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Succinic Semialdehyde as a Substrate for the Formation of γ-Aminobutyric Acid (1985)

Bemmelen, F. J. ; Schouten, M. J. ; Fekkes, D. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 45 (1985), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: The conversion of succinic semialdehyde into γ-aminobutyric acid (GABA) by GABA-transaminase was measured in rat brain homogenate in the presence of different concentrations of the cosubstrate glutamate. The calculated kinetic parameters of succinic semialdehyde for GABA-transaminase were a limiting Km value of 168 μM and a limiting Vmax value of 38 μmol g−1 h−1. Combination with previously obtained data for the conversion of GABA into succinic semialdehyde revealed a kEq value of 0.04, indicating that equilibrium of GABAtransaminase is biased toward the formation of GABA. The increased formation of GABA in the presence of succinic semialdehyde was not due to an increased conversion of glutamate into GABA by glutamic acid decarboxylase. Therefore these results indicate that succinic semialdehyde can act as a precursor for GABA synthesis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb07214.x

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Impact of climatic change on bog ecosystems, with special reference to sub-oceanic raised bogs (1992)

Schouten, M. G. C. ; Streefkerk, J. G. ; Molen, P. C.

Springer

Wetlands ecology and management 2 (1992), S. 55-61

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ISSN: 1572-9834

Keywords: Climatic change ; bog ecosystems ; N.W.-Europe

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract The relation between climatic conditions and type of peatland ecosystem in the different climate zones in Europe is discussed. Special attention is given to the hydrology of raised bogs in the sub-oceanic region. Possible effects of climatic change on such raised bog systems are discussed in terms of changes in water discharge, ground-water table, rate of peat accumulation, and flora and vegetation. It is concluded that future changes, as suggested by the more widely accepted scenarios for climatic change, will seriously disrupt the ecological functioning of these peatland ecosystems, and it is doubtful whether at least the most southerly examples of sub-oceanic raised bogs will at all survive. Finally, suggestions are given for future research on the impact of climatic change on peatland ecosystems.