893-897 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 58 (1989), S. 341-347 
    ISSN: 1439-6327
    Keywords: Saliva ; Aldosterone ; Glucocorticoid ; High altitude
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Saliva was collected from six healthy young men at hourly intervals at sea level and after 1–2, 8–9 and 15–16 days at 4450 m on Mount Kenya for measurement of aldosterone (SA) and glucocorticoid (SGC, cortisol + cortisone) concentrations. Blood samples were collected simultaneously with some of the saliva samples and analysis of these showed that plasma and saliva concentrations of aldosterone and glucocorticoids were highly correlated (r=0.91 and 0.75 respectively;p〈0.01 for both hormones). Mean SA for the group was reduced to approximately 50% of the sea-level value (p〈0.05) by the time the first saliva samples were collected at altitude, and remained at this depressed level throughout the 2-week period on Mount Kenya, although there was considerable inter-subject variation. SGC concentration also tended to be lower on Mount Kenya than at sea level. Though SA was lower throughout the day at altitude compared to sea level, the principal difference in the temporal pattern of SA was the reduction or complete absence of the marked rise in SA that normally occurs in the first few hours after rising. SA and SGC responses to exercise, which consisted of stepping on and off an 0.4-m high stool 60 times/min for 25 min, were assessed at sea level and after various periods at 4450 m. At altitude the SGC response was significantly enhanced, but the SA response was blunted. The exercise-induced increase in SA correlated with the mean diurnal SA of the previous or next day (r=0.74;p〈0.01). Our data indicate that at altitude there is a decrease in aldosterone response to both renin-angiotensin and ACTH stimulation, which suggests that hypobaric hypoxia has a direct, inhibitory effect upon the zona glomerulosa. They also demonstrate the usefulness of collecting saliva for the measurement of adrenocortical steroid concentrations during expeditions of this type, thus permitting the non-invasive monitoring of adrenocortical activity during real life situations.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-1536
    Keywords: Oxybutylene/oxyethylene triblockcopolymer ; micellisation ; gelation properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A triblock-copoly(oxybutylene/oxyethylene), denoted E58 B17 E58 (80 wt-% E), was prepared by sequential anionic copolymerisation and its micellar and gelation properties in aqueous solution were determined. The oxybutylene/oxyethylene copolymer had the advantage over comparable oxypropylene/oxyethylene copolymers of greater uniformity of composition and chain length. The methods generally used were surface tension, light scattering intensity, photon correlation spectroscopy, together with observation of gelation. Measurements were made at 30°, 40° and 55° C over a full concentration range from dilute solution into the gel (〉200 g dm−3) and at specified concentrations, including the gel, over the temperature range from 10° to 70° C. The lower and upper temperature boundaries of the gel region were identified, and the occurrence of syneresis was noted. The properties investigated and discussed include critical micelle and gel concentrations, micellar weights and sizes, and structures and mobilities in the gel.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Cross-sections for diffractive particle production and pseudorapidity distributions of the decay products of diffractive states are presented. The data were obtained with the UA 5 streamer chamber detector at the CERNpp Collider operated in a new pulsed mode yieldingpp interactions at c.m. energies of 900 and 200 GeV. Data recorded with a special trigger designed to select a sample of events enriched in single-diffractive interactions clearly favour ap t -limited fragmentation of diffractive states. The cross-section for single-diffractive particle production ϊ was found to be 7.8±0.5±1.1 mb at 900 GeV and 4.8±0.5±0.8 mb at 200 GeV (first error statistical, second systematic). From the pseudorapidity distribution of diffractive states we deduce the average number of charged particles to be 6.5±1.0 at 900 GeV and 4.1±1.1 at 200 GeV. Furthermore we report on our estimates for the cross-section of double-diffractive particle production at both Collider energies.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The transverse momentum distributions ofW andZ bosons produced in $$\bar pp$$ collisions at $$\sqrt s = 630 GeV$$ are examined. Comparisons are made with QCD predictions, and good agreement is found. The fraction ofW bosons produced withp T 〉25 GeV is found to be 3.8±0.6(stat) −1.3 +0.9 (syst)%.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Data on antiproton-proton cross sections at the c.m. energies 200 and 900 GeV are presented. The data were obtained at the CERN antiproton-proton Collider operated in a new pulsed mode in which the same beams were accelerated and decelerated between beam energies of 450 and 100 GeV. The properties of the machine determine the ratio of the luminosities at the two energies to about 1% and thus an accurate measurement of the ratioR of the inelastic cross sections could be made. We findR (=σ 900/σ 200)=1.20±0.01±0.02, where the first error is statistical and the second systematic. Interpolating existing data to estimateσ ine1(200 GeV) this measurement ofR leads toσ ine1(900 GeV)=50.3+0.4+1.0 mb. Using an extrapolated value ofσ e1/σ tot we estimate the total cross section at 900 GeV to be 65.3±0.7±1.5 mb. Both the inelastic and total cross sections are compatible with a ln2 s dependence. Comparisons are made with different fits to the total cross section energy dependence.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract New data are presented on charged particle pseudorapidity distributions for inelastic events produced at c.m. energies $$\sqrt s $$ =200 and 900 GeV. The data were obtained at the CERN antiproton-proton Collider operated in a new pulsed mode. The rise of the central density ρ(0) at energies up to $$\sqrt s $$ =900 GeV has been studied. A new form of central region scaling is found involving the densityρ n (0) for charged multiplicityn, namely that the scaled central densityρ n (0)/ρ(0) expressed as a function ofz=n/〈n〉 is independent ofs. Scaling in the fragmentation region holds to 10–20%, and the small amount of scalebreaking observed here could be accommodated within the framework suggested by Wdowcyk and Wolfendale to account for both accelerator and cosmic ray data.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We analyze the energy density distribution in harronic final states as a function of their total transverse energy measured in the segmented central calorimeter of the UA2 detector. The energy dependence of collective shape variables is investigated. The data, collected at the CERN $$\bar p$$ p Collider at $$\sqrt s = 630$$ GeV, exhibit strong variations in all these variables over the transverse energy range between 15 and 210 GeV, corresponding to substantial modifications in the structure of multihadronic final states. The evolution of the energy density distribution and of the collective shape variables shows a clear transition between two extreme dynamical regimes, respectively dominated byp T -limited phase space and by collimated two-jet configurations. A study of the relative populations of two-and three-jet systems reveals two different sources of configurations having three distinct lobes in the pattern of the energy-flow. A first component, steeply falling with energy, receives substantial contributions from soft parton collisions at lower transverse energies. Above 60 GeV a new hard component emerges, characterized by an approximately constant rate with respect to the dominant two-jet structures.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 26 (1991), S. 3057-3061 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Thick films of superconducting oxides, YBa2Cu3O7-δ, were successfully made by conventional screen-printing technology on Al2O3, MgO, and ZrO2 substrates. Interdiffusion between the superconductive film and substrate was investigated using analytical electron microscopy. The results indicate that MgO and ZrO2 are superior to Al2O3 for substrate materials.
    Type of Medium: Electronic Resource
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