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  • 1990-1994  (3)
  • 1985-1989  (3)
  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, others factors, possibly the receptor population or their responsiveness, are also important contributors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Religious studies 30 (1994), S. 305-310 
    ISSN: 0034-4125
    Source: Cambridge Journals Digital Archives
    Topics: Theology and Religious Studies
    Notes: In his paper ‘Has the Ontological Argument Been Refuted?’ (Religious Studies, 29 (1993), 97–110) William F. Vallicella argues that my attempt to show that the Ontological Argument begs the question is unsuccessful.1 I believe he is wrong about this, but before endeavouring to vindicate my position I must first make clear what precisely is the point at issue between us. The Ontological Argument is not a single argument, but a family of arguments. Newly devised formulations of the argument are frequently put forward by philosophers in an effort to avoid difficulties that have been pointed out in previous versions. As a consequence there is no possibility of a conclusive proof that every form of the argument embodies the same fallacy. Nevertheless, one can, I believe, prove that all the standard versions of the argument embody a certain fallacy and that, given the nature of the argument, it is therefore unlikely that the argument can be formulated in such a way as to avoid this difficulty. What I tried to show in my paper is that the six best-known versions of the argument (the non-model versions of Anselm, Descartes and Leibniz and the modal versions of Malcolm, Hartshorne and Plantinga) all beg the question and that they do so at the same point in the argument, namely when it is asserted that it is possible that an absolutely perfect being exists. It is difficult to see how an ontological argument could be formulated without including this claim as one of its premises, since the distinguishing badge of the argument is the inference from the possibility of an absolutely perfect being to its actuality. It must be unlikely then, if my criticism of these six versions is correct, that there is any way of formulating the argument that avoids this fallacy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Philosophy 63 (1988), S. 529-533 
    ISSN: 0031-8191
    Source: Cambridge Journals Digital Archives
    Topics: Philosophy
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Religious studies 28 (1992), S. 61-64 
    ISSN: 0034-4125
    Source: Cambridge Journals Digital Archives
    Topics: Theology and Religious Studies
    Notes: Theism, according to David O'Connor, has in recent centuries been on trial for its life, the charge being that the existence of so much evil in the world is incompatible with belief in a benevolent creator. But this trial, he claims is incapable of producing a reasoned verdict.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1463
    Keywords: Melatonin ; Seasonal Affective Disorder ; human ; phototherapy ; winter depression ; circadian rhythm ; phase response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is well-established that human nocturnal melatonin secretion is suppressed by presentation of artificial light 〉2,000 lux, a level that is also therapeutically effective in alleviating winter depression symptoms of Seasonal Affective Disorder [SAD]. Furthermore, early-morning bright light induces phase advances of the melatonin cycle in SAD patients (Lewy et al., 1987 a). The functional significance of melatonin in SAD remains unclear. With plasma melatonin sampled at 20-min intervals in a series of overnight studies, we found marked phase delays of the cycle, relative to that previously reported for normals, in 4/5 depressed SAD patients. 2,500 lux light exposure at 6–8a.m. resulted in exponentially declining melatonin levels that approached low daytime baselines within two hours (t1/2 = 45.52 min). All five patients showed clinical remissions as well as phase advances of the melatonin cycle of 0.75 to 3.27 hours (mean, 1.94± 0.84hours) after one week of daily exposure from 6–8a.m. and p.m. These results suggest that the combination of early morning and early evening light exposures induces circadian phase adjustments similar to those of morning light alone, by impacting a photosensitive interval when, in SAD, melatonin secretion overshoots its normal nocturnal phase.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 338 (1989), S. 599-600 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ONE of the most fascinating displays of energy release is the phenomenon of luminescence. In the broadest sense, luminescence is the conversion of energy into light. The energy required for the emission of light is generated by the oxida-tion of a specific substrate. Biological luminescence, or ...
    Type of Medium: Electronic Resource
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